Search Results - "Almansour, Nahlah Makki"

Cheminformatics and biomolecular dynamics studies towards the discovery of anti-staphylococcal nuclease domain-containing 1 (SND1) inhibitors to treat metastatic breast cancer by Makki Almansour, Nahlah

“…Metastatic breast cancer is a prime health concern and leading health burden across the globe. Previous efforts have shown that protein–protein interaction…”
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Triple-Negative Breast Cancer: A Brief Review About Epidemiology, Risk Factors, Signaling Pathways, Treatment and Role of Artificial Intelligence by Almansour, Nahlah Makki

“…Triple-negative breast cancer (TNBC) is a kind of breast cancer that lacks estrogen, progesterone, and human epidermal growth factor receptor 2. This cancer is…”
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Repurposing potential of posaconazole and grazoprevir as inhibitors of SARS-CoV-2 helicase by Abidi, Syed Hani, Almansour, Nahlah Makki, Amerzhanov, Daulet, Allemailem, Khaled S., Rafaqat, Wardah, Ibrahim, Mahmoud A. A., la Fleur, Philip, Lukac, Martin, Ali, Syed

“…As the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic engulfs millions worldwide, the quest for vaccines or drugs against the virus…”
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Immunoinformatics- and Bioinformatics-Assisted Computational Designing of a Novel Multiepitopes Vaccine Against Cancer-Causing Merkel Cell Polyomavirus by Almansour, Nahlah Makki

“…Merkel cell polyomavirus (MCV) contains double-stranded DNA as its genome and is the fifth polyomavirus that infects humans. The virus causes Merkel cell…”
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Computational exploration of maternal embryonic leucine zipper kinase (MELK) as a cancer drug target by Makki Almansour, Nahlah

“…Maternal embryonic leucine zipper kinase (MELK) is of vital importance due to its significant role in cancer development and its association with poor…”
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Single nucleotide polymorphisms (SNPs) in prostate cancer: its implications in diagnostics and therapeutics by Allemailem, Khaled S, Almatroudi, Ahmad, Alrumaihi, Faris, Makki Almansour, Nahlah, Aldakheel, Fahad M, Rather, Rafiq Ahmad, Afroze, Dil, Rah, Bilal

“…Prostate cancer is one of the most frequently diagnosed malignancies in developed countries and approximately 248,530 new cases of prostate cancer are likely…”
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In Silico Mining of Natural Products Atlas (NPAtlas) Database for Identifying Effective Bcl-2 Inhibitors: Molecular Docking, Molecular Dynamics, and Pharmacokinetics Characteristics by Almansour, Nahlah Makki, Allemailem, Khaled S, Abd El Aty, Abeer Abas, Ismail, Ekram Ismail Fagiree, Ibrahim, Mahmoud A A

“…The Bcl-2 protein has a vital function in controlling the programmed cell doom of mitochondria. If programmed cell death signals are obstructed, an imbalance…”
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In Silico Targeting Human Multidrug Transporter ABCG2 in Breast Cancer: Database Screening, Molecular Docking, and Molecular Dynamics Study by Ibrahim, Mahmoud A. A., Badr, Esraa A. A., Abdelrahman, Alaa H. M., Almansour, Nahlah Makki, Mekhemer, Gamal A. H., Shawky, Ahmed M., Moustafa, Mahmoud F., Atia, Mohamed A. M.

“…ABCG2 is a substantial member of the ABC transporter superfamily that plays a significant role in multidrug resistance in cancer. Until recently, the 3D…”
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Lipid-Based Nanoparticle Formulation of Diallyl Trisulfide Chemosensitizes the Growth Inhibitory Activity of Doxorubicin in Colorectal Cancer Model: A Novel In Vitro, In Vivo and In Silico Analysis by Alrumaihi, Faris, Khan, Masood Alam, Babiker, Ali Yousif, Alsaweed, Mohammed, Azam, Faizul, Allemailem, Khaled S, Almatroudi, Ahmad A, Ahamad, Syed Rizwan, Alsugoor, Mahdi H, Alharbi, Khloud Nawaf, Almansour, Nahlah Makki, Khan, Arif

“…Garlic's main bioactive organosulfur component, diallyl trisulfide (DATS), has been widely investigated in cancer models. However, DATS is not suitable for…”
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Structural Dynamics of P-Rex1 Complexed with Natural Leads Establishes the Protein as an Attractive Target for Therapeutics to Suppress Cancer Metastasis by Hameed, Alaa R., Ali, Sama Fakhri, Alsallameh, Sarah M. S., Muhseen, Ziyad Tariq, Almansour, Nahlah Makki, ALSuhaymi, Naif, Alsugoor, Mahdi H., Allemailem, Khaled S.

