Search Results - "Alman, Benjamin A."

Cutaneous wound healing: recruiting developmental pathways for regeneration by Bielefeld, Kirsten A., Amini-Nik, Saeid, Alman, Benjamin A.

“…Following a skin injury, the damaged tissue is repaired through the coordinated biological actions that constitute the cutaneous healing response. In mammals,…”
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The origins and roles of osteoclasts in bone development, homeostasis and repair by Yahara, Yasuhito, Nguyen, Tuyet, Ishikawa, Koji, Kamei, Katsuhiko, Alman, Benjamin A

“…The mechanisms underlying bone development, repair and regeneration are reliant on the interplay and communication between osteoclasts and other surrounding…”
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Mechanism of hard-nanomaterial clearance by the liver by Tsoi, Kim M., MacParland, Sonya A., Ma, Xue-Zhong, Spetzler, Vinzent N., Echeverri, Juan, Ouyang, Ben, Fadel, Saleh M., Sykes, Edward A., Goldaracena, Nicolas, Kaths, Johann M., Conneely, John B., Alman, Benjamin A., Selzner, Markus, Ostrowski, Mario A., Adeyi, Oyedele A., Zilman, Anton, McGilvray, Ian D., Chan, Warren C. W.

“…The liver and spleen are major biological barriers to translating nanomedicines because they sequester the majority of administered nanomaterials and prevent…”
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Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone Homeostasis by Vi, Linda, Baht, Gurpreet S, Whetstone, Heather, Ng, Adeline, Wei, Qingxia, Poon, Raymond, Mylvaganam, Sivakami, Grynpas, Marc, Alman, Benjamin A

“…ABSTRACT Macrophages are activated in inflammation and during early phases of repair processes. Interestingly, they are also present in bone during…”
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Are Quantum Dots Toxic? Exploring the Discrepancy Between Cell Culture and Animal Studies by Tsoi, Kim M, Dai, Qin, Alman, Benjamin A, Chan, Warren C. W

“…Despite significant interest in developing quantum dots (QDs) for biomedical applications, many researchers are convinced that QDs will never be used for…”
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Wnt pathway, an essential role in bone regeneration by Chen, Yan, Alman, Benjamin A.

“…Fracture repair is a complex regenerative process initiated in response to injury, resulting in optimal restoration of skeletal function. Although histology…”
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Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation by Klingberg, Franco, Chow, Melissa L, Koehler, Anne, Boo, Stellar, Buscemi, Lara, Quinn, Thomas M, Costell, Mercedes, Alman, Benjamin A, Genot, Elisabeth, Hinz, Boris

“…Integrin-mediated force application induces a conformational change in latent TGF-β1 that leads to the release of the active form of the growth factor from the…”
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Generation of articular chondrocytes from human pluripotent stem cells by Craft, April M, Rockel, Jason S, Nartiss, Yulia, Kandel, Rita A, Alman, Benjamin A, Keller, Gordon M

“…Articular cartilage cells, which maintain synovial joints, are generated in culture from human pluripotent stem cells. The replacement of articular cartilage…”
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A Mechanism for Gene-Environment Interaction in the Etiology of Congenital Scoliosis by Sparrow, Duncan B., Chapman, Gavin, Smith, Allanceson J., Mattar, Muhammad Z., Major, Joelene A., O'Reilly, Victoria C., Saga, Yumiko, Zackai, Elaine H., Dormans, John P., Alman, Benjamin A., McGregor, Lesley, Kageyama, Ryoichiro, Kusumi, Kenro, Dunwoodie, Sally L.

“…Congenital scoliosis, a lateral curvature of the spine caused by vertebral defects, occurs in approximately 1 in 1,000 live births. Here we demonstrate that…”
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Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice by Vi, Linda, Baht, Gurpreet S., Soderblom, Erik J., Whetstone, Heather, Wei, Qingxia, Furman, Bridgette, Puviindran, Vijitha, Nadesan, Puviindran, Foster, Matthew, Poon, Raymond, White, James P., Yahara, Yasuhito, Ng, Adeline, Barrientos, Tomasa, Grynpas, Marc, Mosely, M. Arthur, Alman, Benjamin A.

