Search Results - "Allport, Jennifer R."

Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle by Kelly, Kimberly A, Allport, Jennifer R, Tsourkas, Andrew, Shinde-Patil, Vivek R, Josephson, Lee, Weissleder, Ralph

“…Endothelial vascular adhesion molecule-1 (VCAM-1) is a critical component of the leukocyte–endothelial adhesion cascade, and its strict temporal and spatial…”
Get full text

Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarction by JIQIU CHEN, TUNG, Ching-Hsuan, ALLPORT, Jennifer R, SI CHEN, WEISSLEDER, Ralph, HUANG, Paul L

“…We used a molecular probe activated by protease cleavage to image expression of matrix metalloproteinases (MMPs) in the heart after myocardial infarction. We…”
Get full text

Noninvasive In Vivo Imaging of Monocyte Trafficking to Atherosclerotic Lesions by KIRCHER, Moritz F, GRIMM, Jan, SWIRSKI, Filip K, LIBBY, Peter, GERSZTEN, Robert E, ALLPORT, Jennifer R, WEISSLEDER, Ralph

“…Monocytes play a key role in atherogenesis, but their participation has been discerned largely via ex vivo analyses of atherosclerotic lesions. We sought to…”
Get full text

Monocytes Induce Reversible Focal Changes in Vascular Endothelial Cadherin Complex during Transendothelial Migration under Flow by Allport, Jennifer R., Muller, William A., Luscinskas, Francis W.

“…The vascular endothelial cell cadherin complex (VE-cadherin, α-, β-, and γ-catenin, and p120/p100) localizes to adherens junctions surrounding vascular…”
Get full text

SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration by Kelly, Kimberly A., Allport, Jennifer R., Yu, Amy M., Sinh, Sumita, Sage, E. Helene, Gerszten, Robert E., Weissleder, Ralph

“…VCAM‐1 is a cell surface molecule, which has been shown to mediate leukocyte adhesion to the endothelium and subsequent transmigration. Although VCAM‐1…”
Get full text

Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro by Allport, Jennifer R., Lim, Yaw‐Chyn, Shipley, J. Michael, Senior, Robert M., Shapiro, Steven D., Matsuyoshi, Norihisa, Vestweber, Dietmar, Luscinskas, Francis W.

“…Recent evidence has suggested a role for neutrophil proteases during certain inflammatory responses. We demonstrated previously that neutrophil proteases can…”
Get full text

Murine Lewis Lung Carcinoma-Derived Endothelium Expresses Markers of Endothelial Activation and Requires Tumor-Specific Extracellular Matrix In Vitro by Allport, Jennifer R., Weissleder, Ralph

“…The purpose of the study was to identify characteristics specific to tumor-derived endothelium that may be important in tumor biology, or for the development…”
Get full text

Bone Marrow-Derived lin−c-kit+Sca-1+ Stem Cells Do Not Contribute to Vasculogenesis in Lewis Lung Carcinoma by Shinde Patil, Vivek R., Friedrich, Erik B., Wolley, Allison E., Gerszten, Robert E., Allport, Jennifer R., Weissleder, Ralph

“…The development of tumor vasculature is thought to occur through two complementary processes: sprouting angiogenesis from preexisting blood vessels of the…”
Get full text

In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors by KIRCHER, Moritz F, ALLPORT, Jennifer R, GRAVES, Edward E, LOVE, Victoria, JOSEPHSON, Lee, LICHTMAN, Andrew H, WEISSLEDER, Ralph

“…Magnetic resonance imaging (MRI) allows noninvasive and three-dimensional visualization of whole organisms over time, and, therefore, would be ideally suited…”
Get full text

In Vivo Imaging of Activated Endothelium Using an Anti-VCAM-1 Magnetooptical Probe by Tsourkas, Andrew, Shinde-Patil, Vivek R, Kelly, Kimberly A, Patel, Pratik, Wolley, Allison, Allport, Jennifer R, Weissleder, Ralph

“…It has been suggested that vascular cell adhesion molecule-1 (VCAM-1) could serve as an early marker for inflammation of the endothelium. The ability to…”
Get full text

In vivo imaging of gene and cell therapies by Allport, Jennifer R, Weissleder, Ralph

“…Molecular imaging can be broadly defined as the in vivo characterization and measurement of biological processes at the cellular and molecular level. In…”
Get full text

Heterogeneity of Endothelial Cells from Different Organ Sites in T-Cell Subset Recruitment by Lim, Yaw-Chyn, Garcia-Cardena, Guillermo, Allport, Jennifer R., Zervoglos, Mandy, Connolly, Andrew J., Gimbrone, Michael A., Luscinskas, Francis W.

