Search Results - "Alméciga, Carlos J."

Therapeutic Options for Mucopolysaccharidoses: Current and Emerging Treatments by Sawamoto, Kazuki, Stapleton, Molly, Alméciga-Díaz, Carlos J., Espejo-Mojica, Angela J., Losada, Juan Camilo, Suarez, Diego A., Tomatsu, Shunji

“…Mucopolysaccharidoses (MPS) are inborn errors of metabolism produced by a deficiency of one of the enzymes involved in the degradation of glycosaminoglycans…”
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Evidence of epigenetic landscape shifts in mucopolysaccharidosis IIIB and IVA by Vargas-López, Viviana, Prada, Luisa F., Alméciga-Díaz, Carlos J.

“…Lysosomal storage diseases (LSDs) are a group of monogenic diseases characterized by mutations in genes coding for proteins associated with the lysosomal…”
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CRISPR-Cas9 approach confirms Calcineurin-responsive zinc finger 1 (Crz1) transcription factor as a promising therapeutic target in echinocandin-resistant Candida glabrata by Ceballos-Garzon, Andres, Roman, Elvira, Pla, Jesús, Pagniez, Fabrice, Amado, Daniela, Alméciga-Díaz, Carlos J, Le Pape, Patrice, Parra-Giraldo, Claudia M

“…Invasive fungal infections, which kill more than 1.6 million patients each year worldwide, are difficult to treat due to the limited number of antifungal drugs…”
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Advances in the Development of Pharmacological Chaperones for the Mucopolysaccharidoses by Losada Díaz, Juan Camilo, Cepeda Del Castillo, Jacobo, Rodriguez-López, Edwin Alexander, Alméciga-Díaz, Carlos J

“…The mucopolysaccharidoses (MPS) are a group of 11 lysosomal storage diseases (LSDs) produced by mutations in the enzymes involved in the lysosomal catabolism…”
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Human recombinant lysosomal β‐Hexosaminidases produced in Pichia pastoris efficiently reduced lipid accumulation in Tay‐Sachs fibroblasts by Espejo‐Mojica, Angela J., Rodríguez‐López, Alexander, Li, Rong, Zheng, Wei, Alméciga‐Díaz, Carlos J., Dulcey‐Sepúlveda, Cindy, Combariza, Germán, Barrera, Luis A.

“…GM2 gangliosidosis, Tay‐Sachs and Sandhoff diseases, are lysosomal storage disorders characterized by the lysosomal accumulation of GM2 gangliosides. This…”
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Production of Trametes pubescens laccase under submerged and semi-solid culture conditions on agro-industrial wastes by Gonzalez, Juan C, Medina, Sandra C, Rodriguez, Alexander, Osma, Johann F, Alméciga-Díaz, Carlos J, Sánchez, Oscar F

“…Laccases are copper-containing enzymes involved in the degradation of lignocellulosic materials and used in the treatment of phenol-containing wastewater. In…”
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Improvement in the production of the human recombinant enzyme N-acetylgalactosamine-6-sulfatase (rhGALNS) in Escherichia coli using synthetic biology approaches by Reyes, Luis H., Cardona, Carolina, Pimentel, Luisa, Rodríguez-López, Alexander, Alméciga-Díaz, Carlos J.

“…Previously, we demonstrated production of an active recombinant human N-acetylgalactosamine-6-sulfatase (rhGALNS) enzyme in Escherichia coli as a potential…”
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Recombinant human N-acetylgalactosamine-6-sulfate sulfatase (GALNS) produced in the methylotrophic yeast Pichia pastoris by Rodríguez-López, Alexander, Alméciga-Díaz, Carlos J., Sánchez, Jhonnathan, Moreno, Jefferson, Beltran, Laura, Díaz, Dennis, Pardo, Andrea, Ramírez, Aura María, Espejo-Mojica, Angela J., Pimentel, Luisa, Barrera, Luis A.

“…Mucopolysaccharidosis IV A (MPS IV A, Morquio A disease) is a lysosomal storage disease (LSD) produced by mutations on N-acetylgalactosamine-6-sulfate…”
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Bromocriptine as a Novel Pharmacological Chaperone for Mucopolysaccharidosis IV A by Olarte-Avellaneda, Sergio, Cepeda Del Castillo, Jacobo, Rojas-Rodriguez, Andrés Felipe, Sánchez, Oscar, Rodríguez-López, Alexander, Suárez García, Diego A, Pulido, Luz Mary Salazar, Alméciga-Díaz, Carlos J

“…Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disease caused by mutations in the gene encoding for the enzyme N-acetylgalactosamine-6-sulfate…”
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Generation of an induced pluripotent stem cell line (TRNDi005-A) from a Mucopolysaccharidosis Type IVA (MPS IVA) patient carrying compound heterozygous p.R61W and p.WT405del mutations in the GALNS gene by Li, Rong, Baskfield, Amanda, Beers, Jeanette, Zou, Jizhong, Liu, Chengyu, Alméciga-Díaz, Carlos J., Zheng, Wei

