Search Results - "Almouzni, G"

7: Chromatin dynamics and cell cycle: From histone variants to heterochromatin by Almouzni, G

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Targeting chromatin defects in selected solid tumors based on oncogene addiction, synthetic lethality and epigenetic antagonism by Morel, D., Almouzni, G., Soria, J.-C., Postel-Vinay, S.

“…Although the role of epigenetic abnormalities has been studied for several years in cancer genesis and development, epigenetic-targeting drugs have…”
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Functional Characterization of Histone Chaperones Using SNAP-Tag-Based Imaging to Assess De Novo Histone Deposition by Clément, C, Vassias, I, Ray-Gallet, D, Almouzni, G

“…Histone chaperones-key actors in the dynamic organization of chromatin-interact with the various histone variants to ensure their transfer in and out of…”
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Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases by Almouzni, Geneviève, Taddei, Angela, Maison, Christèle, Roche, Danièle

“…Histone modifications might act to mark and maintain functional chromatin domains during both interphase and mitosis. Here we show that pericentric…”
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CAF-1 and the inheritance of chromatin states: at the crossroads of DNA replication and repair by Ridgway, P, Almouzni, G

“…Chromatin is no longer considered to be a static structural framework for packaging DNA within the nucleus but is instead believed to be an interactive…”
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Heterochromatin at mouse pericentromeres: a model for de novo heterochromatin formation and duplication during replication by Maison, C, Quivy, J-P, Probst, A V, Almouzni, G

“…How a nuclear domain is formed at specific chromatin loci and maintained throughout multiple cellular divisions is a central question in the field of nuclear…”
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The ins and outs of nucleosome assembly by Mello, Jill A, Almouzni, Geneviève

“…De novo nucleosome assembly coupled to DNA replication and repair in vitro involves the histone chaperone chromatin assembly factor 1 (CAF-1). Recent studies…”
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Constraints on transcriptional activator function contribute to transcriptional quiescence during early Xenopus embryogenesis by Almouzni, G., Wolffe, A.P.

“…We have examined the cause of transcriptional quiescence prior to the mid‐blastula transition (MBT) in Xenopus laevis. We have found distinct requirements for…”
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Histone Acetylation Influences both Gene Expression and Development of Xenopus laevis by Almouzni, Geneviève, Khochbin, Saadi, Dimitrov, Stefan, Wolffe, Alan P.

“…We examine the potential role of histone hyperacetylation in gene activation daring Xenopus development using Trichostatin A, (TSA), a specific inhibitor of…”
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Chromatin assembly and organization by Ridgway, P, Almouzni, G

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Two distinct nucleosome assembly pathways: dependent or independent of DNA synthesis promoted by histone H3.1 and H3.3 complexes by Nakatani, Y, Ray-Gallet, D, Quivy, J-P, Tagami, H, Almouzni, G

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Chromatin assembly factor-1, a marker of clinical value to distinguish quiescent from proliferating cells by POLO, Sophie E, THEOCHARIS, Stamatios E, KLIJANIENKO, Jerzy, SAVIGNONI, Alexia, ASSELAIN, Bernard, VIELH, Philippe, ALMOUZNI, Geneviève

“…Histone synthesis and chromatin assembly are mainly associated with DNA replication and are thus intimately involved in cell cycle regulation. The expression…”
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Chromatin and DNA replication by MacAlpine, David M, Almouzni, Geneviève

“…The size of a eukaryotic genome presents a unique challenge to the cell: package and organize the DNA to fit within the confines of the nucleus while at the…”
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Incomplete RNA polymerase II phosphorylation in Xenopus laevis early embryos by Palancade, B, Bellier, S, Almouzni, G, Bensaude, O

“…Phosphorylation of RNA polymerase II largest subunit on its C-terminal domain (CTD) heptapeptide repeats has been shown to play a key role in the regulation of…”
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Marking histone H3 variants: How, when and why? by Loyola, Alejandra, Almouzni, Geneviève

“…DNA in eukaryotic cells is compacted into chromatin, a regular repeated structure in which the nucleosome represents the basic unit. The nucleosome not only…”
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Assembly of spaced chromatin involvement of ATP and DNA topoisomerase activity by Almouzni, G., Méchali, M.

“…Undiluted extracts from eggs or oocytes of Xenopus laevis support the assembly of chromatin with physiologically spaced nucleosomes. Micrococcal nuclease and…”
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Chromatin Challenges during DNA Replication and Repair by Groth, Anja, Rocha, Walter, Verreault, Alain, Almouzni, Geneviève

“…Inheritance and maintenance of the DNA sequence and its organization into chromatin are central for eukaryotic life. To orchestrate DNA-replication and -repair…”
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HP1 and the dynamics of heterochromatin maintenance by Maison, Christèle, Almouzni, Geneviève

“…Heterochromatin maintenance is crucial for the clonal inheritance of cell identity, to ensure the proper segregation of chromosomes and the regulation of gene…”
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LifeTime and improving European healthcare through cell-based interceptive medicine by Rajewsky, Nikolaus, Almouzni, Geneviève, Gorski, Stanislaw A., Aerts, Stein, Amit, Ido, Bertero, Michela G., Bock, Christoph, Bredenoord, Annelien L., Cavalli, Giacomo, Chiocca, Susanna, Clevers, Hans, De Strooper, Bart, Eggert, Angelika, Ellenberg, Jan, Fernández, Xosé M., Figlerowicz, Marek, Gasser, Susan M., Hubner, Norbert, Kjems, Jørgen, Knoblich, Jürgen A., Krabbe, Grietje, Lichter, Peter, Linnarsson, Sten, Marine, Jean-Christophe, Marioni, John C., Marti-Renom, Marc A., Netea, Mihai G., Nickel, Dörthe, Nollmann, Marcelo, Novak, Halina R., Parkinson, Helen, Piccolo, Stefano, Pinheiro, Inês, Pombo, Ana, Popp, Christian, Reik, Wolf, Roman-Roman, Sergio, Rosenstiel, Philip, Schultze, Joachim L., Stegle, Oliver, Tanay, Amos, Testa, Giuseppe, Thanos, Dimitris, Theis, Fabian J., Torres-Padilla, Maria-Elena, Valencia, Alfonso, Vallot, Céline, van Oudenaarden, Alexander, Vidal, Marie, Voet, Thierry

“…Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to…”
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Competition between transcription complex assembly and chromatin assembly on replicating DNA by Almouzni, G., Méchali, M., Wolffe, A.P.

“…We have used a Xenopus egg extract to show that a competition exists between the assembly of transcription complexes and nucleosomes on replicating 5S DNA…”
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