Photo‐Mediated Decarboxylative Ketonization of Atropic Acids with Sulfonyl Hydrazides: Direct Access to β‐Ketosulfones

An efficient formation of synthetically and biologically relevant β‐ketosulfones via a photo‐mediated decarboxylative ketonization of atropic acids was disclosed. The approach features metal‐free conditions, good functional group compatibility, readily available starting materials and the use of ubi...

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Bibliographic Details
Published in:	Advanced synthesis & catalysis Vol. 362; no. 10; pp. 2045 - 2051
Main Authors:	Chen, Jie, Allyson, Zoe G., Xin, Jing‐Rui, Guan, Zhi, He, Yan‐Hong
Format:	Journal Article
Language:	English
Published:	Heidelberg Wiley Subscription Services, Inc 12-05-2020
Subjects:	Atropic acids Decarboxy-lative ketonization Functional groups Hydrazides Oxidizing agents Photocatalysis Synthetic methods β-Ketosulfones
Online Access:	Get full text
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Summary:	An efficient formation of synthetically and biologically relevant β‐ketosulfones via a photo‐mediated decarboxylative ketonization of atropic acids was disclosed. The approach features metal‐free conditions, good functional group compatibility, readily available starting materials and the use of ubiquitous dioxygen as both oxygen source and oxidant. Furthermore, mechanistic studies reveal that the decarboxylative ketonization reaction proceeds via a radical mechanism and may involve a radical chain reaction.
ISSN:	1615-4150 1615-4169
DOI:	10.1002/adsc.201901525