“…Chemokines and adhesion molecules play a critical role in the recruitment of leukocytes into specific organ sites. Little is known, however, regarding the…”
Get full text

Integrin-Mediated Neutrophil Adhesion and Retinal Leukostasis in Diabetes by Barouch, Fina Canas, Miyamoto, Kazuaki, Allport, Jennifer R, Fujita, Kenji, Bursell, Sven-Erik, Aiello, Lloyd Paul, Luscinskas, Francis William, Adamis, Anthony P

“…A critical early event in the pathogenesis of diabetic retinopathy is leukocyte adhesion to the diabetic retinal vasculature. The process is mediated, in part,…”
Get full text

Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions by Allport, J R, Ding, H, Collins, T, Gerritsen, M E, Luscinskas, F W

“…Although several adhesion molecules expressed on leukocytes (beta1 and beta2 integrins, platelet endothelial cell adhesion molecule 1 [PECAM-1], and CD47) and…”
Get full text

Murine neuronal progenitor cells are preferentially recruited to tumor vasculature via a4-integrin and SDF-1a dependent mechanisms by Allport, Jennifer R., Patil, Vivek R. Shinde, Weissleder, Ralph

“…Recent studies have described neuronal progenitor cell recruitment to tumors in vivo, however, the mechanisms mediating this recruitment are not yet…”
Get full text

CD11b/CD18-coated microspheres attach to E-selectin under flow by Crutchfield, Karen L., Patil, Vivek R. Shinde, Campbell, Craig J., Parkos, Charles A., Allport, Jennifer R., Goetz, Douglas J.

“…Neutrophils can attach to E‐selectin under flow. Proposed ligands for E‐selectin carry SLex‐type glycans. The leukocyte β2 integrins are glycosylated with…”
Get full text

Reduction by inhibitors of mono(ADP‐ribosyl)transferase of chemotaxis in human neutrophil leucocytes by inhibition of the assembly of filamentous actin by Allport, Jennifer R., Donnelly, Louise E., Hayes, Brian P., Murray, Stephen, Rendell, Nigel B., Ray, Keith P., MacDermot, John

“…1 Chemotaxis of human neutrophils is mediated by numerous agents [e.g. N‐formyl‐methionyl‐leucyl‐phenylalanine (FMLP) and platelet activating factor (PAF)]…”
Get full text

Murine Lewis Lung Carcinoma-Derived Endothelium Expresses Markers of Endothelial Activation and Requires Tumor-Specific Extracellular Matrix In Vitro1 by Allport, Jennifer R, Weissleder, Ralph

“…The purpose of the study was to identify characteristics specific to tumor-derived endothelium that may be important in tumor biology, or for the development…”
Get full text

Near-infrared fluorescent imaging of matrix metalloproteinase activity following myocardial infarction by Chen, Jiqiu, Tung, Ching-Hsuan, Allport, Jennifer R., Chen, Si, Weissleder, Ralph, Huang, Paul L.

“…We used a molecular probe activated by protease cleavage to image expression of matrix metalloproteinases (MMPs) in the heart following myocardial infarction…”
Get full text

Murine neuronal progenitor cells are preferentially recruited to tumor vasculature via alpha4-integrin and SDF-1alpha-dependent mechanisms by Allport, Jennifer R, Shinde Patil, Vivek R, Weissleder, Ralph

“…Recent studies have described neuronal progenitor cell recruitment to tumors in vivo, however, the mechanisms mediating this recruitment are not yet…”
Get full text