Search Results - "Allnutt, Mary Alice"
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Stabilization and Reduced Cytotoxicity of Amyloid Beta Aggregates in the Presence of Catechol Neurotransmitters
Published in Neurochemical research (01-02-2024)“…Oligomeric aggregates of the amyloid-beta (Aβ) peptide have been implicated as the toxic species for Alzheimer’s disease by contributing to oxidative…”
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Human Herpesvirus 6 Detection in Alzheimer’s Disease Cases and Controls across Multiple Cohorts
Published in Neuron (Cambridge, Mass.) (18-03-2020)“…The interplay between viral infection and Alzheimer’s disease (AD) has long been an area of interest, but proving causality has been elusive. Several recent…”
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Do herpesviruses play a role in Alzheimer’s disease pathogenesis?
Published in Drug discovery today. Disease models (2020)“…Recent studies have brought renewed interest to the hypothesis that infection plays a role in the pathogenesis of Alzheimer’s disease (AD). In particular,…”
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Decoding transcriptomic signatures of cysteine string protein alpha-mediated synapse maintenance
Published in Proceedings of the National Academy of Sciences - PNAS (11-06-2024)“…Synapse maintenance is essential for generating functional circuitry, and decrement in this process is a hallmark of neurodegenerative disease. Yet, little is…”
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Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q
Published in Science translational medicine (01-06-2022)“…Microglia-mediated synaptic loss contributes to the development of cognitive impairments in Alzheimer's disease (AD). However, the basis for this…”
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