Search Results - "Allende, Luis"

T-Helper Cell Subset Response Is a Determining Factor in COVID-19 Progression by Gil-Etayo, Francisco Javier, Suàrez-Fernández, Patricia, Cabrera-Marante, Oscar, Arroyo, Daniel, Garcinuño, Sara, Naranjo, Laura, Pleguezuelo, Daniel E, Allende, Luis M, Mancebo, Esther, Lalueza, Antonio, Díaz-Simón, Raquel, Paz-Artal, Estela, Serrano, Antonio

“…The immune response type organized against viral infection is determinant in the prognosis of some infections. This work has aimed to study Th polarization in…”
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Immunogenicity of Anti-SARS-CoV-2 Vaccines in Common Variable Immunodeficiency by Arroyo-Sánchez, Daniel, Cabrera-Marante, Oscar, Laguna-Goya, Rocío, Almendro-Vázquez, Patricia, Carretero, Octavio, Gil-Etayo, Francisco Javier, Suàrez-Fernández, Patricia, Pérez-Romero, Pilar, Rodríguez de Frías, Edgard, Serrano, Antonio, Allende, Luis M., Pleguezuelo, Daniel, Paz-Artal, Estela

“…Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and/or a defective antibody response to T-dependent and T-independent…”
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Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management by López-Nevado, Marta, González-Granado, Luis I., Ruiz-García, Raquel, Pleguezuelo, Daniel, Cabrera-Marante, Oscar, Salmón, Nerea, Blanco-Lobo, Pilar, Domínguez-Pinilla, Nerea, Rodríguez-Pena, Rebeca, Sebastián, Elena, Cruz-Rojo, Jaime, Olbrich, Peter, Ruiz-Contreras, Jesús, Paz-Artal, Estela, Neth, Olaf, Allende, Luis M.

“…Primary immune regulatory disorders (PIRD) are associated with autoimmunity, autoinflammation and/or dysregulation of lymphocyte homeostasis. Autoimmune…”
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Immunologic evaluation and genetic defects of apoptosis in patients with autoimmune lymphoproliferative syndrome (ALPS) by Casamayor-Polo, Laura, López-Nevado, Marta, Paz-Artal, Estela, Anel, Alberto, Rieux-Laucat, Frederic, Allende, Luis M.

“…Apoptosis plays an important role in controlling the adaptive immune response and general homeostasis of the immune cells, and impaired apoptosis in the immune…”
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Longitudinal dynamics of SARS-CoV-2-specific cellular and humoral immunity after natural infection or BNT162b2 vaccination by Almendro-Vázquez, Patricia, Laguna-Goya, Rocio, Ruiz-Ruigomez, Maria, Utrero-Rico, Alberto, Lalueza, Antonio, Maestro de la Calle, Guillermo, Delgado, Pilar, Perez-Ordoño, Luis, Muro, Eva, Vila, Juan, Zamarron, Isabel, Moreno-Batanero, Miguel, Chivite-Lacaba, Marta, Gil-Etayo, Francisco Javier, Martín-Higuera, Carmen, Meléndez-Carmona, María Ángeles, Lumbreras, Carlos, Arellano, Irene, Alarcon, Balbino, Allende, Luis Miguel, Aguado, Jose Maria, Paz-Artal, Estela

“…The timing of the development of specific adaptive immunity after natural SARS-CoV-2 infection, and its relevance in clinical outcome, has not been…”
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Perforin gene variant A91V in young patients with severe COVID-19 by Cabrera-Marante, Oscar, Rodríguez de Frías, Edgard, Pleguezuelo, Daniel E, Allende, Luis M, Serrano, Antonio, Laguna-Goya, Rocío, Mancebo, María Esther, Talayero, Paloma, Álvarez-Vallina, Luis, Morales, Pablo, Castro-Panete, Maria José, Paz-Artal, Estela

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Effective Natural Killer Cell Degranulation Is an Essential Key in COVID-19 Evolution by Garcinuño, Sara, Gil-Etayo, Francisco Javier, Mancebo, Esther, López-Nevado, Marta, Lalueza, Antonio, Díaz-Simón, Raquel, Pleguezuelo, Daniel Enrique, Serrano, Manuel, Cabrera-Marante, Oscar, Allende, Luis M., Paz-Artal, Estela, Serrano, Antonio

