Search Results - "Almeida, Ángeles"

Pursuing precision in medicine and nutrition: the rise of electrochemical biosensing at the molecular level by Campuzano, Susana, Barderas, Rodrigo, Moreno-Casbas, Maria Teresa, Almeida, Ángeles, Pingarrón, José M.

“…In the era that we seek personalization in material things, it is becoming increasingly clear that the individualized management of medicine and nutrition…”
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Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance by Cabral‐Costa, João Victor, Vicente‐Gutiérrez, Carlos, Agulla, Jesús, Lapresa, Rebeca, Elrod, John W., Almeida, Ángeles, Bolaños, Juan P., Kowaltowski, Alicia J.

“…Intracellular Ca2+ concentrations are strictly controlled by plasma membrane transporters, the endoplasmic reticulum, and mitochondria, in which Ca2+ uptake is…”
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A Missense Variant in TP53 Could Be a Genetic Biomarker Associated with Bone Tissue Alterations by Usategui-Martín, Ricardo, Galindo-Cabello, Nadia, Pastor-Idoate, Salvador, Fernández-Gómez, José María, Del Real, Álvaro, Ferreño, Diego, Lapresa, Rebeca, Martín-Rodriguez, Francisco, Riancho, José A, Almeida, Ángeles, Pérez-Castrillón, José Luis

“…Metabolic bone diseases cover a broad spectrum of disorders that share alterations in bone metabolism that lead to a defective skeleton, which is associated…”
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Neovascularization and functional recovery after intracerebral hemorrhage is conditioned by the Tp53 Arg72Pro single-nucleotide polymorphism by Rodríguez, Cristina, Sobrino, Tomás, Agulla, Jesús, Bobo-Jiménez, Verónica, Ramos-Araque, María E, Duarte, Juan J, Gómez-Sánchez, José C, Bolaños, Juan P, Castillo, José, Almeida, Ángeles

“…Intracerebral hemorrhage (ICH) is a devastating subtype of stroke that lacks effective therapy and reliable prognosis. Neovascularization following ICH is an…”
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AMYLOID-BETA INDUCES P53 STABILIZATION TRIGGERING NEUROINFLAMMATION by González-Guerrero, Sonia, Lapresa, Rebeca, Agulla, Jesus, Parra, Ángeles Almeida

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A novel human Cdh1 mutation impairs anaphase promoting complex/cyclosome activity resulting in microcephaly, psychomotor retardation, and epilepsy by Rodríguez, Cristina, Sánchez‐Morán, Irene, Álvarez, Sara, Tirado, Pilar, Fernández‐Mayoralas, Daniel M., Calleja‐Pérez, Beatriz, Almeida, Ángeles, Fernández‐Jaén, Alberto

“…The Fizzy‐related protein 1 (Fzr1) gene encodes Cdh1 protein, a coactivator of the E3 ubiquitin ligase anaphase‐promoting complex/cyclosome (APC/C)…”
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ROCK2 MODULATES FUNCTIONAL OUTCOME OF HEMORRHAGIC STROKE PATIENTS by Gallego, María Dolores Calabria, González, Cristina Rodríguez, Moreiras, Tomás Sobrino, Parra, Ángeles Almeida

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CDH1 ASP187GLY MUTATION IMPAIRS APC/C ACTIVITY LEADING TO PFKFB3 STABILIZATION by Sancha, Leticia, Sánchez-Morán, Irene, Parra, Ángeles Almeida, Bolanos, Juan P.

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MITOCHONDRIAL REACTIVE OXYGEN SPECIES CONTROLS CORTICAL NEUROGENESIS by Mengual, Regina, González, Cristina Rodríguez, Bobo-Jiménez, Verónica, Delgado-Esteban, María, Bolanos, Juan P., Parra, Ángeles Almeida

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Preclinical validation of human recombinant glutamate-oxaloacetate transaminase for the treatment of acute ischemic stroke by Pérez-Mato, María, Dopico-López, Antonio, Akkoc, Yunus, López-Amoedo, Sonia, Correa-Paz, Clara, Candamo-Lourido, María, Iglesias-Rey, Ramón, López-Arias, Esteban, Bugallo-Casal, Ana, da Silva-Candal, Andrés, Bravo, Susana B., Chantada-Vázquez, María del Pilar, Arias, Susana, Santamaría-Cadavid, María, Estany-Gestal, Ana, Zaghmi, Ahlem, Gauthier, Marc A., Gutiérrez-Fernández, María, Martin, Abraham, Llop, Jordi, Rodríguez, Cristina, Almeida, Ángeles, Migliavacca, Martina, Polo, Ester, Pelaz, Beatriz, Gozuacik, Devrim, El Yamani, Naouale, SenGupta, Tanima, Rundén-Pran, Elise, Vivancos, José, Castellanos, Mar, Díez-Tejedor, Exuperio, Sobrino, Tomás, Rabinkov, Aharon, Mirelman, David, Castillo, José, Campos, Francisco