“…Mucopolysaccharidosis type IVA (MPS IVA) is a rare genetic disease caused by mutations in the GALNS gene and is inherited in an autosomal recessive manner…”
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Adeno-associated virus gene transfer in Morquio A disease - effect of promoters and sulfatase-modifying factor 1 by Alméciga-Díaz, Carlos J, Montaño, Adriana M, Tomatsu, Shunji, Barrera, Luis A

“…Mucopolysaccharidosis (MPS) IVA is an autosomal recessive disorder caused by deficiency of the lysosomal enzyme N-acetylgalatosamine-6-sulfate sulfatase…”
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Use of a neuron-glia genome-scale metabolic reconstruction to model the metabolic consequences of the Arylsulphatase a deficiency through a systems biology approach by Echeverri-Peña, Olga Y., Salazar-Barreto, Diego A., Rodríguez-Lopez, Alexander, González, Janneth, Alméciga-Díaz, Carlos J., Verano-Guevara, Cristian H., Barrera, Luis A.

“…Metachromatic leukodystrophy (MLD) is a human neurodegenerative disorder characterized by progressive damage on the myelin band in the nervous system. MLD is…”
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Development of Bone Targeting Drugs by Stapleton, Molly, Sawamoto, Kazuki, Alméciga-Díaz, Carlos J, Mackenzie, William G, Mason, Robert W, Orii, Tadao, Tomatsu, Shunji

“…The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that…”
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Evaluation of HIV–1 derived lentiviral vectors as transductors of Mucopolysaccharidosis type IV a fibroblasts by Puentes-Tellez, María Alejandra, Sánchez, Oscar F., Rojas-Rodriguez, Felipe, Benincore-Flórez, Eliana, Barbosa, Hector, Alméciga Díaz, Carlos J.

“…•HIV-1 derived lentiviral vectors were used to mediate the transduction of GALNS and SUMF1 cDNAs in MPS IVA fibroblasts.•Lentiviral vectors have…”
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Gene therapy for Mucopolysaccharidoses by Sawamoto, Kazuki, Chen, Hui-Hsuan, Alméciga-Díaz, Carlos J., Mason, Robert W., Tomatsu, Shunji

“…Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders (LSDs) caused by a deficiency of lysosomal enzymes, leading to a wide range of various…”
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Computational analysis of the fructosyltransferase enzymes in plants, fungi and bacteria by Alméciga-Díaz, Carlos J., Gutierrez, Ángela M., Bahamon, Isabella, Rodríguez, Alexander, Rodríguez, Mauro A., Sánchez, Oscar F.

“…Fructosyltransferases (FTases) are enzymes produced by plants, fungi, and bacteria, which are responsible for the synthesis of fructooligosaccharides. In this…”
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Mucopolysaccharidosis IVA and glycosaminoglycans by Khan, Shaukat, Alméciga-Díaz, Carlos J, Sawamoto, Kazuki, Mackenzie, William G, Theroux, Mary C, Pizarro, Christian, Mason, Robert W, Orii, Tadao, Tomatsu, Shunji

“…Mucopolysaccharidosis IVA (MPS IVA; Morquio A: OMIM 253000) is a lysosomal storage disease with an autosomal recessive trait caused by the deficiency of…”
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Characterization of a New Bacteriocin from Lactobacillus plantarum LE5 and LE27 Isolated from Ensiled Corn by Amortegui, Jairo, Rodríguez-López, Alexander, Rodríguez, Deicy, Carrascal, Ana K, Alméciga-Díaz, Carlos J, Melendez, Adelina del P, Sánchez, Oscar F

“…Bacteriocins are low molecular peptides with antimicrobial activity, which are of great interest as food bio-preservatives and for treating diseases caused by…”
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Characterization of a recombinant N-acetylgalactosamine-6-sulfate sulfatase produced in E. coli for enzyme replacement therapy of Morquio A disease by Mosquera, Angela, Rodríguez, Alexander, Soto, Carlos, Leonardi, Felice, Espejo, Angela, Sánchez, Oscar F., Alméciga-Díaz, Carlos J., Barrera, Luis A.

“…► rGALNS was extracellularly produced in Escherichia coli BL21. ► Purified enzyme showed a 0.21Umg−1 activity and a production yield of 0.78mgL−1. ► rGALNS…”
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Identification of the iduronate-2-sulfatase proteome in wild-type mouse brain by Cardona, Carolina, Benincore, Eliana, Pimentel, Natalia, Reyes, Luis H., Patarroyo, Camilo, Rodríguez-López, Alexander, Martin-Rufian, M., Barrera, Luis Alejandro, Alméciga-Díaz, Carlos J.

“…Iduronate-2-sulfatase (IDS) is a lysosomal enzyme involved in the metabolism of the glycosaminoglycans heparan (HS) and dermatan (DS) sulfate. Mutations on IDS…”
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