Search Results - "Alloza, I"
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The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis
Published in Genes and immunity (01-07-2010)“…Genome-wide association studies (GWAS) have revealed that different diseases share susceptibility variants. Twelve single-nucleotide polymorphisms (SNPs)…”
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ANKRD55 and DHCR7 are novel multiple sclerosis risk loci
Published in Genes and immunity (01-04-2012)“…Multiple sclerosis (MS) shares some risk genes with other disorders hallmarked by an autoimmune pathogenesis, most notably IL2RA and CLEC16A . We analyzed 10…”
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Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection
Published in Genes and immunity (01-01-2011)“…In recent reports, IRF5 polymorphisms showed significant association with multiple sclerosis (MS) susceptibility in three studied populations and Irf5…”
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Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis
Published in Journal of neuroimmunology (01-04-2012)“…Abstract Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10…”
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Replication of top markers of a genome-wide association study in multiple sclerosis in Spain
Published in Genes and immunity (01-03-2011)“…Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system with presumed autoimmune origin, triggered by genetic and environmental…”
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The CTLA4 +49 A/GG-CT60G haplotype is associated with susceptibility to multiple sclerosis in Flanders
Published in Journal of neuroimmunology (01-07-2005)“…Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system white matter characterized by inflammation, demyelination and axonal…”
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A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis
Published in Genes and immunity (01-01-2012)“…Cytokine and cytokine receptor genes, including IL2RA , IL7R and IL12A , are known risk factors for multiple sclerosis (MS). Excitotoxic oligodendroglial death…”
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The metallopeptide antibiotic bacitracin inhibits interleukin-12 αβ and β2 secretion
Published in Journal of pharmacy and pharmacology (01-02-2005)“…The metalloantibiotic bacitracin is a known inhibitor of protein disulfide isomerase (PDI). The disulfide‐linked interleukin‐12 (IL‐12) αβ‐heterodimer and…”
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Inhibiting cytokines of the interleukin-12 family: recent advances and novel challenges
Published in Journal of pharmacy and pharmacology (01-02-2004)“…ABSTRACT Interleukin‐12 (IL‐12) and the more recently discovered IL‐23 and IL‐27 constitute a unique family of structurally related, heterodimeric cytokines…”
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Polymorphisms in the interleukin-4 and IL-4 receptor genes and multiple sclerosis: a study in Spanish-Basque, Northern Irish and Belgian populations
Published in International journal of immunogenetics (01-12-2005)“…Summary Cytokine gene polymorphisms are known to influence susceptibility and disease course of many autoimmune diseases. Multiple sclerosis (MS) is a chronic…”
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IL7RA polymorphisms and chronic inflammatory arthropathies
Published in Tissue antigens (01-11-2009)“…The C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin‐7 receptor alpha chain (IL7RA) was recently found to be…”
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Atlas VPM: two decades informing on unwarranted variations in health care in Spain
Published in Research in Health Services & Regions (20-07-2022)“…Since the early 2000's, the Atlas of Variations in Medical Practice in the Spanish National Health System (namely, Atlas VPM) has been analysing and informing…”
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The metallopeptide antibiotic bacitracin inhibits interleukin-12 alphabeta and beta2 secretion
Published in Journal of pharmacy and pharmacology (01-02-2005)“…The metalloantibiotic bacitracin is a known inhibitor of protein disulfide isomerase (PDI). The disulfide-linked interleukin-12 (IL-12) alphabeta-heterodimer…”
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Confirmation of Human Endogenous Retrovirus HERV-Fc1 role in multiple sclerosis risk
Published in Frontiers in immunology (2013)“…Abstract only…”
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Polymorphisms in the interferon‐γ/interleukin‐26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis
Published in Arthritis and rheumatism (01-10-2003)“…Objective To determine whether polymorphisms in the interferon‐γ (IFNγ)/interleukin‐26 (IL‐26; formerly, AK155) gene cluster contribute to sex‐based…”
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IFNG polymorphisms are associated with gender differences in susceptibility to multiple sclerosis
Published in Genes and immunity (01-03-2005)“…Interferon-gamma (IFNgamma) treatment is deleterious in multiple sclerosis (MS). MS occurs twice as frequently in women as in men. IFNgamma expression varies…”
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The CTLA4 + 49 A/G G– CT60 G haplotype is associated with susceptibility to multiple sclerosis in Flanders
Published in Journal of neuroimmunology (2005)“…Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system white matter characterized by inflammation, demyelination and axonal…”
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The Conserved Helix C Region in the Superfamily of Interferon-γ/Interleukin-10-related Cytokines Corresponds to a High-affinity Binding Site for the HSP70 Chaperone DnaK
Published in The Journal of biological chemistry (12-07-2002)“…HSP70 chaperones mediate protein folding by ATP-dependent interaction with short linear peptide segments that are exposed on unfolded proteins. The mode of…”
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Interleukin-12 p40 polymorphism and susceptibility to multiple sclerosis
Published in Annals of neurology (01-10-2002)Get full text
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