“…The blood enzyme glutamate-oxaloacetate transaminase (GOT) has been postulated as an effective therapeutic to protect the brain during stroke. To demonstrate…”
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Glycolysis: a bioenergetic or a survival pathway? by Bolaños, Juan P., Almeida, Angeles, Moncada, Salvador

“…Following inhibition of mitochondrial respiration neurons die rapidly, whereas astrocytes utilize glycolytically-generated ATP to increase their mitochondrial…”
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Antioxidant and bioenergetic coupling between neurons and astrocytes by Fernandez-Fernandez, Seila, Almeida, Angeles, Bolaños, Juan P

“…Oxidative and nitrosative stress underlie the pathogenesis of a broad range of human diseases, in particular neurodegenerative disorders. Within the brain,…”
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Glucose metabolism links astroglial mitochondria to cannabinoid effects by Jimenez-Blasco, Daniel, Busquets-Garcia, Arnau, Hebert-Chatelain, Etienne, Serrat, Roman, Vicente-Gutierrez, Carlos, Ioannidou, Christina, Gómez-Sotres, Paula, Lopez-Fabuel, Irene, Resch-Beusher, Monica, Resel, Eva, Arnouil, Dorian, Saraswat, Dave, Varilh, Marjorie, Cannich, Astrid, Julio-Kalajzic, Francisca, Bonilla-Del Río, Itziar, Almeida, Angeles, Puente, Nagore, Achicallende, Svein, Lopez-Rodriguez, Maria-Luz, Jollé, Charlotte, Déglon, Nicole, Pellerin, Luc, Josephine, Charlène, Bonvento, Gilles, Panatier, Aude, Lutz, Beat, Piazza, Pier-Vincenzo, Guzmán, Manuel, Bellocchio, Luigi, Bouzier-Sore, Anne-Karine, Grandes, Pedro, Bolaños, Juan P., Marsicano, Giovanni

“…Astrocytes take up glucose from the bloodstream to provide energy to the brain, thereby allowing neuronal activity and behavioural responses 1 – 5 . By…”
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The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1 by Bolaños, Juan P, Herrero-Mendez, Angel, Almeida, Angeles, Fernández, Emilio, Moncada, Salvador, Maestre, Carolina

“…Neurons are known to have a lower glycolytic rate than astrocytes and when stressed they are unable to upregulate glycolysis because of low Pfkfb3…”
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Brightness and shadows of mitochondrial ROS in the brain by Jimenez-Blasco, Daniel, Almeida, Angeles, Bolaños, Juan P.

“…Mitochondrial reactive oxygen species (mROS) have been generally considered harmful byproducts wanted to clear when elevated to avoid brain damage. However,…”
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E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation by Almeida, Angeles, Bolaños, Juan P, Moncada, Salvador

“…Cell proliferation is known to be accompanied by activation of glycolysis. We have recently discovered that the glycolysis-promoting enzyme…”
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Regulation of glucose metabolism by nitrosative stress in neural cells by Bolaños, Juan P., Cidad, Pilar, Garcı́a-Nogales, Paula, Delgado-Esteban, Marı́a, Fernández, Emilio, Almeida, Ángeles

“…Following brain inflammatory stimuli, astrocytes actively synthesize nitric oxide and peroxynitrite. These nitrogen-derived species trigger a repertoire of…”
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Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice by Burmistrova, Olga, Olias-Arjona, Ana, Lapresa, Rebeca, Jimenez-Blasco, Daniel, Eremeeva, Tatiana, Shishov, Dmitry, Romanov, Sergei, Zakurdaeva, Kristina, Almeida, Angeles, Fedichev, Peter O., Bolaños, Juan P.

“…The glycolytic rate in neurons is low in order to allow glucose to be metabolized through the pentose-phosphate pathway (PPP), which regenerates NADPH to…”
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Glutamate excitoxicity is the key molecular mechanism which is influenced by body temperature during the acute phase of brain stroke by Campos, Francisco, Pérez-Mato, María, Agulla, Jesús, Blanco, Miguel, Barral, David, Almeida, Angeles, Brea, David, Waeber, Christian, Castillo, José, Ramos-Cabrer, Pedro

“…Glutamate excitotoxicity, metabolic rate and inflammatory response have been associated to the deleterious effects of temperature during the acute phase of…”
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Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway by Moncada, Salvador, Almeida, Angeles, Bolaños, Juan P

“…After inhibition of cytochrome c oxidase by nitric oxide, astrocytes maintain energy production by upregulating glycolysis - a response which does not seem to…”
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