Search Results - "Alli, A."

Extracellular Vesicles: Investigating the Pathophysiology of Diabetes-Associated Hypertension and Diabetic Nephropathy by Alli, Abdel A

“…Extracellular vesicles (EVs) include exosomes, microvesicles, and apoptotic bodies. EVs are released by all cell types and are found in biological fluids…”
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Lipidomic and proteomic analysis of exosomes from mouse cortical collecting duct cells by Dang, Viet D., Jella, Kishore Kumar, Ragheb, Ragy R. T., Denslow, Nancy D., Alli, Abdel A.

“…ABSTRACT Exosomes are endosome‐derived nanovesicles that are involved in cellular communication and signaling. Exosomes are produced by epithelial cells and…”
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Cathepsin B Is Secreted Apically from Xenopus 2F3 Cells and Cleaves the Epithelial Sodium Channel (ENaC) to Increase Its Activity by Alli, Abdel A., Song, John Z., Al-Khalili, Otor, Bao, Hui-Fang, Ma, He-Ping, Alli, Alia A., Eaton, Douglas C.

“…The epithelial sodium channel (ENaC) plays an important role in regulating sodium balance, extracellular volume, and blood pressure. Evidence suggests the α…”
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Exosomal GAPDH from Proximal Tubule Cells Regulate ENaC Activity by Jella, Kishore Kumar, Yu, Ling, Yue, Qiang, Friedman, Daniel, Duke, Billie J, Alli, Abdel A

“…Exosomes are nanometer-scale, cell-derived vesicles that contain various molecules including nucleic acids, proteins, and lipids. These vesicles can release…”
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Augmentation of Cathepsin Isoforms in Diabetic db/db Mouse Kidneys Is Associated with an Increase in Renal MARCKS Expression and Proteolysis by Gholam, Mohammed F, Bala, Niharika, Dogan, Yunus E, Alli, Abdel A

“…The expression of the myristoylated alanine-rich C-kinase substrate (MARCKS) family of proteins in the kidneys plays an important role in the regulation of the…”
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Lipid Profiles of Urinary Extracellular Vesicles Released during the Inactive and Active Phases of Aged Male Mice with Spontaneous Hypertension by Lopez, Juliana Pena, Nouri, Mohammad-Zaman, Ebrahim, Areej, Chacko, Kevin M, Schramm, Whitney C, Gholam, Mohammed F, Ozrazgat-Baslanti, Tezcan, Denslow, Nancy D, Alli, Abdel A

“…Hypertension remains a major problem, especially in the elderly, as it increases the risk for cardiovascular, coronary artery, cerebrovascular, and kidney…”
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Dapagliflozin Treatment Augments Bioactive Phosphatidylethanolamine Concentrations in Kidney Cortex Membrane Fractions of Hypertensive Diabetic db/db Mice and Alters the Density of Lipid Rafts in Mouse Proximal Tubule Cells by Gholam, Mohammed F, Liu, Lauren P, Searcy, Louis A, Denslow, Nancy D, Alli, Abdel A

“…In addition to inhibiting renal glucose reabsorption and allowing for glucose excretion, the sodium/glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin may…”
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COVID-19 Plasma Extracellular Vesicles Increase the Density of Lipid Rafts in Human Small Airway Epithelial Cells by Darwish, Sara, Liu, Lauren P, Robinson, Tanya O, Tarugu, Spurthi, Owings, Anna H, Glover, Sarah C, Alli, Abdel A

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the causative agent of the COVID-19 disease. COVID-19 viral infection can affect many…”
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Melatonin salvages lead‐induced neuro‐cognitive shutdown, anxiety, and depressive‐like symptoms via oxido‐inflammatory and cholinergic mechanisms by Omeiza, Noah A., Abdulrahim, Halimat A., Alagbonsi, Abdullateef I., Ezurike, Precious U., Soluoku, Talha K., Isiabor, Happy, Alli‐oluwafuyi, Abdulmusawwir A.

“…Introduction Lead is the most used nonphysiological neurotoxic heavy metal in the world that has been indicated to interfere with the cognitive and…”
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C Type Natriuretic Peptide Receptor Activation Inhibits Sodium Channel Activity in Human Aortic Endothelial Cells by Activating the Diacylglycerol-Protein Kinase C Pathway by Yu, Ling, Nouri, Mohammad-Zaman, Liu, Lauren P, Bala, Niharika, Denslow, Nancy D, LaDisa, Jr, John F, Alli, Abdel A

“…The C-type natriuretic peptide receptor (NPRC) is expressed in many cell types and binds all natriuretic peptides with high affinity. Ligand binding results in…”
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A computing method‐based rearrangement of network protocols to improvise quality factors of FACTS devices and sensors using Newton‐Raphson technique by Sundaravazhuthi, V., Alli Rani, A., Manoj Kumar, M.

