Search Results - "Almeida, O. F. X"

Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation by CROCHEMORE, C, LU, J, WU, Y, LIPOSITS, Z, SOUSA, N, HOLSBOER, F, ALMEIDA, O. F. X

“…An important question arising from previous observations in vivo is whether glucocorticoids can directly influence neuronal survival in the hippocampus. To…”
Get full text

The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling by Bessa, J M, Ferreira, D, Melo, I, Marques, F, Cerqueira, J J, Palha, J A, Almeida, O F X, Sousa, N

“…The mechanisms underlying the initiation/onset of, and the recovery from, depression are still largely unknown; views that neurogenesis in the hippocampus may…”
Get full text

The amyloidogenic potential and behavioral correlates of stress by Catania, C., Sotiropoulos, I., Silva, R., Onofri, C., Breen, K. C., Sousa, Nuno, Almeida, O. F. X.

“…Observations of elevated basal cortisol levels in Alzheimer's disease (AD) patients prompted the hypothesis that stress and glucocorticoids (GC) may contribute…”
Get full text

A hitchhiker’s guide to behavioral analysis in laboratory rodents by Sousa, Nuno, Almeida, O. F. X., Wotjak, C. T.

“…Genes and environment are both essential and interdependent determinants of behavioral responses. Behavioral genetics focuses on the role of genes on behavior…”
Get full text

Acute and chronic stress differentially regulate cyclin-dependent kinase 5 in mouse brain: implications to glucocorticoid actions and major depression by Papadopoulou, A, Siamatras, T, Delgado-Morales, R, Amin, N D, Shukla, V, Zheng, Y-L, Pant, H C, Almeida, O F X, Kino, T

“…Stress activates the hypothalamic–pituitary–adrenal axis, which in turn increases circulating glucocorticoid concentrations and stimulates the glucocorticoid…”
Get full text

Dissociation of the morphological correlates of stress-induced anxiety and fear by Pêgo, J. M., Morgado, P., Pinto, L. G., Cerqueira, J. J., Almeida, O. F. X., Sousa, N.

“…Chronic stress is a powerful modulator of emotional behaviour. Previous studies have shown that distinct neuronal pathways modulate different emotional…”
Get full text

Mechanisms of initiation and reversal of drug-seeking behavior induced by prenatal exposure to glucocorticoids by Rodrigues, A J, Leão, P, Pêgo, J M, Cardona, D, Carvalho, M M, Oliveira, M, Costa, B M, Carvalho, A F, Morgado, P, Araújo, D, Palha, J A, Almeida, O F X, Sousa, N

“…Stress and exposure to glucocorticoids (GC) during early life render individuals vulnerable to brain disorders by inducing structural and chemical alterations…”
Get full text

Citalopram-mediated anxiolysis and differing neurobiological responses in both sexes of a genetic model of depression by Kokras, N, Sotiropoulos, I, Pitychoutis, P.M, Almeida, O.F.X, Papadopoulou-Daifoti, Z

“…Abstract Disorders such as depression and anxiety exhibit strong sex differences in their prevalence and incidence, with women also differing from men in their…”
Get full text

Neurodevelopment milestone abnormalities in rats exposed to stress in early life by Mesquita, A.R, Pêgo, J.M, Summavielle, T, Maciel, P, Almeida, O.F.X, Sousa, N

“…Abstract Manipulation of the corticosteroid milieu by interfering with the mother–newborn relationship has received much attention because of its potential…”
Get full text

Corticosteroid status influences the volume of the rat cingulate cortex – a magnetic resonance imaging study by Cerqueira, J.J., Catania, C., Sotiropoulos, I., Schubert, M., Kalisch, R., Almeida, O.F.X., Auer, D.P., Sousa, N.