“…NK degranulation plays an important role in the cytotoxic activity of innate immunity in the clearance of intracellular infections and is an important factor…”
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Hemodialysis-Associated Immune Dysregulation in SARS-CoV-2-Infected End-Stage Renal Disease Patients by González-Cuadrado, Cecilia, Caro-Espada, Paula Jara, Chivite-Lacaba, Marta, Utrero-Rico, Alberto, Lozano-Yuste, Claudia, Gutierrez-Solis, Elena, Morales, Enrique, Sandino-Pérez, Justo, Gil-Etayo, Francisco Javier, Allende-Martínez, Luis, Laguna-Goya, Rocio, Paz-Artal, Estela

“…Patients on hemodialysis show dysregulated immunity, basal hyperinflammation and a marked vulnerability to COVID-19. We evaluated the immune profile in…”
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Patients with CD3G mutations reveal a role for human CD3γ in T reg diversity and suppressive function by Rowe, Jared H, Delmonte, Ottavia M, Keles, Sevgi, Stadinski, Brian D, Dobbs, Adam K, Henderson, Lauren A, Yamazaki, Yasuhiro, Allende, Luis M, Bonilla, Francisco A, Gonzalez-Granado, Luis I, Celikbilek Celik, Seyma, Guner, Sukru N, Kapakli, Hasan, Yee, Christina, Pai, Sung-Yun, Huseby, Eric S, Reisli, Ismail, Regueiro, Jose R, Notarangelo, Luigi D

“…Integrity of the T-cell receptor/CD3 complex is crucial for positive and negative selection of T cells in the thymus and for effector and regulatory functions…”
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The lack of either IRF9, or STAT2, has surprisingly little effect on human natural killer cell development and function by Calvo‐Apalategi, Ane, Nevado, Marta López, Bravo‐Gallego, Luz Yadira, González‐Granado, Luis Ignacio, Allende, Luis M., Pena, Rebeca Rodríguez, López‐Granados, Eduardo, Reyburn, Hugh T.

“…Analysis of genetically defined immunodeficient patients allows study of the effect of the absence of specific proteins on human immune function in real‐world…”
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Inborn Error of STAT2-Dependent IFN-I Immunity in a Patient Presented with Hemophagocytic Lymphohistiocytosis and Multisystem Inflammatory Syndrome in Children by López-Nevado, Marta, Sevilla, Julián, Almendro-Vázquez, Patricia, Gil-Etayo, Francisco J., Garcinuño, Sara, Serrano-Hernández, Antonio, Paz-Artal, Estela, González-Granado, Luis I., Allende, Luis M.

“…Human inborn errors of immunity (IEI) affecting the type I interferon (IFN-I) induction pathway have been associated with predisposition to severe viral…”
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TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, and murine studies by Boast, Brigette, Goel, Shubham, González-Granado, Luis I., Niemela, Julie, Stoddard, Jennifer, Edwards, Emily S.J., Seneviratne, Sandali, Spensberger, Dominik, Quesada-Espinosa, Juan F., Allende, Luis M., McDonnell, John, Haseley, Alexandria, Lesmana, Harry, Walkiewicz, Magdalena A., Muhammad, Emad, Bosco, Julian J., Fleisher, Thomas A., Cohen, Shai, Holland, Steven M., van Zelm, Menno C., Enders, Anselm, Kuehn, Hye Sun, Rosenzweig, Sergio D.

“…[Display omitted] TCF3 is a transcription factor contributing to early lymphocyte differentiation. Germline monoallelic dominant negative and biallelic…”
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Mutations in PI3K110δ cause impaired natural killer cell function partially rescued by rapamycin treatment by Ruiz-García, Raquel, Vargas-Hernández, Alexander, Chinn, Ivan K., Angelo, Laura S., Cao, Tram N., Coban-Akdemir, Zeynep, Jhangiani, Shalini N., Meng, Qingchang, Forbes, Lisa R., Muzny, Donna M., Allende, Luis M., Ehlayel, Mohammed S., Gibbs, Richard A., Lupski, James R., Uzel, Gulbu, Orange, Jordan S., Mace, Emily M.

