Search Results - "Allsopp, R"

Cell-free DNA analysis in current cancer clinical trials: a review by Cisneros-Villanueva, M., Hidalgo-Pérez, L., Rios-Romero, M., Cedro-Tanda, A., Ruiz-Villavicencio, C. A., Page, K., Hastings, R., Fernandez-Garcia, D., Allsopp, R., Fonseca-Montaño, M. A., Jimenez-Morales, S., Padilla-Palma, V., Shaw, J. A., Hidalgo-Miranda, A.

“…Cell-free DNA (cfDNA) analysis represents a promising method for the diagnosis, treatment selection and clinical follow-up of cancer patients. Although its…”
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Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine‐rich loop by El‐Ajouz, S, Ray, D, Allsopp, RC, Evans, RJ

“…BACKGROUND AND PURPOSE The cysteine‐rich head region, which is adjacent to the proposed ATP‐binding pocket in the extracellular ligand‐binding loop of P2X…”
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Fetal Growth Restriction is Associated with Accelerated Telomere Shortening and Increased Expression of Cell Senescence Markers in the Placenta by Davy, P, Nagata, M, Bullard, P, Fogelson, N.S, Allsopp, R

“…Abstract A hallmark of fetal growth restriction (FGR) is restricted placental development and insufficient nutrient supply to the fetus. It has previously been…”
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The RNA Component of Human Telomerase by Feng, Junli, Funk, Walter D., Wang, Sy-Shi, Weinrich, Scott L., Avilion, Ariel A., Chiu, Choy-Pik, Adams, Robert R., Chang, Edwin, Allsopp, Richard C., Yu, Jinghua, Le, Siyuan, West, Michael D., Harley, Calvin B., Andrews, William H., Greider, Carol W., Villeponteau, Bryant

“…Eukaryotic chromosomes are capped with repetitive telomere sequences that protect the ends from damage and rearrangements. Telomere repeats are synthesized by…”
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Telomere Length Predicts Replicative Capacity of Human Fibroblasts by Allsopp, Richard C., Vaziri, Homayoun, Patterson, Christopher, Goldstein, Samuel, Younglai, Edward V., Futcher, A. Bruce, Greider, Carol W., Harley, Calvin B.

“…When human fibroblasts from different donors are grown in vitro, only a small fraction of the variation in their finite replicative capacity is explained by…”
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Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation by GREENBERG, R. A, ALLSOPP, R. C, CHIN, L, MORIN, G. B, DEPINHO, R. A

“…We have identified the mouse telomerase reverse transcriptase component (mTERT) and demonstrate both substantial sequence homology to the human ortholog…”
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Quality of life and health-related utility analysis of adults with moderate and severe atopic dermatitis treated with tacrolimus ointment vs. topical corticosteroids by Poole, CD, Chambers, C, Allsopp, R, Currie, CJ

“…Background  The purpose of this study was to measure change in quality of life (QoL) and estimate health‐related utility in adults with moderate and severe…”
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Evidence for a Mitotic Clock in Human Hematopoietic Stem Cells: Loss of Telomeric DNA with Age by Vaziri, Homayoun, Dragowska, Wieslawa, Allsopp, Richard C., Thomas, Terry E., Harley, Calvin B., Lansdorp, Peter M.

“…The proliferative life-span of the stem cells that sustain hematopoiesis throughout life is not known. It has been proposed that the sequential loss of…”
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Long Telomeres in the Mature Human Placenta by Allsopp, R, Shimoda, J, Easa, D, Ward, K

“…Abstract Objective To investigate whether telomere shortening may play a role in senescence of the placenta. Study design Villous tissue was collected from…”
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Death-associated protein kinase (DAPK1) in cerebral cortex of late-onset Alzheimer's disease patients and aged controls by Hainsworth, A. H., Allsopp, R. C., Jim, A., Potter, J. F., Lowe, J., Talbot, C. J., Prettyman, R. J.

“…A. H. Hainsworth, R. C. Allsopp, A. Jim, J. F. Potter, J. Lowe, C. J. Talbot and R. J. Prettyman (2010) Neuropathology and Applied Neurobiology36, 17–24…”
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Telomere end-replication problem and cell aging by Levy, M Z, Allsopp, R C, Futcher, A B, Greider, C W, Harley, C B

“…Since DNA polymerase requires a labile primer to initiate unidirectional 5'-3' synthesis, some bases at the 3' end of each template strand are not copied…”
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Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cells by Allsopp, Richard C, Cheshier, Samuel, Weissman, Irving L

“…Telomeres shorten in hematopoietic cells, including hematopoietic stem cells (HSCs), during aging and after transplantation, despite the presence of readily…”
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Organellar genomic characterization of Anunuuluaehu liula representing a new genus and species of Phyllophoraceae (Gigartinales, Rhodophyta) from the mesophotic zone of Hawai'i by Cabrera, Feresa P, Paiano, Monica O, Fumo, James T, Allsopp, Kazumi R, Smith, Celia M, Spalding, Heather L, Kosaki, Randall K, Sherwood, Alison R

“…Over the last 2 decades, routine collections in the Hawaiian Archipelago have expanded to mesophotic reefs, leading to the discovery of a new red algal genus…”
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Organellar genomic characterization of Anunuuluaehu liula representing a new genus and species of Phyllophoraceae (Gigartinales, Rhodophyta) from the mesophotic zone of Hawai‘i by Cabrera, Feresa P., Paiano, Monica O., Fumo, James T., Allsopp, Kazumi R., Smith, Celia M., Spalding, Heather L., Kosaki, Randall K., Sherwood, Alison R.

“…Over the last 2 decades, routine collections in the Hawaiian Archipelago have expanded to mesophotic reefs, leading to the discovery of a new red algal genus…”
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The telomere hypothesis of cellular aging by Harley, C B, Vaziri, H, Counter, C M, Allsopp, R C

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Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells by Allsopp, R C, Cheshier, S, Weissman, I L

“…Reactivation of telomerase and maintenance of telomere length can lead to the prevention of replicative senescence in some human somatic cells grown in vitro…”
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Evidence for a Critical Telomere Length in Senescent Human Fibroblasts by Allsopp, Richard C., Harley, Calvin B.

“…Telomeres, the G/C-rich DNA sequences capping the ends of all eukaryotic chromosomes, have been shown to shorten during replicative aging of normal cells in…”
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ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase by Vaziri, Homayoun, West, Michael D., Allsopp, Richard C., Davison, Timothy S., Wu, Yu-Sung, Arrowsmith, Cheryl H., Poirier, Guy G., Benchimol, Samuel

“…Telomere loss has been proposed as a mechanism for counting cell divisions during aging in normal somatic cells. How such a mitotic clock initiates the…”
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Telomere Shortening Is Associated with Cell Division in Vitro and in Vivo by Allsopp, Richard C., Chang, Edwin, Kashefi-Aazam, Mohammad, Rogaev, Evgeny I., Piatyszek, Mieczyslaw A., Shay, Jerry W., Harley, Calvin B.

“…In humans, the amount of terminal (TTAGGG)n, telomeric DNA decreases during aging of various somatic cell types in vitro and in vivo. While the factors…”
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In Situ Analysis of Changes in Telomere Size during Replicative Aging and Cell Transformation by Henderson, Scott, Allsopp, Richard, Spector, David, Wang, Sy-Shi, Harley, Calvin

“…Telomeres have been shown to gradually shorten during replicative aging in human somatic cells by Southern analysis. This study examines telomere shortening at…”
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