Search Results - "Allen, Shelley J."

The microbiome and disease: reviewing the links between the oral microbiome, aging, and Alzheimer's disease by Shoemark, Deborah K, Allen, Shelley J

“…This review, gathered from diverse sources, shows how our microbiome influences health and ultimately how well we age. Evidence linking oral bacteria to…”
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GDNF, NGF and BDNF as therapeutic options for neurodegeneration by ALLEN, Shelley J, WATSON, Judy J, SHOEMARK, Deborah K, BARUA, Neil U, PATEL, Nikunj K

“…Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are important for…”
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16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer's Post-Mortem Brain by Emery, David C, Shoemark, Deborah K, Batstone, Tom E, Waterfall, Christy M, Coghill, Jane A, Cerajewska, Tanya L, Davies, Maria, West, Nicola X, Allen, Shelley J

“…The neurological deterioration associated with Alzheimer's disease (AD), involving accumulation of amyloid-beta peptides and neurofibrillary tangles, is…”
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The Neurotrophins and Their Role in Alzheimers Disease by Allen, Shelley J, Watson, Judy J, Dawbarn, David

“…Besides being essential for correct development of the vertebrate nervous system the neurotrophins also play a vital role in adult neuron survival, maintenance…”
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Clinical relevance of the neurotrophins and their receptors by Allen, Shelley J, Dawbarn, David

“…The neurotrophins are growth factors required by discrete neuronal cell types for survival and maintenance, with a broad range of activities in the central and…”
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High resolution 16S rRNA gene Next Generation Sequencing study of brain areas associated with Alzheimer's and Parkinson's disease by Emery, David C, Davies, Maria, Cerajewska, Tanya L, Taylor, Jelena, Hazell, Mae, Paterson, Alex, Allen-Birt, Shelley J, West, Nicola X

“…Alzheimer's (AD) and Parkinson's disease (PD) are neurodegenerative conditions characterized by incremental deposition of β-amyloid (Aβ) and α-synuclein in AD…”
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Biological Activity of Nerve Growth Factor Precursor Is Dependent upon Relative Levels of Its Receptors by Masoudi, Raheleh, Ioannou, Maria S., Coughlin, Michael D., Pagadala, Promila, Neet, Kenneth E., Clewes, Oliver, Allen, Shelley J., Dawbarn, David, Fahnestock, Margaret

“…Nerve growth factor (NGF) is produced as a precursor called pro-nerve growth factor (proNGF), which is secreted by many tissues and is the predominant form of…”
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Comparison of Blood Bacterial Communities in Periodontal Health and Periodontal Disease by Emery, David C, Cerajewska, Tanya L, Seong, Joon, Davies, Maria, Paterson, Alex, Allen-Birt, Shelley J, West, Nicola X

“…The use of Next Generation Sequencing (NGS) techniques has generated a wide variety of blood microbiome data. Due to the large variation in bacterial DNA…”
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Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling by Crompton, Lucy A, Byrne, Meg L, Taylor, Hannah, Kerrigan, Talitha L, Bru-Mercier, Gilles, Badger, Jennifer L, Barbuti, Peter A, Jo, Jihoon, Tyler, Sue J, Allen, Shelley J, Kunath, Tilo, Cho, Kwangwook, Caldwell, Maeve A

“…Basal forebrain cholinergic neurons (bfCNs) which provide innervation to the hippocampus and cortex, are required for memory and learning, and are primarily…”
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Premorbid effects of APOE on synaptic proteins in human temporal neocortex by Love, Seth, Siew, L. Khai, Dawbarn, David, Wilcock, Gordon K., Ben-Shlomo, Yoav, Allen, Shelley J.

