Prediction of Fibrosis Progression Rate in Patients with Chronic Hepatitis C Genotype 4: Role of Cirrhosis Risk Score and Host Factors

Prediction of Fibrosis Progression Rate in Patients with Chronic Hepatitis C Genotype 4: Role of Cirrhosis Risk Score and Host Factors

The rate of liver fibrosis progression in chronic hepatitis C (CHC) patients is highly variable and affected by different factors. This study aimed to assess the role of cirrhosis risk score (CRS) based on 7 genetic variants (7 single-nucleotide polymorphisms [SNPs]) and host factors (age and sex) i...

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Bibliographic Details
Published in:Journal of interferon & cytokine research Vol. 37; no. 3; p. 97
Main Authors: Besheer, Tarek, El-Bendary, Mahmoud, Elalfy, Hatem, Abd El-Maksoud, Mohamed, Salah, Mohamed, Zalata, Khaled, Elkashef, Wagdi, Elshahawy, Heba, Raafat, Doaa, Elemshaty, Wafaa, Almashad, Noha, Zaghloul, Hosam, El-Gilany, Abdel-Hady, Abdel Razek, Ahmed Abdel Khalek, Abd Elwahab, Mohamed
Format: Journal Article
Language:English
Published: United States 01-03-2017
Subjects:
Adolescent
Adult
Aged
Biomarkers
Biopsy
Disease Progression
Female
Genotype
Hepacivirus - genetics
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - virology
Host-Pathogen Interactions
Humans
Liver Cirrhosis - diagnosis
Liver Cirrhosis - epidemiology
Liver Cirrhosis - etiology
Liver Function Tests
Male
Middle Aged
Prognosis
Risk Assessment
Time Factors
Young Adult
cirrhosis risk score
fibrosis progression
host factors
CHC
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Summary:The rate of liver fibrosis progression in chronic hepatitis C (CHC) patients is highly variable and affected by different factors. This study aimed to assess the role of cirrhosis risk score (CRS) based on 7 genetic variants (7 single-nucleotide polymorphisms [SNPs]) and host factors (age and sex) in the prediction of the rate of fibrosis progression in CHC. Duration of infection was determined in 115 patients. The fibrosis progression rate (FPR) per year was calculated as the ratio between fibrosis stage and the duration of infection. SNP genotyping were performed and CRS was determined based on it. FPR was significantly elevated in patients who acquired infection at age >40 years versus those who acquired infection at 30-40 years and those who acquired infection at <30 years. Median FPR was significantly higher in males than females (0.17 vs. 0.15) with P = 0.001. CRS value ≥0.8 is predictive of patients with high risk for cirrhosis, and CRS value <0.5 is predictive of patients with low risk for cirrhosis. There was significant positive correlation between CRS and FPR (P ≤ 0.001). CRS based on 7 SNPs at cutoff value ≥0.8, age at infection >40 years, and male sex are predictors of higher FPR.
ISSN:1557-7465
DOI:10.1089/jir.2016.0111