“…The pace of repair declines with age and, while exposure to a young circulation can rejuvenate fracture repair, the cell types and factors responsible for…”
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Ultrafast mid-IR laser scalpel: protein signals of the fundamental limits to minimally invasive surgery by Amini-Nik, Saeid, Kraemer, Darren, Cowan, Michael L, Gunaratne, Keith, Nadesan, Puviindran, Alman, Benjamin A, Miller, R J Dwayne

“…Lasers have in principle the capability to cut at the level of a single cell, the fundamental limit to minimally invasive procedures and restructuring…”
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Single cell analysis of Idh mutant growth plates identifies cell populations responsible for longitudinal bone growth and enchondroma formation by Puviindran, Vijitha, Shimada, Eijiro, Huang, Zeyu, Ma, Xinyi, Ban, Ga I., Xiang, Yu, Zhang, Hongyuan, Ou, Jianhong, Wei, Xiaolin, Nakagawa, Makoto, Martin, John, Diao, Yarui, Alman, Benjamin A.

“…Enchondromas are a common tumor in bone that can occur as multiple lesions in enchondromatosis, which is associated with deformity of the affected bone. These…”
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Osteoid Osteoma and Osteoblastoma by Atesok, Kivanc I, Alman, Benjamin A, Schemitsch, Emil H, Peyser, Amos, Mankin, Henry

“…Osteoid osteoma and osteoblastoma are commonly seen benign osteogenic bone neoplasms. Both tumors are typically seen in the second decade of life, with a…”
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Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage by Ali, Shabana Amanda, Al‐Jazrawe, Mushriq, Ma, Henry, Whetstone, Heather, Poon, Raymond, Farr, Sarah, Naples, Mark, Adeli, Khosrow, Alman, Benjamin A.

“…Objective With no effective therapies to attenuate cartilage degeneration in osteoarthritis (OA), the result is pain and disability. Activation of hedgehog…”
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Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing by Chen, Yan, Whetstone, Heather C, Lin, Alvin C, Nadesan, Puviindran, Wei, Qingxia, Poon, Raymond, Alman, Benjamin A

“…Delayed fracture healing causes substantial disability and usually requires additional surgical treatments. Pharmacologic management to improve fracture repair…”
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Monocyte/Macrophage Lineage Cells From Fetal Erythromyeloid Progenitors Orchestrate Bone Remodeling and Repair by Yahara, Yasuhito, Ma, Xinyi, Gracia, Liam, Alman, Benjamin A

“…A third of the population sustains a bone fracture, and the pace of fracture healing slows with age. The slower pace of repair is responsible for the increased…”
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Specification of chondrocytes and cartilage tissues from embryonic stem cells by Craft, April M, Ahmed, Nazish, Rockel, Jason S, Baht, Gurpreet S, Alman, Benjamin A, Kandel, Rita A, Grigoriadis, Agamemnon E, Keller, Gordon M

“…Osteoarthritis primarily affects the articular cartilage of synovial joints. Cell and/or cartilage replacement is a promising therapy, provided there is access…”
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Mutant IDH is sufficient to initiate enchondromatosis in mice by Hirata, Makoto, Sasaki, Masato, Cairns, Rob A, Inoue, Satoshi, Puviindran, Vijitha, Li, Wanda Y, Snow, Bryan E, Jones, Lisa D, Wei, Qingxia, Sato, Shingo, Tang, Yuning J, Nadesan, Puviindran, Rockel, Jason, Whetstone, Heather, Poon, Raymond, Weng, Angela, Gross, Stefan, Straley, Kimberly, Gliser, Camelia, Xu, Yingxia, Wunder, Jay, Mak, Tak W, Alman, Benjamin A

“…Significance Current genomic and biochemical analysis revealed mutations in isocitrate dehydrogenase ( IDH ) genes associated with several neoplasms and a…”
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Efficacy of auranofin as an inhibitor of desmoid progression by Ito, Kan, Nishida, Yoshihiro, Hamada, Shunsuke, Shimizu, Koki, Sakai, Tomohisa, Ohkawara, Bisei, Alman, Benjamin A., Enomoto, Atsushi, Ikuta, Kunihiro, Koike, Hiroshi, Zhang, Jiarui, Ohno, Kinji, Imagama, Shiro

“…Anticancer drugs and molecular targeted therapies are used for refractory desmoid-type fibromatosis (DF), but occasionally cause severe side effects. The…”
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Aggressive Fibromatosis (Desmoid Tumor) Is Derived from Mesenchymal Progenitor Cells by WU, Colleen, NIK-AMINI, Saied, NADESAN, Puviindran, STANFORD, William L, ALMAN, Benjamin A

“…The cellular origins from which most tumors arise are poorly defined, especially in mesenchymal neoplasms. Aggressive fibromatosis, also known as desmoid…”
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