“…APOE affects the risk of Alzheimer's disease (AD) and course of several other neurologic diseases. Experimental studies suggest that APOE influences…”
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Mini Review: Opposing Pathologies in Cancer and Alzheimer's Disease: Does the PI3K/Akt Pathway Provide Clues? by Barker, Rachel M, Holly, Jeff M P, Biernacka, Kalina M, Allen-Birt, Shelley J, Perks, Claire M

“…This minireview is a brief overview examining the roles of insulin-like growth factors (IGFs) and the PI3K/Akt pathway in two apparently unconnected diseases:…”
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TrkAd5: A novel therapeutic agent for treatment of inflammatory pain and asthma by Watson, Judy J, Fahey, Mark S, van den Worm, Edwin, Engels, Ferdi, Nijkamp, Frans P, Stroemer, Paul, McMahon, Steve, Allen, Shelley J, Dawbarn, David

“…Elevated levels of nerve growth factor have been linked to the onset and persistence of many pain-related disorders and asthma. Described here are the design,…”
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Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain by McNamee, Kay E., Burleigh, Annika, Gompels, Luke L., Feldmann, Marc, Allen, Shelley J., Williams, Richard O., Dawbarn, David, Vincent, Tonia L., Inglis, Julia J.

“…The origin of pain in osteoarthritis is poorly understood, but it is generally thought to arise from inflammation within the innervated structures of the…”
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Targeting Nerve Growth Factor in Pain: What is the Therapeutic Potential? by Watson, Judy J., Allen, Shelley J., Dawbarn, DrDavid

“…Chronic pain presents a huge economic and social burden, with existing treatments largely unable to satisfy medical needs. Recently, studies have shown that…”
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Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF) by Kailainathan, Sumangali, Piers, Thomas M., Yi, Jee Hyun, Choi, Seongmin, Fahey, Mark S., Borger, Eva, Gunn-Moore, Frank J., O’Neill, Laurie, Lever, Michael, Whitcomb, Daniel J., Cho, Kwangwook, Allen, Shelley J.

“…[Display omitted] This study describes a fundamental functional difference between the two main polymorphisms of the pro-form of brain-derived neurotrophic…”
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alpha- and beta-secretase: profound changes in Alzheimer's disease by Tyler, Susan J, Dawbarn, David, Wilcock, Gordon K, Allen, Shelley J

“…The amyloid plaque, a neuropathological hallmark of Alzheimer's disease, is produced by the deposition of beta-amyloid (Abeta) peptide, which is cleaved from…”
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A Discrete Domain of the Human TrkB Receptor Defines the Binding Sites for BDNF and NT-4 by Naylor, Ruth L, Robertson, Alan G.S, Allen, Shelley J, Sessions, Richard B, Clarke, Anthony R, Mason, Grant G.F, Burston, Judy J, Tyler, Sue J, Wilcock, Gordon K, Dawbarn, David

“…TrkB is a member of the Trk family of tyrosine kinase receptors. In vivo, the extracellular region of TrkB is known to bind, with high affinity, the…”
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Design and Nuclear Magnetic Resonance (NMR) Structure Determination of the Second Extracellular Immunoglobulin Tyrosine Kinase A (TrkAIg2) Domain Construct for Binding Site Elucidation in Drug Discovery by Shoemark, Debbie K, Williams, Christopher, Fahey, Mark S, Watson, Judy J, Tyler, Sue J, Scoltock, Simon J, Ellis, Rosamund Z, Wickenden, Elaine, Burton, Antony J, Hemmings, Jennifer L, Bailey, Christopher D, Dawbarn, David, Jane, David E, Willis, Christine L, Sessions, Richard B, Allen, Shelley J, Crump, Matthew P

“…The tyrosine kinase A (TrkA) receptor is a validated therapeutic intervention point for a wide range of conditions. TrkA activation by nerve growth factor…”
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A feasibility study to recruit, retain and treat periodontitis in volunteers with mild dementia, whilst monitoring their cognition by Cerajewska, Tanya L, Davies, Maria, Allen-Birt, Shelley J, Swirski, Marta, Coulthard, Elizabeth J, West, Nicola X

“…Dementia patients are challenging to manage dentally. This study determined whether individuals with mild dementia and periodontitis, could be recruited,…”
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Identification of novel small molecule TGF-β antagonists using structure-based drug design by Wang, Hao, Sessions, Richard B., Prime, Stephen S., Shoemark, Deborah K., Allen, Shelley J., Hong, Wei, Narayanan, Sathya, Paterson, Ian C.

“…Aberrant transforming growth factor-β (TGF-β) signalling has been associated with a number of disease pathologies, such as the development of fibrosis in the…”
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