Nasopharyngeal bacterial interactions in children

Antimicrobial treatments and vaccines can alter bacterial interactions in the nasopharynx, thereby altering disease processes. To better understand these interactions, we examined colonization rates of 3 respiratory bacterial pathogens among 320 children when healthy and at onset of acute otitis med...

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Bibliographic Details
Published in:	Emerging infectious diseases Vol. 18; no. 11; pp. 1738 - 1745
Main Authors:	Xu, Qingfu, Almudervar, Anthony, Casey, Janet R, Pichichero, Michael E
Format:	Journal Article
Language:	English
Published:	United States U.S. National Center for Infectious Diseases 01-11-2012 Centers for Disease Control and Prevention
Subjects:	Bacterial Infections - epidemiology Bacterial Infections - microbiology bacterial interaction Bacterial pneumonia Behavior Child, Preschool Children CME Development and progression Female Haemophilus influenzae Host-Pathogen Interactions Humans Infant Male Moraxella catarrhalis Nasopharynx - microbiology New York - epidemiology Otitis Media - epidemiology Otitis Media - microbiology Pneumonia polymicrobial colonization Prevalence Risk Factors Staphylococcus aureus Staphylococcus aureus infections Streptococcus pneumoniae Vaccines New York
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Summary:	Antimicrobial treatments and vaccines can alter bacterial interactions in the nasopharynx, thereby altering disease processes. To better understand these interactions, we examined colonization rates of 3 respiratory bacterial pathogens among 320 children when healthy and at onset of acute otitis media (AOM). Bacterial interactions were analyzed with a repeated measures logistic regression model. Among healthy children, Streptococcus pneumoniae and Moraxella catarrhalis were synergistically (positively) associated. Colonization with S. pneumoniae when healthy, but not at onset of AOM, was competitively (negatively) associated with Staphylococcus aureus. Among children with AOM, competitive associations were found between Haemophilus influenzae and S. pneumoniae and between H. influenzae and M. catarrhalis; rates of colonization with H. influenzae were higher. Bacterial interactions result in differing pathogen prevalence during periods of health and at onset of AOM. H. influenzae might become a more common cause of AOM among children who receive pneumococcal conjugate vaccine.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1811.111904