“…Phosphatidylinositol 3,4,5-trisphosphate- (PIP3-) dependent Rac exchanger 1 (P-Rex1) functions as Rho guanine nucleotide exchange factor and is activated by…”
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Prospective Drug Candidates as Human Multidrug Transporter ABCG2 Inhibitors: an In Silico Drug Discovery Study by Ibrahim, Mahmoud A. A., Badr, Esraa A. A., Abdelrahman, Alaa H. M., Almansour, Nahlah Makki, Shawky, Ahmed M., Mekhemer, Gamal A. H., Alrumaihi, Faris, Moustafa, Mahmoud F., Atia, Mohamed A. M.

“…Breast cancer resistance protein (ABCG2) is a human ATP-binding cassette (ABC) that plays a paramount role in multidrug resistance (MDR) in cancer therapy. The…”
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TFAP2B, AP-1 and JAZF1 Expression in Tissues of Papillary Thyroid Carcinoma Patients; Clinical, Pathological and Prognostic Values by Abuderman, Abdulwahab A, Harb, Ola A, Gertallah, Loay M, Almansour, Nahlah Makki

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Ajwa-Dates (Phoenix dactylifera)-Mediated Synthesis of Silver Nanoparticles and Their Anti-Bacterial, Anti-Biofilm, and Cytotoxic Potential by Allemailem, Khaled S., Khadri, Habeeb, Azam, Mohd, Khan, Masood Alam, Rahmani, Arshad Husain, Alrumaihi, Faris, Khateef, Riazunnisa, Ansari, Mohammad Azam, Alatawi, Eid A., Alsugoor, Mahdi H., Almansour, Nahlah Makki, Alhatlani, Bader Y., Almatroudi, Ahmad

“…Green nanotechnology is the evolution of cost-effective and environmentally friendly processes for the production of metal-based nanoparticles due to medicinal…”
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Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways by Rahmani, Arshad Husain, Almatroudi, Ahmad, Allemailem, Khaled S, Alharbi, Hajed Obaid A, Alwanian, Wanian M, Alhunayhani, Basmah Awwadh, Algahtani, Mohammad, Theyab, Abdulrahman, Almansour, Nahlah Makki, Algefary, Ahmed N, Aldeghaim, Solaiman Saleh Ali, Khan, Amjad Ali

“…Cancer is a major public health concern worldwide in terms of mortality. The exact reason behind the development of cancer is not understood clearly, but it is…”
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Identification of promising inhibitors against breast cancer disease by targeting NUDIX hydrolase 5 (NUDT5) biomolecule by Almansour, Nahlah Makki

“…It is well documented that NUDT5 enzyme inhibition in breast cancer cell lines arrest cancer cells growth, invasiveness and migration. The NUDT5 enzyme…”
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In silico drug repurposing and lipid bilayer molecular dynamics puzzled out potential breast cancer resistance protein (BCRP/ABCG2) inhibitors by Almansour, Nahlah Makki, Abdelrahman, Alaa H. M., Ismail Fagiree, Ekram, Ibrahim, Mahmoud A. A.

“…Multidrug resistance (MDR) is a fundamental reason for the fiasco of carcinoma chemotherapy. A wide variety of anticarcinoma drugs are expelled from neoplasm…”
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Innovative Strategies of Reprogramming Immune System Cells by Targeting CRISPR/Cas9-Based Genome-Editing Tools: A New Era of Cancer Management by Allemailem, Khaled S, Alsahli, Mohammed A, Almatroudi, Ahmad, Alrumaihi, Faris, Al Abdulmonem, Waleed, Moawad, Amira A, Alwanian, Wanian, Almansour, Nahlah Makki, Rahmani, Arshad Husain, Khan, Amjad Ali

“…The recent developments in the study of clustered regularly interspaced short palindromic repeats/associated protein 9 (CRISPR/Cas9) system have revolutionized…”
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Naturally occurring plant-based anticancerous candidates as prospective ABCG2 inhibitors: an in silico drug discovery study by Ibrahim, Mahmoud A. A., Abdelrahman, Alaa H. M., Badr, Esraa A. A., Almansour, Nahlah Makki, Alzahrani, Othman R., Ahmed, Muhammad Naeem, Soliman, Mahmoud E. S., Naeem, Mohamed Ahmed, Shawky, Ahmed M., Sidhom, Peter A., Mekhemer, Gamal A. H., Atia, Mohamed A. M.

“…ATP-binding cassette transporter G2 (ABCG2) is an efflux transporter related to the clinical multidrug resistance (MDR) phenomenon. Identifying ABCG2…”
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Venetoclax analogs as promising anticancer therapeutics via targeting Bcl-2 protein: in-silico drug discovery study by Almansour, Nahlah Makki, Allemailem, Khaled S, Abd El Aty, Abeer Abas, Boussoufa, Dhouha, Ismail Fagiree, Ekram, Ibrahim, Mahmoud A A

“…B-cell lymphoma 2 (Bcl-2) protein plays a vital role in enhancing malignant cell survival by alleviating programmed cell death. Therefore, Bcl-2 protein has…”
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