Search Results - "Almeida, Claudia G."

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses by Almeida, Claudia G., Tampellini, Davide, Takahashi, Reisuke H., Greengard, Paul, Lin, Michael T., Snyder, Eric M., Gouras, Gunnar K.

“…Synaptic dysfunction is increasingly viewed as an early manifestation of Alzheimer's disease (AD), but the cellular mechanism by which β-amyloid (Aβ) may…”
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Internalized Antibodies to the Aβ Domain of APP Reduce Neuronal Aβ and Protect against Synaptic Alterations by Tampellini, Davide, Magrané, Jordi, Takahashi, Reisuke H., Li, Feng, Lin, Michael T., Almeida, Cláudia G., Gouras, Gunnar K.

“…Immunotherapy against β-amyloid peptide (Aβ) is a leading therapeutic direction for Alzheimer disease (AD). Experimental studies in transgenic mouse models of…”
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Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice by Li, Feng, Calingasan, Noel Y., Yu, Fangmin, Mauck, William M., Toidze, Marine, Almeida, Claudia G., Takahashi, Reisuke H., Carlson, George A., Flint Beal, M., Lin, Michael T., Gouras, Gunnar K.

“…A growing body of evidence suggests a relationship between oxidative stress and β‐amyloid (Aβ) peptide accumulation, a hallmark in the pathogenesis of…”
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Women's sense of coherence and its association with early weaning by Cortelo, Fernando M., Marba, Sérgio T.M., Cortellazzi, Karine L., Ambrosano, Glaucia M.B., Guerra, Luciane M., Almeida, Ana Cláudia G., Tomar, Scott L., Silva, Margarete Ribeiro da, Possobon, Rosana F.

“…To investigate whether there is an association between sense of coherence levels and early weaning. This study had a quantitative nature and a cross-sectional…”
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Myosin 1b promotes the formation of post-Golgi carriers by regulating actin assembly and membrane remodelling at the trans -Golgi network by Coudrier, Evelyne, Almeida, Claudia G, Yamada, Ayako, Tenza, Danièle, Louvard, Daniel, Raposo, Graça

“…The function of organelles is intimately associated with rapid changes in membrane shape. By exerting force on membranes, the cytoskeleton and its associated…”
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Alzheimer's disease risk factor CD2AP functions at synapses via spinal F‐actin by Mirfakhar, Farzaneh S., Almeida, Claudia G.

“…Background In late‐onset Alzheimer's disease (LOAD), the causal mechanisms of synaptic dysfunction underlying memory deficits that lead to dementia remain…”
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BIN1 LOAD mutants increase intracellular Aβ by interfering with BACE1 recycling by Barata, Mariana Afonso, Perdigão, Catarina, Almeida, Claudia G.

“…Background Amyloid β (Aβ) accumulation and endosome dysfunction play an early role in Alzheimer’s disease (AD), an untreatable synaptic disorder. APP cleavage…”
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Lysosomal subcellular distribution in neurons: Are there synaptic lysosomes? by Cunha, César Augusto Vogado, Burrinha, Tatiana, Almeida, Claudia G.

“…Background Despite Alzheimer's disease's first description 114 years ago1, the mechanisms driving the most common late‐onset forms' molecular etiology and…”
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Regulation of NMDA receptor trafficking by amyloid-β by Snyder, Eric M, Nong, Yi, Almeida, Claudia G, Paul, Surojit, Moran, Timothy, Choi, Eun Young, Nairn, Angus C, Salter, Michael W, Lombroso, Paul J, Gouras, Gunnar K, Greengard, Paul

“…Amyloid-beta peptide is elevated in the brains of patients with Alzheimer disease and is believed to be causative in the disease process. Amyloid-beta reduces…”
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beta-Amyloid Accumulation Impairs Multivesicular Body Sorting by Inhibiting the Ubiquitin-Proteasome System by Almeida, Claudia G, Takahashi, Reisuke H, Gouras, Gunnar K

“…Increasing evidence links intraneuronal beta-amyloid (Abeta42) accumulation with the pathogenesis of Alzheimer's disease (AD). In Abeta precursor protein (APP)…”
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Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease by Gouras, Gunnar K., Almeida, Claudia G., Takahashi, Reisuke H.

“…Plaques are a defining neuropathological hallmark of Alzheimer's disease (AD) and the major constituent of plaques, the β-amyloid peptide (Aβ), is considered…”
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Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain by Takahashi, Reisuke H, Almeida, Claudia G, Kearney, Patrick F, Yu, Fangmin, Lin, Michael T, Milner, Teresa A, Gouras, Gunnar K

“…Multiple lines of evidence implicate beta-amyloid (Abeta) in the pathogenesis of Alzheimer's disease (AD), but the mechanisms whereby Abeta is involved remain…”
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The Arctic Alzheimer mutation favors intracellular amyloid‐β production by making amyloid precursor protein less available to α‐secretase by Sahlin, Charlotte, Lord, Anna, Magnusson, Kristina, Englund, Hillevi, Almeida, Claudia G., Greengard, Paul, Nyberg, Fred, Gouras, Gunnar K., Lannfelt, Lars, Nilsson, Lars N.G.

“…Mutations within the amyloid‐β (Aβ) domain of the amyloid precursor protein (APP) typically generate hemorrhagic strokes and vascular amyloid angiopathy. In…”
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Amyloid-β oligomers are inefficiently measured by enzyme-linked immunosorbent assay by Stenh, Charlotte, Englund, Hillevi, Lord, Anna, Johansson, Ann-Sofi, Almeida, Claudia G., Gellerfors, Pär, Greengard, Paul, Gouras, Gunnar K., Lannfelt, Lars, Nilsson, Lars N. G.

“…Amyloid‐β (Aβ) peptide levels are widely measured by enzyme‐linked immunosorbent assay (ELISA) in Alzheimer's disease research. Here, we show that…”
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The late‐onset Alzheimer's disease genetic risk factor CD2AP impacts synapses via actin dynamics: Basic science and pathogenesis: Genetics and omics of AD by Mirfakhar, Farzaneh S., Almeida, Claudia G.

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The late‐onset Alzheimer's disease genetic risk factor CD2AP impacts synapses via actin dynamics by Mirfakhar, Farzaneh S., Almeida, Claudia G.

“…Background In late‐onset Alzheimer’s disease (LOAD) the causal mechanisms of synaptic dysfunction that underlie the memory deficits that lead to dementia are…”
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P4-260: Intraneuronal Aβ42 and microtubule-associated protein pathologies begin in synapses by Capetillo-Zarate, Estibaliz, Takahashi, Reisuke H, Almeida, Claudia G, Lin, Michael T, Milner, Teresa A, Gouras, Gunnar K

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Oral biopsies in a Portuguese population: A 20-year clinicopathological study in a university clinic by de Almeida, Cláudia G, Freitas, Filipe, Francisco, Helena, Marques, João A, Caramês, João

“…Performing a biopsy is very important in oral medicine and the anatomopathological examination is fundamental to obtain or to confirm the diagnosis in oral and…”
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Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices by Almeida, Cláudia G., de Mendonça, Alexandre, Cunha, Rodrigo A., Ribeiro, J.Alexandre

“…Reactive oxygen species (ROS) are believed to be involved in the pathogenesis of several neurological disorders. We now tested whether the endogenous…”
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P4-050: Endogenous Abeta42 accumulation in neurons impairs the multivesicular body sorting pathway by Almeida, Claudia G., Gouras, Gunnar K.

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