Search Results - "Almazan, Guillermina"

IGF-1-stimulated protein synthesis in oligodendrocyte progenitors requires PI3K/mTOR/Akt and MEK/ERK pathways by Bibollet-Bahena, Olivia, Almazan, Guillermina

“…Insulin-like growth factor-1 (IGF-1) interacts with the Type I receptor to activate two main signaling pathways, the mitogen-activated protein kinase kinase…”
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Oligodendrogliopathy in Multiple Sclerosis: Low Glycolytic Metabolic Rate Promotes Oligodendrocyte Survival by Rone, Malena B, Cui, Qiao-Ling, Fang, Jun, Wang, Li-Chun, Zhang, Ji, Khan, Damla, Bedard, Melissa, Almazan, Guillermina, Ludwin, Samuel K, Jones, Russel, Kennedy, Timothy E, Antel, Jack P

“…Multiple sclerosis (MS) lesions feature demyelination with limited remyelination. A distinct injury phenotype of MS lesions features dying back of…”
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Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors by Cui, Qiao Ling, Fang, Jun, Kennedy, Timothy E., Almazan, Guillermina, Antel, Jack P.

“…FTY720 is a sphingosine 1‐phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis…”
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Distinct age and differentiation-state dependent metabolic profiles of oligodendrocytes under optimal and stress conditions by Rao, Vijayaraghava T S, Khan, Damla, Cui, Qiao-Ling, Fuh, Shih-Chieh, Hossain, Shireen, Almazan, Guillermina, Multhaup, Gerhard, Healy, Luke M, Kennedy, Timothy E, Antel, Jack P

“…Within the microenvironment of multiple sclerosis lesions, oligodendrocytes are subject to metabolic stress reflecting effects of focal ischemia and…”
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IGF‐I‐induced oligodendrocyte progenitor proliferation requires PI3K/Akt, MEK/ERK, and Src‐like tyrosine kinases by Cui, Qiao‐Ling, Almazan, Guillermina

“…Insulin‐like growth factor‐I (IGF‐I) is required for the growth of oligodendrocytes, although the underlying mechanisms are not fully understood. Our aim was…”
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p38 Mitogen-Activated Protein Kinase Pathway Regulates Genes during Proliferation and Differentiation in Oligodendrocytes by Haines, Jeffery D, Fulton, Debra L, Richard, Stephane, Almazan, Guillermina

“…We have previously shown that p38 mitogen-activated protein kinase (p38 MAPK) is important for oligodendrocyte (OLG) differentiation and myelination. However,…”
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Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice by Jacomy, Hélène, Fragoso, Gabriela, Almazan, Guillermina, Mushynski, Walter E., Talbot, Pierre J.

“…The notion that an infectious respiratory pathogen can damage the central nervous system (CNS) and lead to neurological disease was tested using a human…”
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The constitutive production of the endocannabinoid 2-arachidonoylglycerol participates in oligodendrocyte differentiation by Gomez, Oscar, Arevalo-Martin, Angel, Garcia-Ovejero, Daniel, Ortega-Gutierrez, Silvia, Cisneros, Jose Antonio, Almazan, Guillermina, Sánchez-Rodriguez, María Alejandra, Molina-Holgado, Francisco, Molina-Holgado, Eduardo

“…Endocannabinoids have recently emerged as instructive cues in the developing central nervous system, and, based on the expression of their receptors, we…”
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The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation by Doukhanine, Evgueni, Gavino, Christina, Haines, Jeffery D, Almazan, Guillermina, Richard, Stéphane

“…The quaking viable (qk(v)) mice represent an animal model of dysmyelination. The absence of expression of the QKI-6 and QKI-7 cytoplasmic isoforms in…”
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Mitogen-activated protein kinase p38 regulates krox-20 to direct schwann cell differentiation and peripheral myelination by Hossain, Shireen, de la Cruz-Morcillo, Miguel-Angel, Sanchez-Prieto, Ricardo, Almazan, Guillermina

“…We previously reported that addition of extracellular matrix (ECM) extracts to rat Schwann cell‐dorsal root ganglion neuron (DRGN) co‐cultures activated…”
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Obituary of Theodore L. Sourkes, PhD, FRSC, OC by Young, Simon, PhD, Quik, Maryka, PhD, Almazan, Guillermina, PhD, Ekker, Marc, PhD

