Partial mole with a diploid fetus: case study and literature review

To describe an extremely rare case of a partial hydatidiform mole with a normal fetus. The etiology and clinical management of this entity are discussed. Case report. We describe a rare case of partial mole and a living fetus of diploid karyotype and biparental origin confirmed by flow cytometry and...

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Bibliographic Details
Published in:	Fetal diagnosis and therapy Vol. 25; no. 3; p. 354
Main Authors:	Sánchez-Ferrer, María Luisa, Ferri, Belén, Almansa, María Teresa, Carbonel, Pablo, López-Expósito, Isabel, Minguela, Alfredo, Abad, Lorenzo, Parrilla, Juan José
Format:	Journal Article
Language:	English
Published:	Switzerland 01-01-2009
Subjects:	Abortion, Spontaneous Adult Chorionic Gonadotropin, beta Subunit, Human - blood Diploidy Female Fetus Humans Hydatidiform Mole - blood Hydatidiform Mole - diagnostic imaging Pregnancy Ultrasonography
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Summary:	To describe an extremely rare case of a partial hydatidiform mole with a normal fetus. The etiology and clinical management of this entity are discussed. Case report. We describe a rare case of partial mole and a living fetus of diploid karyotype and biparental origin confirmed by flow cytometry and PCR techniques. No malformations were observed, beta-hCG levels were high (>100,000 mIU/ml) and persistent trophoblastic disease did eventually occur. A suspected partial mole on ultrasound with increased beta-hCG and a sonographically normal living fetus of a diploid karyotype poses a dilemma for clinical management. Termination of pregnancy is not indicated if the fetus is normal; in fact, continuation to birth is possible in nearly 60% of cases with no increase in maternal risks when the patient is closely monitored after birth until beta-hCG is negative. In the case presented, however, a spontaneous abortion occurred at 21 weeks' gestation, possibly as a result of the amniocentesis.
ISSN:	1421-9964
DOI:	10.1159/000235885