Search Results - "Allert, Malin"

Discovery of Thermostable, Fluorescently Responsive Glucose Biosensors by Structure-Assisted Function Extrapolation by Allert, Malin J, Hellinga, Homme W

“…Accurate assignment of protein function from sequence remains a fascinating and difficult challenge. The periplasmic-binding protein (PBP) superfamily present…”
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Accurate Identification of Periplasmic Urea-binding Proteins by Structure- and Genome Context-assisted Functional Analysis by Allert, Malin J., Kumar, Shivesh, Wang, You, Beese, Lorena S., Hellinga, Homme W.

“…[Display omitted] •Bacterial urea metabolism is a key component in the global nitrogen cycle.•Identification of urea-binding proteins in ABC transporters is…”
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Describing Complex Structure-Function Relationships in Biomolecules at Equilibrium by Allert, Malin J., Hellinga, Homme W.

“…One of the great ambitions of structural biology is to describe structure-function relationships quantitatively. Statistical thermodynamics is a powerful,…”
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Harnessing Environmental Ca2+ for Extracellular Protein Thermostabilization by Allert, Malin J, Hellinga, Homme W

“…Ca2+ is the third-most prevalent metal ion in the environment. EF hands are common Ca2+-binding motifs found in both extracellular and intracellular proteins…”
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Harnessing Environmental Ca 2+ for Extracellular Protein Thermostabilization by Allert, Malin J, Hellinga, Homme W

“…Ca is the third-most prevalent metal ion in the environment. EF hands are common Ca -binding motifs found in both extracellular and intracellular proteins of…”
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Chromophore carbonyl twisting in fluorescent biosensors encodes direct readout of protein conformations with multicolor switching by Allert, Malin J., Kumar, Shivesh, Wang, You, Beese, Lorena S., Hellinga, Homme W.

“…Fluorescent labeling of proteins is a powerful tool for probing structure-function relationships with many biosensing applications. Structure-based rules for…”
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Multifactorial Determinants of Protein Expression in Prokaryotic Open Reading Frames by Allert, Malin, Cox, J. Colin, Hellinga, Homme W.

“…A quantitative description of the relationship between protein expression levels and open reading frame (ORF) nucleotide sequences is important for…”
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Computational Design of Receptors for an Organophosphate Surrogate of the Nerve Agent Soman by Allert, Malin, Rizk, Shahir S., Looger, Loren L., Hellinga, Homme W., Wells, James A.

“…We report the computational design of soluble protein receptors for pinacolyl methyl phosphonic acid (PMPA), the predominant hydrolytic product of the nerve…”
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Retraction of “Local Encoding of Computationally Designed Enzyme Activity” [J. Mol. Biol. 366 (2007) 945–953] by Allert, Malin, Dwyer, Mary A., Hellinga, Homme W.

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Local encoding of computationally designed enzyme activity by Allert, Malin, Dwyer, Mary A, Hellinga, Homme W

“…One aim of computational protein design is to introduce novel enzyme activity into proteins of known structure by predicting mutations that stabilize…”
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Noncovalent Binding of a Reaction Intermediate by a Designed Helix-Loop-Helix Motif--Implications for Catalyst Design by Allert, Malin, Baltzer, Lars

“…In our search for a catalyst for the transamination reaction of aspartic acid to form oxaloacetate, twenty-five forty-two-residue sequences were designed to…”
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Setting the Stage for New Catalytic Functions in Designed Proteins-Exploring the Imine Pathway in the Efficient Decarboxylation of Oxaloacetate by an Arg-Lys Site in a Four-Helix Bundle Protein Scaffold by Allert, Malin, Baltzer, Lars

“…Fourteen 42‐residue polypeptides have been designed to identify reactive sites for the catalysis of the decarboxylation of oxaloacetate, a chemical…”
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The backbone structure of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein is essentially identical to its mesophilic E. coli homolog by Cuneo, Matthew J, Tian, Yaji, Allert, Malin, Hellinga, Homme W

“…Comparison of experimentally determined mesophilic and thermophilic homologous protein structures is an important tool for understanding the mechanisms that…”
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The backbone structure of the thermophilic Thermoanaerobacter tengcongensis ibose binding protein is essentially identical to its mesophilic E. coli homolog by Cuneo, Matthew J, Tian, Yaji, Allert, Malin, Hellinga, Homme W

“…Background Comparison of experimentally determined mesophilic and thermophilic homologous protein structures is an important tool for understanding the…”
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RETRACTED: Local Encoding of Computationally Designed Enzyme Activity by Allert, Malin, Dwyer, Mary A., Hellinga, Homme W.

“…This article has been retracted at the request of the authors and the Editor-in-Chief. Please see Elsevier Policy on Article Withdrawal…”
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