Secondary Metabolites of the Genus Didemnum : A Comprehensive Review of Chemical Diversity and Pharmacological Properties

Secondary Metabolites of the Genus Didemnum : A Comprehensive Review of Chemical Diversity and Pharmacological Properties

Tunicates (ascidians) are common marine invertebrates that are an exceptionally important source of natural products with biomedical and pharmaceutical applications, including compounds that are used clinically in cancers. Among tunicates, the genus is important because it includes the most species,...

Full description

Saved in:
Bibliographic Details
Published in:Marine drugs Vol. 18; no. 6; p. 307
Main Authors: Youssef, Diaa T A, Almagthali, Hadeel, Shaala, Lamiaa A, Schmidt, Eric W
Format: Journal Article
Language:English
Published: Switzerland MDPI 11-06-2020
MDPI AG
Subjects:
Animals
Aquatic Organisms
ascidian
Biological Products
chemical diversity
genus Didemnum
natural product
Review
Secondary Metabolism
secondary metabolite
Species Specificity
tunicate
Urochordata - chemistry
biological properties
chemical diversity
natural product
tunicate
genus Didemnum
ascidian
secondary metabolite
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tunicates (ascidians) are common marine invertebrates that are an exceptionally important source of natural products with biomedical and pharmaceutical applications, including compounds that are used clinically in cancers. Among tunicates, the genus is important because it includes the most species, and it belongs to the most speciose family (Didemnidae). The genus includes the species , , , and , as well as others, which are well known for their chemically diverse secondary metabolites. To date, investigators have reported secondary metabolites, usually including bioactivity data, for at least 69 members of the genus , leading to isolation of 212 compounds. Many of these compounds exhibit valuable biological activities in assays targeting cancers, bacteria, fungi, viruses, protozoans, and the central nervous system. This review highlights compounds isolated from genus through December 2019. Chemical diversity, pharmacological activities, geographical locations, and applied chemical methods are described.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1660-3397
1660-3397
DOI:10.3390/md18060307