“…With the death of Theodore L. Sourkes on Jan 17, 2015, at age 95, the CCNP, Canada and the international research community lost one of the pioneers of a…”
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The QKI-6 RNA binding protein localizes with the MBP mRNAs in stress granules of glial cells by Wang, Yunling, Lacroix, Geneviève, Haines, Jeffery, Doukhanine, Evgueni, Almazan, Guillermina, Richard, Stéphane

“…The quaking viable (qk(v)) mouse has several developmental defects that result in rapid tremors in the hind limbs. The qkI gene expresses three major…”
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The QKI-6 and QKI-7 RNA binding proteins block proliferation and promote Schwann cell myelination by Larocque, Daniel, Fragoso, Gabriela, Huang, Jinghan, Mushynski, Walter E, Loignon, Martin, Richard, Stéphane, Almazan, Guillermina

“…The quaking viable (qk(v)) mice have uncompacted myelin in their central and peripheral nervous system (CNS, PNS). The qk gene encodes 3 major alternatively…”
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Nuclear Retention of MBP mRNAs in the Quaking Viable Mice by Larocque, Daniel, Pilotte, Julie, Chen, Taiping, Cloutier, Frank, Massie, Bernard, Pedraza, Liliana, Couture, Réjean, Lasko, Paul, Almazan, Guillermina, Richard, Stéphane

“…Quaking viable ( qk v ) mice fail to properly compact myelin in their central nervous systems. Although the defect in the qk v mice involves a mutation…”
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Mitogen-activated protein kinase activated protein kinase 2 (MK2) participates in p38 MAPK regulated control of oligodendrocyte differentiation by Haines, Jeffery D., Fang, Jun, Mushynski, Walter E., Almazan, Guillermina

“…The p38 mitogen‐activated protein kinases (p38 MAPKs) are a family of kinases that regulate a number of cellular functions including cell migration,…”
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Human fetal oligodendrocyte progenitor cells from different gestational stages exhibit substantially different potential to myelinate by Cui, Qiao-Ling, D'Abate, Lia, Fang, Jun, Leong, Soo Yuen, Ludwin, Samuel, Kennedy, Timothy E, Antel, Jack, Almazan, Guillermina

“…To investigate age-related intrinsic regulation of the capacity of human fetal oligodendrocyte progenitor cells (OPCs) to myelinate, potential OPCs were…”
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Localization of Functional Prostaglandin E2 Receptors EP3 and EP4 in the Nuclear Envelope by Bhattacharya, Mousumi, Peri, Krishna, Ribeiro-da-Silva, Alfredo, Almazan, Guillermina, Shichi, Hitoshi, Hou, Xin, Varma, Daya R., Chemtob, Sylvain

“…The effects of prostaglandin E2are thought to be mediated via G protein-coupled plasma membrane receptors, termed EP. However recent data implied that…”
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Developmental differences in H2O2‐induced oligodendrocyte cell death: role of glutathione, mitogen‐activated protein kinases and caspase 3 by Fragoso, Gabriela, Martínez‐Bermúdez, Ana Katherine, Liu, Hsueh‐Ning, Khorchid, Amani, Chemtob, Sylvain, Mushynski, Walter E., Almazan, Guillermina

“…The molecular mechanisms underlying H2O2‐induced toxicity were characterized in rat oligodendrocyte cultures. While progenitor cells were more sensitive than…”
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Nuclear localization of prostaglandin E2 receptors by Bhattacharya, M, Peri, K G, Almazan, G, Ribeiro-da-Silva, A, Shichi, H, Durocher, Y, Abramovitz, M, Hou, X, Varma, D R, Chemtob, S

“…Prostaglandin E 2 receptors (EP) were detected by radioligand binding in nuclear fractions isolated from porcine brain and myometrium. Intracellular…”
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AMPA receptor‐mediated toxicity in oligodendrocyte progenitors involves free radical generation and activation of JNK, calpain and caspase 3 by Liu, Hsueh‐Ning, Giasson, Benoit I., Mushynski, Walter E., Almazan, Guillermina

“…The molecular mechanisms underlying AMPA (α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate) receptor‐mediated excitotoxicity were characterized in rat…”
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