Search Results - "Almeida, Luis E."

Modulation of social deficits and repetitive behaviors in a mouse model of autism: the role of the nicotinic cholinergic system by Wang, Li, Almeida, Luis E. F., Spornick, Nicholas A., Kenyon, Nicholas, Kamimura, Sayuri, Khaibullina, Alfia, Nouraie, Mehdi, Quezado, Zenaide M. N.

“…Rationale Accumulating evidence implicates the nicotinic cholinergic system in autism spectrum disorder (ASD) pathobiology. Neuropathologic studies suggest…”
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Assessment of the Amorphous “Solubility” of a Group of Diverse Drugs Using New Experimental and Theoretical Approaches by Almeida e Sousa, Luis, Reutzel-Edens, Susan M, Stephenson, Gregory A, Taylor, Lynne S

“…The supersaturation potential of poorly water-soluble compounds is of interest in the context of solubility enhancing formulations for enhanced…”
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Increased BDNF expression in fetal brain in the valproic acid model of autism by Almeida, Luis E.F., Roby, Clinton D., Krueger, Bruce K.

“…Human fetal exposure to valproic acid (VPA), a widely-used anti-epileptic and mood-stabilizing drug, leads to an increased incidence of behavioral and…”
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Nicotinic cholinergic system alterations and nitrous oxide exposure in a mouse model: a hypothesis for the pathobiology of autism spectrum disorder by Almeida, Luis E. F., Wang, Li, Khaibullina, Alfia, Quezado, Zenaide M. N.

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Optimization of the modular reinforced bone scaffold for customized alveolar bone defects by Omidi, Meisam, Almeida, Luis E., Tayebi, Lobat

“…[Display omitted] •The optimized modular reinforced scaffold with enhanced mechanical properties is designed.•The optimization significantly improves the…”
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Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease by Tumburu, Laxminath, Ghosh-Choudhary, Shohini, Seifuddin, Fayaz T., Barbu, Emilia A., Yang, Simon, Ahmad, Maliha M., Wilkins, Lauren H.W., Tunc, Ilker, Sivakumar, Ishwarya, Nichols, James S., Dagur, Pradeep K., Yang, Shutong, Almeida, Luis E.F., Quezado, Zenaide M.N., Combs, Christian A., Lindberg, Eric, Bleck, Christopher K.E., Zhu, Jun, Shet, Arun S., Chung, Jay H., Pirooznia, Mehdi, Thein, Swee Lay

“…The pathophysiology of sickle cell disease (SCD) is driven by chronic inflammation fueled by damage associated molecular patterns (DAMPs). We show that…”
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Syk inhibition suppresses NLRP3 inflammasome activation in platelets from sickle cell mice leading to decreased platelet secretion, aggregation, spreading, and in vitro thrombus formation by Vogel, Sebastian, Kamimura, Sayuri, Smith, Meghann L., Almeida, Luis E.F., Cui, Xizhong, Combs, Christian A., Quezado, Zenaide M.N.

“…•Syk inhibition with R406 decreases NLRP3 inflammasome activation in platelets from sickle cell mice.•R406 inhibits platelet activation and in vitro thrombus…”
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Autocrine Activation of Neuronal NMDA Receptors by Aspartate Mediates Dopamine- and cAMP-Induced CREB-Dependent Gene Transcription by Almeida, Luis E. F, Murray, Peter D, Zielke, H. Ronald, Roby, Clinton D, Kingsbury, Tami J, Krueger, Bruce K

“…cAMP can stimulate the transcription of many activity-dependent genes via activation of the transcription factor, cAMP response element-binding protein (CREB)…”
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Mouse models of sickle cell disease: Imperfect and yet very informative by Kamimura, Sayuri, Smith, Meghann, Vogel, Sebastian, Almeida, Luis E F, Thein, Swee Lay, Quezado, Zenaide M N

“…The root cause of sickle cell disease (SCD) has been known for nearly a century, however, few therapies to treat the disease are available. Over several…”
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Calcium flux alterations in erythrocytes from sickle cell mice: The relevance of mean corpuscular volume by Almeida, Luis E F, Smith, Meghann L, Kamimura, Sayuri, Vogel, Sebastian, Quezado, Zenaide M N

“…Red blood cells (RBC) from patients with sickle cell disease (SCD) have elevated calcium levels at baseline, which are further elevated upon deoxygenation…”
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NLRP3 inflammasome and bruton tyrosine kinase inhibition interferes with upregulated platelet aggregation and in vitro thrombus formation in sickle cell mice by Vogel, Sebastian, Kamimura, Sayuri, Arora, Taruna, Smith, Meghann L., Almeida, Luis E.F., Combs, Christian A., Thein, Swee Lay, Quezado, Zenaide M.N.

“…The nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) inflammasome is a critical inflammatory mechanism identified in platelets, which…”
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Nitrite decreases sickle hemoglobin polymerization in vitro independently of methemoglobin formation by Almeida, Luis E.F., Smith, Meghann L., Kamimura, Sayuri, Vogel, Sebastian, de Souza Batista, Celia M., Quezado, Zenaide M.N.