“…The load flow analysis project was carried out using the Newton‐Raphson's iteration technique and a multiobjective method was suggested to minimize power loss,…”
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High levels of multidrug resistance in clinical isolates of Gram-negative pathogens from Nigeria by Ogbolu, D.O, Daini, O.A, Ogunledun, A, Alli, A.O, Webber, M.A

“…Abstract In Nigeria, quinolones and β-lactam antibiotics are widely used to treat bacterial infections. This study aimed to identify the prevalence of…”
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ENaC is regulated by natriuretic peptide receptor-dependent cGMP signaling by Guo, Lai-Jing, Alli, Abdel A, Eaton, Douglas C, Bao, Hui-Fang

“…Epithelial sodium channels (ENaCs) located at the apical membrane of polarized epithelial cells are regulated by the second messenger guanosine 3',5'-cyclic…”
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Phosphatidylinositol phosphate-dependent regulation of Xenopus ENaC by MARCKS protein by Alli, Abdel A, Bao, Hui-Fang, Alli, Alia A, Aldrugh, Yasir, Song, John Z, Ma, He-Ping, Yu, Ling, Al-Khalili, Otor, Eaton, Douglas C

“…Phosphatidylinositol phosphates (PIPs) are known to regulate epithelial sodium channels (ENaC). Lipid binding assays and coimmunoprecipitation showed that the…”
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Phytomedicine in Disease Management: In-Silico Analysis of the Binding Affinity of Artesunate and Azadirachtin for Malaria Treatment by Okoh, Michael P, Singla, Rajeev K, Madu, Chijioke, Soremekun, Opeyemi, Adejoh, Johnson, Alli, Lukman A, Shen, Bairong

“…In the rural communities of sub-Saharan African (sSA) countries, malaria is being managed using phytocompounds. Artesunate is reported to inhibit Gephyrin E, a…”
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Development and validation of an instrument for procedure-related death notification by Keyes, C., Alli, A., Orr, F.K.

“…Background. Anaesthesia-related mortality is an important, potentially avoidable cause of perioperative mortality. A procedure-related death notification…”
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Human Alpha-1 Antitrypsin Attenuates ENaC and MARCKS and Lowers Blood Pressure in Hypertensive Diabetic db/db Mice by Lugo, Carlos I, Liu, Lauren P, Bala, Niharika, Morales, Angelica G, Gholam, Mohammed F, Abchee, Julia C, Elmoujahid, Nasseem, Elshikha, Ahmed Samir, Avdiaj, Rigena, Searcy, Louis A, Denslow, Nancy D, Song, Sihong, Alli, Abdel A

“…Hypertension may develop before or after the onset of diabetes and it is known to increase the risk of developing diabetic nephropathy. Alpha-1 antitrypsin…”
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Tempol Alters Urinary Extracellular Vesicle Lipid Content and Release While Reducing Blood Pressure during the Development of Salt-Sensitive Hypertension by Chacko, Kevin M, Nouri, Mohammad-Zaman, Schramm, Whitney C, Malik, Zeeshan, Liu, Lauren P, Denslow, Nancy D, Alli, Abdel A

“…Salt-sensitive hypertension resulting from an increase in blood pressure after high dietary salt intake is associated with an increase in the production of…”
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Transgenic Mice Overexpressing Human Alpha-1 Antitrypsin Exhibit Low Blood Pressure and Altered Epithelial Transport Mechanisms in the Inactive and Active Cycles by Liu, Lauren P, Gholam, Mohammed F, Elshikha, Ahmed Samir, Kawakibi, Tamim, Elmoujahid, Nasseem, Moussa, Hassan H, Song, Sihong, Alli, Abdel A

“…Human alpha-1 antitrypsin (hAAT) is a versatile protease inhibitor, but little is known about its targets in the aldosterone-sensitive distal nephron and its…”
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Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction by Czikora, Istvan, Alli, Abdel A, Sridhar, Supriya, Matthay, Michael A, Pillich, Helena, Hudel, Martina, Berisha, Besim, Gorshkov, Boris, Romero, Maritza J, Gonzales, Joyce, Wu, Guangyu, Huo, Yuqing, Su, Yunchao, Verin, Alexander D, Fulton, David, Chakraborty, Trinad, Eaton, Douglas C, Lucas, Rudolf

“…is a major etiologic agent of bacterial pneumonia. Autolysis and antibiotic-mediated lysis of pneumococci induce release of the pore-forming toxin, pneumolysin…”
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