Markers for Nodal Metastasis in Head and Neck Squamous Cell Cancer

OBJECTIVE To identify markers that are relevant as predictors of lymph node metastasis in head and neck squamous cell cancer. DESIGN Expression of p53, Rb, cyclin D1, E-cadherin, and epithelial cell adhesion molecule was examined using immunohistochemical analysis and traditional histological parame...

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Published in:	Archives of otolaryngology, head & neck surgery Vol. 128; no. 5; pp. 512 - 518
Main Authors:	Takes, Robert P, Baatenburg de Jong, Robert J, Alles, Martijn J. R. C, Meeuwis, Cees A, Marres, Henri A. M, Knegt, Paul P. M, de la Riviere, Guy Brutel, de Wilde, Peter C. M, Mooi, Wolter J, Hermans, Jo, van Krieken, J. Han J. M
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Chicago, IL American Medical Association 01-05-2002
Subjects:	Adult Aged Aged, 80 and over Antigens, Neoplasm - metabolism Biological and medical sciences Biomarkers, Tumor - metabolism Cadherins - metabolism Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Adhesion Molecules - metabolism Cyclin D1 - metabolism Epithelial Cell Adhesion Molecule Female Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Host-tumor relations. Immunology. Biological markers Humans Lymphatic Metastasis Male Medical sciences Middle Aged Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Retinoblastoma Protein - metabolism Sensitivity and Specificity Tumor Suppressor Protein p53 - metabolism Tumors Performance evaluation Immunohistochemistry p53 Protein Malignant lymphadenopathy Tumoral marker Metastasis Cyclin D1 Histopathology Histological type Head and neck ENT disease Lymphatic dissemination Pharynx disease Larynx Larynx disease E Cadherin Human Squamous cell carcinoma Lymph node Stomatology Cell adhesion molecule Retinoblastoma protein Exploration Malignant tumor Pharynx Pathology Oral cavity Epithelial cell Oral cavity disease Comparative study
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Summary:	OBJECTIVE To identify markers that are relevant as predictors of lymph node metastasis in head and neck squamous cell cancer. DESIGN Expression of p53, Rb, cyclin D1, E-cadherin, and epithelial cell adhesion molecule was examined using immunohistochemical analysis and traditional histological parameters, and the correlation of these markers with the histologically verified presence of regional metastases was determined. SUBJECTS The study sample comprised 121 patients with head and neck squamous cell cancer from whom paraffin-embedded material of primary tumors was used. RESULTS Lymph node metastasis was correlated with the loss of expression of Rb (P = .04) and marginally correlated with the loss of expression of E-cadherin (P = .06). If the results are broken down to subsites, loss of E-cadherin expression in oral cancer (P = .04) and absence of eosinophilic infiltration in laryngeal cancer (P = .003) correlated with nodal metastasis. None of the other markers correlated. A combination of relevant parameters did not result in a much stronger correlation. CONCLUSIONS The expression of the investigated genetic markers and histopathological features of primary tumors can supply limited information on the metastatic behavior of tumors. Although the use of markers for regional metastasis would be a welcome additional tool, these results do not warrant the use of these parameters for clinical decision making concerning the treatment of the neck in patients with head and neck squamous cell cancer.Arch Otolaryngol Head Neck Surg. 2002;128:512-518-->
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0886-4470 2168-6181 1538-361X 2168-619X
DOI:	10.1001/archotol.128.5.512