“…Imbalances in the corticosteroid milieu result in reductions in hippocampal volume in humans and experimental rodents. The functional correlates of these…”
Get full text

Hippocampal neurogenesis induced by antidepressant drugs: an epiphenomenon in their mood-improving actions by Bessa, J. M., Ferreira, D., Melo, I., Marques, F., Cerqueira, João José, Palha, Joana Almeida, Almeida, O. F. X., Sousa, Nuno

“…Image of a niche of newly formed neurons in the subgranular zone of the hippocampal dentate gyrus, obtained by confocal microscopy. Red: Ki-67-positive cells;…”
Get full text

Subtle shifts in the ratio between pro‐ and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate by Almeida, O. F. X., Condé, G. L., Crochemore, C., Demeneix, B. A., Fischer, D., Hassan, A. H. S., Meyer, M., Holsboer, F., Michaelidis, T. M.

“…Glucocorticoid receptor (GR) activation induces apoptosis of granule cells in the hippocampus. In contrast, neuroprotection is seen after mineralocor‐ticoid…”
Get full text

Sex Hormone Depletion Augments Glucocorticoid Induction of Tau Hyperphosphorylation in Male Rat Brain by Monteiro-Fernandes, D., Sousa, N., Almeida, O.F.X., Sotiropoulos, I.

“…•Chronic manipulation of glucocorticoids (GC) trigger Tau hyperphosphorylation.•Depletion of male gonadal hormones potentiates GC-induced Tau…”
Get full text

DAXX, FLASH, and FAF-1 modulate mineralocorticoid and glucocorticoid receptor-mediated transcription in hippocampal cells--toward a basis for the opposite actions elicited by two nuclear receptors? by Obradović, D, Tirard, M, Némethy, Zs, Hirsch, O, Gronemeyer, H, Almeida, O F X

“…Mineralocorticoid (MR) and glucocorticoid (GR) receptors are two closely-related members of the steroid nuclear receptor family of transcription factors that…”
Get more information

Ionotropic and metabotropic glutamate receptor mediation of glucocorticoid-induced apoptosis in hippocampal cells and the neuroprotective role of synaptic N-methyl- d-aspartate receptors by Lu, J, Goula, D, Sousa, N, Almeida, O.F.X

“…Glutamate receptors have been proposed to mediate the apoptotic actions of glucocorticoids in hippocampal cells. To further analyze the role of glutamate…”
Get full text

The nucleus reuniens: a key node in the neurocircuitry of stress and depression by Kafetzopoulos, V., Kokras, N., Sotiropoulos, I., Oliveira, João F., Leite-Almeida, Hugo, Vasalou, A., Sardinha, Vanessa Alexandra Morais, Papadopoulou-Daifoti, Z, Almeida, O. F. X., Antoniou, K., Sousa, Nuno, Dalla, C.

“…Uncorrected proof The hippocampus and prefrontal cortex (PFC) are connected in a reciprocal manner: whereas the hippocampus projects directly to the PFC, a…”
Get full text

Age-related qualitative shift in emotional behaviour: Paradoxical findings after re-exposure of rats in the elevated-plus maze by Bessa, J.M., Oliveira, M., Cerqueira, J.J., Almeida, O.F.X., Sousa, N.

“…Several variables, including age, are known to influence anxiety. Previous exposure to the elevated-plus maze (EPM) is known to modify emotional behaviour as…”
Get full text

Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses by Roselli, F, Tirard, M, Lu, J, Hutzler, P, Lamberti, P, Livrea, P, Morabito, M, Almeida, O F X

“…Amyloid-beta (Abeta) has been implicated in memory loss and disruption of synaptic plasticity observed in early-stage Alzheimer's disease. Recently, it has…”
Get full text

Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes by Kokras, N., Sotiropoulos, I., Besinis, D., Tzouveka, E.L., Almeida, O.F.X., Sousa, N., Dalla, C.

“…Environmental enrichment (EE), comprising positive physical (exercise) and cognitive stimuli, influences neuronal structure and usually improves brain…”
Get full text

Sustained remission from depressive-like behavior depends on hippocampal neurogenesis by Mateus-Pinheiro, A, Pinto, L, Bessa, J M, Morais, M, Alves, N D, Monteiro, S, Patrício, P, Almeida, O F X, Sousa, N

“…Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a…”
Get full text