Search Results - "Allen, Shane C."
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Dynamic phototuning of 3D hydrogel stiffness
Published in Proceedings of the National Academy of Sciences - PNAS (17-02-2015)“…Significance Extracellular matrix (ECM) stiffness is an influential factor in many biological processes. Temporal changes in ECM stiffness are observed in…”
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Phenotypic Basis for Matrix Stiffness-Dependent Chemoresistance of Breast Cancer Cells to Doxorubicin
Published in Frontiers in oncology (05-09-2018)“…The persistence of drug resistant cell populations following chemotherapeutic treatment is a significant challenge in the clinical management of cancer…”
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The applicability of furfuryl-gelatin as a novel bioink for tissue engineering applications
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01-02-2019)“…Three-dimensional bioprinting is an innovative technique in tissue engineering, to create layer-by-layer structures, required for mimicking body tissues…”
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Dynamic extracellular matrix stiffening induces a phenotypic transformation and a migratory shift in epithelial cells
Published in Integrative biology (Cambridge) (19-06-2020)“…Abstract Soft tissue tumors, including breast cancer, become stiffer throughout disease progression. This increase in stiffness has been shown to correlate to…”
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A Visible Light-Cross-Linkable, Fibrin–Gelatin-Based Bioprinted Construct with Human Cardiomyocytes and Fibroblasts
Published in ACS biomaterials science & engineering (09-09-2019)“…In this study, fibrin was added to a photopolymerizable gelatin-based bioink mixture to fabricate cardiac cell-laden constructs seeded with human induced…”
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Extracellular Matrix Stiffening Induces a Malignant Phenotypic Transition in Breast Epithelial Cells
Published in Cellular and molecular bioengineering (01-02-2017)“…Tumors are much stiffer than healthy tissue, and progressively stiffen as the cancer develops. Tumor stiffening is largely the result of extracellular matrix…”
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A Model for Studying the Biomechanical Effects of Varying Ratios of Collagen Types I and III on Cardiomyocytes
Published in Cardiovascular engineering and technology (01-06-2021)“…Purpose To develop a novel model composed solely of Col I and Col III with the lower and upper limits set to include the ratios of Col I and Col III at 3:1 and…”
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