Search Results - "Allodi, I"

Motor neurons with differential vulnerability to degeneration show distinct protein signatures in health and ALS by Comley, L, Allodi, I, Nichterwitz, S, Nizzardo, M, Simone, C, Corti, S, Hedlund, E

“…Highlights • The motor protein dynein is down-regulated in resistant and vulnerable motor neurons (MNs) in ALS. • The high level of Gabra1 in oculomotor MNs in…”
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Synaptotagmin 13 is neuroprotective across motor neuron diseases by Nizzardo, M., Taiana, M., Rizzo, F., Aguila Benitez, J., Nijssen, J., Allodi, I., Melzi, V., Bresolin, N., Comi, G. P., Hedlund, E., Corti, S.

“…In amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), spinal and lower brainstem motor neurons degenerate, but some motor neuron subtypes…”
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Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons by Allodi, Ilary, Montañana-Rosell, Roser, Selvan, Raghavendra, Löw, Peter, Kiehn, Ole

“…ALS is characterized by progressive inability to execute movements. Motor neurons innervating fast-twitch muscle-fibers preferentially degenerate. The reason…”
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LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy by Nichterwitz, Susanne, Nijssen, Jik, Storvall, Helena, Schweingruber, Christoph, Comley, Laura Helen, Allodi, Ilary, Lee, Mirjam van der, Deng, Qiaolin, Sandberg, Rickard, Hedlund, Eva

“…Somatic motor neurons are selectively vulnerable in spinal muscular atrophy (SMA), which is caused by a deficiency of the ubiquitously expressed survival of…”
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Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS by Allodi, Ilary, Comley, Laura, Nichterwitz, Susanne, Nizzardo, Monica, Simone, Chiara, Benitez, Julio Aguila, Cao, Ming, Corti, Stefania, Hedlund, Eva

“…The fatal disease amyotrophic lateral sclerosis (ALS) is characterized by the loss of somatic motor neurons leading to muscle wasting and paralysis. However,…”
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Intact single muscle fibres from SOD1G93A amyotrophic lateral sclerosis mice display preserved specific force, fatigue resistance and training‐like adaptations by Cheng, Arthur J., Allodi, Ilary, Chaillou, Thomas, Schlittler, Maja, Ivarsson, Niklas, Lanner, Johanna T., Thams, Sebastian, Hedlund, Eva, Andersson, Daniel C.

“…Key points How defects in muscle contractile function contribute to weakness in amyotrophic lateral sclerosis (ALS) were systematically investigated. Weakness…”
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Modeling Motor Neuron Resilience in ALS Using Stem Cells by Allodi, Ilary, Nijssen, Jik, Benitez, Julio Aguila, Schweingruber, Christoph, Fuchs, Andrea, Bonvicini, Gillian, Cao, Ming, Kiehn, Ole, Hedlund, Eva

“…Oculomotor neurons, which regulate eye movement, are resilient to degeneration in the lethal motor neuron disease amyotrophic lateral sclerosis (ALS). It would…”
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Directed midbrain and spinal cord neurogenesis from pluripotent stem cells to model development and disease in a dish by Allodi, Ilary, Hedlund, Eva

“…Induction of specific neuronal fates is restricted in time and space in the developing CNS through integration of extrinsic morphogen signals and intrinsic…”
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Intact single muscle fibres from SOD1 G93A amyotrophic lateral sclerosis mice display preserved specific force, fatigue resistance and training-like adaptations by Cheng, Arthur J, Allodi, Ilary, Chaillou, Thomas, Schlittler, Maja, Ivarsson, Niklas, Lanner, Johanna T, Thams, Sebastian, Hedlund, Eva, Andersson, Daniel C

“…How defects in muscle contractile function contribute to weakness in amyotrophic lateral sclerosis (ALS) were systematically investigated. Weakness in whole…”
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Increased fatigue resistance and preserved specific force in intact single muscle fibres from the SOD1G93A mouse model of ALS by Cheng, A, Allodi, I, Chaillou, Thomas, Thams, S, Ivarsson, N, Schlittler, M, Lanner, J, Hedlund, E, Andersson, D

“…Introduction : Amyotrophic lateral sclerosis (ALS) is a motor neurone disease characterized by degeneration and loss of motor neurones, leading to severe…”
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The oculomotor restricted protein synaptotagmin 13 protects motor neurons from degeneration in ALS and SMA (P3.131) by Nizzardo, Monica, Rizzo, Federica, Taiana, Michela, Allodi, Ilary, Benitez, Julio Aguila, Nijssen, Jik, Ulzi, Gianna, Melzi, Valentina, Del Bo, Roberto, Bresolin, Nereo, Comi, Giacomo, Hedlund, Eva, Corti, Stefania

“…Abstract only…”
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Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation by Mills, Richard, Taylor-Weiner, Hermes, Correia, Jorge C, Agudelo, Leandro Z, Allodi, Ilary, Kolonelou, Christina, Martinez-Redondo, Vicente, Ferreira, Duarte M S, Nichterwitz, Susanne, Comley, Laura H, Lundin, Vanessa, Hedlund, Eva, Ruas, Jorge L, Teixeira, Ana I

“…We examined whether skeletal muscle overexpression of PGC-1α1 or PGC-1α4 affected myokine secretion and neuromuscular junction (NMJ) formation. A microfluidic…”
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