Search Results - "Allen, Martin J."

Rational design of viscosity reducing mutants of a monoclonal antibody: hydrophobic versus electrostatic inter-molecular interactions by Nichols, Pilarin, Li, Li, Kumar, Sandeep, Buck, Patrick M, Singh, Satish K, Goswami, Sumit, Balthazor, Bryan, Conley, Tami R, Sek, David, Allen, Martin J

“…High viscosity of monoclonal antibody formulations at concentrations ≥100 mg/mL can impede their development as products suitable for subcutaneous delivery…”
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Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms by Wypych, Jette, Li, Ming, Guo, Amy, Zhang, Zhongqi, Martinez, Theresa, Allen, Martin J., Fodor, Szilan, Kelner, Drew N., Flynn, Gregory C., Liu, Yaoqing Diana, Bondarenko, Pavel V., Ricci, Margaret Speed, Dillon, Thomas M., Balland, Alain

“…In this work, we present studies of the covalent structure of human IgG2 molecules. Detailed analysis showed that recombinant human IgG2 monoclonal antibody…”
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Rational optimization of a monoclonal antibody for simultaneous improvements in its solution properties and biological activity by Kumar, Sandeep, Roffi, Kirk, Tomar, Dheeraj S, Cirelli, David, Luksha, Nicholas, Meyer, Danielle, Mitchell, Jeffrey, Allen, Martin J, Li, Li

“…Abstract Developability considerations should be integrated with lead engineering of antibody drug candidates in interest of their cost effective translations…”
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Disulfide Connectivity of Human Immunoglobulin G2 Structural Isoforms by Martinez, Theresa, Guo, Amy, Allen, Martin J, Han, Mei, Pace, Danielle, Jones, Jay, Gillespie, Ron, Ketchem, Randal R, Zhang, Yuling, Balland, Alain

“…In this communication we present the detailed disulfide structure of IgG2 molecules. The consensus structural model of human IgGs represents the hinge region…”
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Molecular and functional characterization of cynomolgus monkey IgG subclasses by Jacobsen, Frederick W, Padaki, Rupa, Morris, Arvia E, Aldrich, Teri L, Armitage, Richard J, Allen, Martin J, Lavallee, Jennifer C, Arora, Taruna

“…Studies for vaccine and human therapeutic Ab development in cynomolgus monkeys (cynos) are influenced by immune responses, with Ab responses playing a…”
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Identification of novel small molecule enhancers of protein production by cultured mammalian cells by Allen, Martin J., Boyce, James P., Trentalange, Michael T., Treiber, David L., Rasmussen, Brian, Tillotson, Benjamin, Davis, Raymond, Reddy, Pranhitha

“…Small molecule additives to cell culture media (e.g., sodium butyrate) that are capable of enhancing the expression of recombinant proteins have significant…”
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Microbial monitoring of drinking water prevents waterborne diseases—and the moon is made of green cheese by Allen, Martin J., Clancy, Jennifer L., Kirmeyer, Ory, Grigg, Neil S.

“…Microbial monitoring as currently practiced falls far short of the intended purpose of ensuring the microbial safety of drinking water…”
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CHOK1SV GS‐KO SSI expression system: A combination of the Fer1L4 locus and glutamine synthetase selection by Feary, Marc, Moffat, Mark A., Casperson, Gerald F., Allen, Martin J., Young, Robert J.

“…There are an ever‐increasing number of biopharmaceutical candidates in clinical trials fueling an urgent need to streamline the cell line development process…”
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Strategic deployment of CHO expression platforms to deliver Pfizer's Monoclonal Antibody Portfolio by Scarcelli, John J., Shang, Tanya Q., Iskra, Tim, Allen, Martin J., Zhang, Lin

“…Development of stable cell lines for expression of large‐molecule therapeutics represents a significant portion of the time and effort required to advance a…”
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Interactions of Surfactant Proteins A and D with Saccharomyces cerevisiae and Aspergillus fumigatus by ALLEN, Martin J, VOELKER, Dennis R, MASON, Robert J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Heterotrophic plate count bacteria—what is their significance in drinking water? by Allen, Martin J, Edberg, Stephen C, Reasoner, Donald J

“…While the literature documents the universal occurrence of heterotrophic plate count (HPC) bacteria in soils, foods, air, and all sources of water, there is a…”
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Serum SP-D is a marker of lung injury in rats by Pan, Tianli, Nielsen, Larry D, Allen, Martin J, Shannon, Kathleen M, Shannon, John M, Selman, Moises, Mason, Robert J

“…Pulmonary surfactant protein D (SP-D) is expressed in alveolar type II and bronchiolar epithelial cells and is secreted into alveoli and conducting airways…”
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Health concerns of heterotrophic plate count (HPC) bacteria in dental equipment water lines by Allen, Martin J, Edberg, Stephen C

“…There is an unsubstantiated concern as to the health relevance of HPC (heterotrophic plate count) bacteria in dental equipment waterlines. The American Dental…”
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Drinking water microbial myths by Allen, Martin J, Edberg, Stephen C, Clancy, Jennifer L, Hrudey, Steve E

“…Accounts of drinking water-borne disease outbreaks have always captured the interest of the public, elected and health officials, and the media. During the…”
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Interchain Disulfide Bonding in Human IgG2 Antibodies Probed by Site-Directed Mutagenesis by Allen, Martin J, Guo, Amy, Martinez, Theresa, Han, Mei, Flynn, Gregory C, Wypych, Jette, Liu, Yaoqing Diana, Shen, Wenyan D, Dillon, Thomas M, Vezina, Christopher, Balland, Alain

“…Human IgG2 exists as a mixture of disulfide-linked structural isoforms that can show different activities. To probe the contribution of specific cysteine…”
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Issues for microbial regulation: Aeromonas as a model by Edberg, Stephen C, Browne, Frederick A, Allen, Martin J

“…The decision by public health agencies to regulate specific microorganisms that may be found in drinking water can only be made if specific criteria find that…”
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Virulence and risk from drinking water of heterotrophic plate count bacteria in human population groups by Edberg, Stephen C, Allen, Martin J

“…Bacteria are natural inhabitants of all aqueous environments. The heterotrophic plate count is a means of assessing the concentration of these bacteria in…”
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Rapid microbial methods can improve public health protection by ALLEN, MARTIN J., PAYMENT, PIERRE, CLANCY, JENNIFER L.

“…Regulatory, political, and institutional barriers have prevented broader use of rapid, simple, and inexpensive microbiological tests for Escherichia coli. By…”
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Binding of Rat and Human Surfactant Proteins A and D to Aspergillus fumigatus Conidia by ALLEN, M. J, HARBECK, R, SMITH, B, VOELKER, D. R, MASON, R. J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Polysaccharide Recognition by Surfactant Protein D:  Novel Interactions of a C-Type Lectin with Nonterminal Glucosyl Residues by Allen, Martin J, Laederach, Alain, Reilly, Peter J, Mason, Robert J

“…Surfactant protein D (SP-D), a C-type lectin, is an important pulmonary host defense molecule. Carbohydrate binding is critical to its host defense properties,…”
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