“…The root cause of sickle cell disease (SCD) is the polymerization of sickle hemoglobin (HbS) leading to sickling of red blood cells (RBC). Earlier studies…”
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Defect-engineered Ag/ZnO and Ag2O/ZnO nanomaterials prepared with nanoparticles synthesized by a sustainable sol–gel method and their biological responses by da Silva, Mário R. P., Matos, Robert S., Monteiro, Michael D. S., da Fonseca Filho, Henrique D., Ramos, Glenda Q., Santos, Samuel B., Andrade, Gabriela S., Andrade, George R. S., Almeida, Luis E.

“…ZnO/Ag and ZnO/Ag 2 O nanocomposites were produced using ZnO nanoparticles synthesized via a starch-mediated sol–gel method. XRD and Rietveld refinement…”
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Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model by Quezado, Zenaide M.N., Kamimura, Sayuri, Smith, Meghann, Wang, Xunde, Heaven, Michael R., Jana, Sirsendu, Vogel, Sebastian, Zerfas, Patricia, Combs, Christian A., Almeida, Luis E.F., Li, Quan, Quezado, Martha, Horkayne-Szakaly, Iren, Kosinski, Penelope A., Yu, Shaoxia, Kapadnis, Unnati, Kung, Charles, Dang, Lenny, Wakim, Paul, Eaton, William A., Alayash, Abdu I., Thein, Swee Lay

“…Polymerization of deoxygenated sickle hemoglobin (HbS) leads to erythrocyte sickling. Enhancing activity of the erythrocyte glycolytic pathway has…”
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Locomotor mal-performance and gait adaptability deficits in sickle cell mice are associated with vascular and white matter abnormalities and oxidative stress in cerebellum by Almeida, Luis E.F., Wang, Li, Kamimura, Sayuri, Zerfas, Patricia M., Smith, Meghann L., Neto, Osorio L. Abath, Vale, Ticiana, Quezado, Martha M., Horkayne-Szakaly, Iren, Wakim, Paul, Quezado, Zenaide M.N.

“…•Sickle cell disease (SCD) patients can have abnormal cerebellum on imaging studies.•SCD mice have evidence of cerebellar behavior deficits as described in SCD…”
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Supramolecular polyelectrolyte complexes based on cyclodextrin-grafted chitosan and carrageenan for controlled drug release by Evangelista, Thamasia F.S., Andrade, George R.S., Nascimento, Keyte N.S., dos Santos, Samuel B., de Fátima Costa Santos, Maria, Da Ros Montes D'Oca, Caroline, dos S. Estevam, Charles, Gimenez, Iara F., Almeida, Luís E.

“…[Display omitted] •Supramolecular polyelectrolyte complex between βCD-CS and CRG were prepared.•Silver sulfadiazine was incorporated to the polyelectrolyte…”
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Exploiting the Physicochemical and Antimicrobial Properties of PHB/PEG and PHB/PEG/ALG-e Blends Loaded with Ag Nanoparticles by Silva, Mário R. P. da, Matos, Robert S, Monteiro, Michael D. S, Santos, Samuel B, Filho, Henrique D. F, Andrade, George R. S, Salerno, Marco, Almeida, Luís E

“…Poly(3-hydroxybutyrate) (PHB)-based films containing Poly(ethylene glycol) (PEG), esterified sodium alginate (ALG-e) and polymeric additives loaded with Ag…”
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Sickle cell disease subjects and mouse models have elevated nitrite and cGMP levels in blood compartments by Almeida, Luis E.F., Kamimura, Sayuri, de Souza Batista, Celia M., Spornick, Nicholas, Nettleton, Margaret Y., Walek, Elizabeth, Smith, Meghann L., Finkel, Julia C., Darbari, Deepika S., Wakim, Paul, Quezado, Zenaide M.N.

“…The hypothesis of decreased nitric oxide (NO) bioavailability in sickle cell disease (SCD) proposes that multiple factors leading to decreased NO production…”
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Altered nocifensive behavior in animal models of autism spectrum disorder: The role of the nicotinic cholinergic system by Wang, Li, Almeida, Luis E.F., Nettleton, Margaret, Khaibullina, Alfia, Albani, Sarah, Kamimura, Sayuri, Nouraie, Mehdi, Quezado, Zenaide M.N.

“…Caretakers and clinicians alike have long recognized that individuals with autism spectrum disorder (ASD) can have altered sensory processing, which can…”
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Sickle cell disease mice have cerebral oxidative stress and vascular and white matter abnormalities by Khaibullina, Alfia, Almeida, Luis E.F., Kamimura, Sayuri, Zerfas, Patricia M., Smith, Meghann L., Vogel, Sebastian, Wakim, Paul, Vasconcelos, Olavo M., Quezado, Martha M., Horkayne-Szakaly, Iren, Quezado, Zenaide M.N.

“…Strokes are feared complications of sickle cell disease (SCD) and yield significant neurologic and neurocognitive deficits. However, even without detectable…”
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