Search Results - "Almasan, A."

MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies by Choudhary, G S, Al-harbi, S, Mazumder, S, Hill, B T, Smith, M R, Bodo, J, Hsi, E D, Almasan, A

“…Overexpression of anti-apoptotic BCL-2 family members is a hallmark of many lymphoid malignancies, including chronic lymphocytic leukemia (CLL) and non-Hodgkin…”
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Correction to: MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies by Choudhary, G. S., Al-harbi, S., Mazumder, S., Hill, B. T., Smith, M. R., Bodo, J., Hsi, E. D., Almasan, A.

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Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells by Babcook, M A, Sramkoski, R M, Fujioka, H, Daneshgari, F, Almasan, A, Shukla, S, Nanavaty, R R, Gupta, S

“…Castration-resistant prostate cancer (CRPC) cells acquire resistance to chemotherapy and apoptosis, in part, due to enhanced aerobic glycolysis and biomass…”
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Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis by Chen, Q, Gong, B, Almasan, A

“…Cytochrome c (cyto c) release from mitochondria is a critical event in apoptosis. By investigating the ordering of molecular events during genotoxic…”
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BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells by Sharma, A, Singh, K, Mazumder, S, Hill, B T, Kalaycio, M, Almasan, A

“…The purine analog fludarabine (Fd) is an essential therapeutic for chronic lymphocytic leukemia (CLL). Innate or acquired resistance to Fd is a significant…”
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Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor by Ray, S, Bucur, O, Almasan, A

“…Overexpression of anti-apoptotic Bcl-2 family proteins may play an important role in the aggressive behavior of prostate cancer cells and their resistance to…”
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The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction by Chen, Q, Chai, Y-C, Mazumder, S, Jiang, C, Macklis, R M, Chisolm, G M, Almasan, A

“…Mitochondria play central roles in cellular metabolism and apoptosis and are a major source of reactive oxygen species (ROS). We investigated the role of ROS…”
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Apo2 ligand/TNF-related apoptosis-inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells by BENDI GONG, ALMASAN, Alex

“…Ionizing radiation is a major tool for cancer treatment. The response of eukaryotic cells to ionizing radiation includes apoptosis, a process which requires…”
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Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications by Bucur, O, Stancu, A L, Khosravi-Far, R, Almasan, A

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E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma by CROSBY, M. E, JACOBBERGER, J, GUPTA, D, MACKLIS, R. M, ALMASAN, A

“…The retinoblastoma (pRB) family proteins regulate the E2F transcription factors; their complexes regulate critical transitions through the cell cycle. The…”
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Deficiency of Retinoblastoma Protein Leads to Inappropriate S-Phase Entry, Activation of E2F-Responsive Genes, and Apoptosis by Almasan, Alexandru, Yin, Yuxin, Kelly, Ruth E., Eva Y.-H. P. Lee, Bradley, Allan, Li, Weiwei, Bertino, Joseph R., Wahl, Geoffrey M.

“…The retinoblastoma susceptibility gene (Rb) participates in controlling the G1/S-phase transition, presumably by binding and inactivating E2F transcription…”
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Cellular Commitment to Radiation-Induced Apoptosis by Almasan, Alex

“…Almasan, A. Cellular Commitment to Radiation-Induced Apoptosis. The basic elements of the machinery of programmed cell death (apoptosis) are built into all…”
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Apoptosis of multiple myeloma by Oancea, Marcela, Mani, Aruna, Hussein, Mohamad A, Almasan, Alexandru

“…Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells. MM cells localize to the bone marrow, where cell adhesion-mediated autocrine…”
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Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy by Almasan, Alexandru, Ashkenazi, Avi

“…Apo2 ligand or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL) is one of several members of the TNF gene superfamily that induce…”
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Lack of Functional Retinoblastoma Protein Mediates Increased Resistance to Antimetabolites in Human Sarcoma Cell Lines by Li, Weiwei, Fan, Jianguo, Hochhauser, Daniel, Banerjee, Debabrata, Zielinski, Zbigniew, Almasan, Alex, Yin, Yuxin, Kelly, Ruth, Wahl, Geofrey M., Bertino, Joseph R.

“…Growth inhibition assays indicated that the IC50values for methotrexate (MTX) and 5-fluorodeoxyuridine (FdUrd) in HS-18, a liposarcoma cell line lacking…”
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Genetic instability as a consequence of inappropriate entry into and progression through S-phase by Almasan, A, Linke, S P, Paulson, T G, Huang, L C, Wahl, G M

“…The stability of the mammalian genome depends on the proper function of G1 and G2 cell cycle control mechanisms. Two tumor suppressors, p53 and retinoblastoma…”
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Development of venetoclax for therapy of lymphoid malignancies by Zhu, Huayuan, Almasan, Alexandru

“…B-cell lymphoma-2 (BCL-2) family dysfunction and impairment of apoptosis are common in most B-cell lymphoid malignancies. Venetoclax (Venclexta™, formerly…”
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Apoptosis induction in prostate cancer cells and xenografts by combined treatment with Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand and CPT-11 by RAY, Subrata, ALMASAN, Alex

“…Because apoptosis is deregulated in most cancers, apoptosis-modulating approaches offer an attractive opportunity for clinical therapy of many tumors,…”
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Recombination by sequence repeats with formation of suppressive or residual mitochondrial DNA in Neurospora by Almasan, A. (The Salk Institute for Biological Studies, San Diego, CA), Mishra, N.C

“…Recombination junctions of several Neurospora mitochondrial DNA (mtDNA) mutants and their revertants were identified. Their nucleotide sequences and putative…”
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Chromosomal localization of the human retinoid X receptors by Almasan, A, Mangelsdorf, D J, Ong, E S, Wahl, G M, Evans, R M

“…The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin…”
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