Search Results - "Allison Pledgie"
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1
Sulforaphane induces cell type–specific apoptosis in human breast cancer cell lines
Published in Molecular cancer therapeutics (01-03-2007)“…Sulforaphane, an isothiocyanate found in cruciferous vegetables, has been shown to induce phase 2 detoxication enzymes and inhibit the growth of chemically…”
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Journal Article -
2
Molecular mechanisms of polyamine analogs in cancer cells
Published in Anti-cancer drugs (01-03-2005)“…The natural polyamines are aliphatic cations with multiple functions and are essential for cell growth. Soon after the critical requirement of polyamines for…”
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3
Spermine Oxidase SMO(PAOh1), Not N1-Acetylpolyamine Oxidase PAO, Is the Primary Source of Cytotoxic H2O2 in Polyamine Analogue-treated Human Breast Cancer Cell Lines
Published in The Journal of biological chemistry (02-12-2005)“…The induction of polyamine catabolism and its production of H2O2 have been implicated in the response to specific antitumor polyamine analogues. The original…”
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4
Role of p53/p21Waf1/Cip1 in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells
Published in Cancer biology & therapy (01-09-2005)“…Intracellular polyamines are absolutely required for cell proliferation and many tumors have abnormal requirements for polyamines. Therefore, the polyamine…”
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5
Polyamine Analogues Down-regulate Estrogen Receptor α Expression in Human Breast Cancer Cells
Published in The Journal of biological chemistry (14-07-2006)“…The critical role of polyamines in cell growth has led to the development of a number of agents that interfere with polyamine metabolism including a novel…”
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6
Polyamine Analogues Down-regulate Estrogen Receptor α Expression in Human Breast Cancer Cells
Published in The Journal of biological chemistry (14-07-2006)“…The critical role of polyamines in cell growth has led to the development of a number of agents that interfere with polyamine metabolism including a novel…”
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Journal Article -
7
Role of p53/p21(Waf1/Cip1) in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells
Published in Cancer biology & therapy (01-09-2005)“…Intracellular polyamines are absolutely required for cell proliferation and many tumors have abnormal requirements for polyamines. Therefore, the polyamine…”
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Journal Article -
8
Role of p53/p21 Waf1/Cip1 in the Regulation of Polyamine Analogue-Induced Growth Inhibition and Cell Death in Human Breast Cancer Cells
Published in Cancer biology & therapy (01-09-2005)“…Intracellular polyamines are absolutely required for cell proliferation and many tumors have abnormal requirements for polyamines. Therefore, the polyamine…”
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Journal Article -
9
The molecular pathways of polyamine catabolism in human breast cancer cell lines
Published 01-01-2006“…The natural polyamines are essential for normal cell growth and differentiation. Breast cancer contains higher intracellular levels of the natural polyamines…”
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Dissertation
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10
role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines
Published in Cancer chemotherapy and pharmacology (01-05-2010)“…Introduction Polyamine analogues have demonstrated significant activity against human breast cancer cell lines as single agents as well as in combination with…”
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11
The molecular pathways of polyamine catabolism in human breast cancer cell lines
“…The natural polyamines are essential for normal cell growth and differentiation. Breast cancer contains higher intracellular levels of the natural polyamines…”
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Dissertation