Search Results - "Allensworth, Melody L."

Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators by Allensworth‐James, Melody L., Odle, Angela K., Lim, Juchan, LaGasse, Alex N., Miles, Tiffany K., Hardy, Linda L., Haney, Anessa C., MacNicol, Melanie C., MacNicol, Angus M., Childs, Gwen V.

“…In normal individuals, pituitary somatotrophs optimise body composition by responding to metabolic signals from leptin. To identify mechanisms behind the…”
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410 Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge and Resistance in Male Offspring to a High Fat Diet by Miles, Tiffany K., Allensworth, Melody L., Silva Moreira, Ana Rita, Odle, Angela K., Haney, Anessa, Lagasse, Alexandra, MacNicol, Angus M., Childs, Gwen V.

“…OBJECTIVES/GOALS: Maternal undernutrition, a form of malnutrition, can alter neonatal leptin signaling and result in metabolic dysfunction in adulthood. We…”
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Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence by Odle, Angela K, Akhter, Noor, Syed, Mohsin M, Allensworth-James, Melody L, Beneš, Helen, Melgar Castillo, Andrea I, MacNicol, Melanie C, MacNicol, Angus M, Childs, Gwen V

“…The adipokine leptin signals the body's nutritional status to the brain, and particularly, the hypothalamus. However, leptin receptors (LEPRs) can be found all…”
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Selective Deletion of Leptin Receptors in Gonadotropes Reveals Activin and GnRH-Binding Sites as Leptin Targets in Support of Fertility by Akhter, Noor, CarlLee, Tyler, Syed, Mohsin M, Odle, Angela K, Cozart, Michael A, Haney, Anessa C, Allensworth-James, Melody L, Beneš, Helen, Childs, Gwen V

“…The adipokine, leptin (LEP), is a hormonal gateway, signaling energy stores to appetite-regulatory neurons, permitting reproduction when stores are sufficient…”
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Sex Differences in Somatotrope Dependency on Leptin Receptors in Young Mice: Ablation of LEPR Causes Severe Growth Hormone Deficiency and Abdominal Obesity in Males by Allensworth-James, Melody L, Odle, Angela, Haney, Anessa, Childs, Gwen

“…Leptin receptor (LEPR) signaling controls appetite and energy expenditure. Somatotrope-specific deletion of the LEPRb signaling isoform causes GH deficiency…”
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Sex-specific changes in postnatal GH and PRL secretion in somatotrope LEPR-null mice by Allensworth-James, Melody L, Odle, Angela, Haney, Anessa, MacNicol, Melanie, MacNicol, Angus, Childs, Gwen

“…The developing pituitary is a rapidly changing environment that is constantly meeting the physiological demands of the growing organism. During early postnatal…”
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Sex differences in somatotrope response to fasting: biphasic responses in male mice by Miles, Tiffany K, Silva Moreira, Ana Rita, Allensworth-James, Melody L, Odle, Angela K, Haney, Anessa C, MacNicol, Angus M, MacNicol, Melanie C, Childs, Gwen V

“…Anterior pituitary somatotropes are important metabolic sensors responding to leptin by secreting growth hormone (GH). However, reduced leptin signals caused…”
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A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones by Odle, Angela K, Allensworth-James, Melody L, Akhter, Noor, Syed, Mohsin, Haney, Anessa C, MacNicol, Melanie, MacNicol, Angus M, Childs, Gwen V

“…Pituitary somatotropes perform the key function of coordinating organismic growth and body composition with metabolic signals. However, the mechanism by which…”
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Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain by Miles, Tiffany K, Allensworth-James, Melody L, Odle, Angela K, Silva Moreira, Ana Rita, Haney, Anessa C, LaGasse, Alex N, Gies, Allen J, Byrum, Stephanie D, Riojas, Angelica M, MacNicol, Melanie C, MacNicol, Angus M, Childs, Gwen V

“…Maternal nutrition during embryonic development and lactation influences multiple aspects of offspring health. Using mice, this study investigates the effects…”
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Ablation of Leptin Signaling to Somatotropes: Changes in Metabolic Factors that Cause Obesity by Akhter, Noor, Odle, Angela K, Allensworth-James, Melody L, Haney, Anessa C, Syed, Mohsin M, Cozart, Michael A, Chua, Streamson, Kineman, Rhonda, Childs, Gwen V

“…Mice with somatotrope-specific deletion of the Janus kinase binding site in leptin receptors are GH deficient as young adults and become obese by 6 months of…”
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