“…Heterozygous gain-of-function mutations in PI3K110δ lead to lymphadenopathy, lymphoid hyperplasia, EBV and cytomegalovirus viremia, and sinopulmonary…”
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Altered CXCR4 dynamics at the cell membrane impairs directed cell migration in WHIM syndrome patients by García-Cuesta, Eva M, Rodríguez-Frade, José Miguel, Gardeta, Sofía R, D'Agostino, Gianluca, Martínez, Pablo, Soler Palacios, Blanca, Cascio, Graciela, Wolf, Tobias, Mateos, Nicolas, Ayala-Bueno, Rosa, Santiago, César A, Lucas, Pilar, Llorente, Lucia, Allende, Luis M, González-Granado, Luis Ignacio, Martín-Cófreces, Noa, Roda-Navarro, Pedro, Sallusto, Federica, Sánchez-Madrid, Francisco, García-Parajo, María F, Martínez-Muñoz, Laura, Mellado, Mario

“…SignificanceNew imaging-based approaches are incorporating new concepts to our knowledge of biological processes. The analysis of receptor dynamics involved in…”
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CD19 + B-Cells, a New Biomarker of Mortality in Hemodialysis Patients by Molina, María, Allende, Luis M, Ramos, Luis E, Gutiérrez, Eduardo, Pleguezuelo, Daniel E, Hernández, Eduardo R, Ríos, Francisco, Fernández, Cristina, Praga, Manuel, Morales, Enrique

“…Mortality of patients on hemodialysis (HD) remains very high despite recent improvements in HD techniques. Cardiovascular (CV) complications and infections are…”
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Clinical and Immunological Features of Human BCL10 Deficiency by Garcia-Solis, Blanca, Van Den Rym, Ana, Pérez-Caraballo, Jareb J, Al-Ayoubi, Abdulwahab, Alazami, Anas M, Lorenzo, Lazaro, Cubillos-Zapata, Carolina, López-Collazo, Eduardo, Pérez-Martínez, Antonio, Allende, Luis M, Markle, Janet, Fernández-Arquero, Miguel, Sánchez-Ramón, Silvia, Recio, Maria J, Casanova, Jean-Laurent, Mohammed, Reem, Martinez-Barricarte, Rubén, Pérez de Diego, Rebeca

“…The CARD-BCL10-MALT1 (CBM) complex is critical for the proper assembly of human immune responses. The clinical and immunological consequences of deficiencies…”
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RAAOT-ACARO by Allende, Bartolomé Luis

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Next Generation Sequencing for Detecting Somatic FAS Mutations in Patients With Autoimmune Lymphoproliferative Syndrome by López-Nevado, Marta, Docampo-Cordeiro, Jorge, Ramos, José T, Rodríguez-Pena, Rebeca, Gil-López, Celia, Sánchez-Ramón, Silvia, Gil-Herrera, Juana, Díaz-Madroñero, María J, Delgado-Martín, María A, Morales-Pérez, Pablo, Paz-Artal, Estela, Magerus, Aude, Rieux-Laucat, Frederic, Allende, Luis M

“…Autoimmune lymphoproliferative syndrome (ALPS) is a primary immune regulatory disorder clinically defined by chronic and benign lymphoproliferation,…”
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Fatal Pneumocystis jirovecii and Cytomegalovirus Infections in an Infant With Normal TRECs Count: Pitfalls of Newborn Screening for Severe Combined Immunodeficiency by Mendez-Echevarria, Ana, Gonzalez-Granado, Luis Ignacio, Allende, Luis M, De Felipe, Beatriz, Teresa, Del Rosal, Calvo, Cristina, Perez-Martinez, Antonio, Raquel, Ruiz-Garcia, Neth, Olaf

“…Newborn screening for severe combined immunodeficiency using T-cell receptor excision circles allows prompt diagnosis and initiation of supportive and curative…”
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Enrichment of Immune Dysregulation Disorders in Adult Patients with Human Inborn Errors of Immunity by Segura-Tudela, Alejandro, López-Nevado, Marta, Nieto-López, Celia, García-Jiménez, Sandra, Díaz-Madroñero, María J., Delgado, Ángeles, Cabrera-Marante, Oscar, Pleguezuelo, Daniel, Morales, Pablo, Paz-Artal, Estela, Gil-Niño, Jorge, Marco, Francisco M., Serrano, Cristina, González-Granado, Luis I., Quesada-Espinosa, Juan F., Allende, Luis M.

“…Human inborn errors of immunity (IEI) comprise a group of diseases resulting from molecular variants that compromise innate and adaptive immunity. Clinical…”
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