Constituintes químicos e atividade Leishmanicida de Gustavia elliptica (Lecythidaceae)

Constituintes químicos e atividade Leishmanicida de Gustavia elliptica (Lecythidaceae)

The phytochemical investigation of the stem bark and leaves of G. elliptica provided a mixture of the norisoprenoids blumenol B and 6-epiblumenol B along with the triterpenes friedelin, as the major constituent, friedelanol, ursa-9(11),12-dien-3-ol, a-amyrin, β-amyrin, morentenol, epifriedelanol, as...

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Bibliographic Details
Published in:Química Nova Vol. 34; no. 7; pp. 1182 - 1187
Main Authors: Almeida, Maria de Fátima Oliveira, Melo, Ana Cláudia Rodrigues de, Pinheiro, Maria Lúcia Belém, Silva, Jefferson Rocha de Andrade, Souza, Afonso Duarte Leão de, Barison, Andersson, Campos, Francinete Ramos, Amaral, Ana Cláudia Fernandes, Machado, Gerzia Maria de Carvalho, Leon, Leonor Laura Pinto
Format: Journal Article
Language:English
Published: Sociedade Brasileira de Química 2011
Subjects:
6-epiblumenol B
blumenol B
Gustavia elliptica
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Summary:The phytochemical investigation of the stem bark and leaves of G. elliptica provided a mixture of the norisoprenoids blumenol B and 6-epiblumenol B along with the triterpenes friedelin, as the major constituent, friedelanol, ursa-9(11),12-dien-3-ol, a-amyrin, β-amyrin, morentenol, epifriedelanol, as well as the sesquiterpenes trans-caryophyllene, α-humulene, ethyl hydnocarpate and other fatty acid esters. The identification of the compounds was performed on basis of spectrometric methods such as GC-MS, IR, MS and 1D and 2D NMR. Stem bark extracts showed significant leishmanicidal activity against promastigote forms of Leishmania braziliensis, with the best results for the chloroform extract.
ISSN:0100-4042
1678-7064
DOI:10.1590/S0100-40422011000700015