Search Results - "Allen, C Leigh"

Structures of two distinct conformations of holo-non-ribosomal peptide synthetases by Drake, Eric J., Miller, Bradley R., Shi, Ce, Tarrasch, Jeffrey T., Sundlov, Jesse A., Leigh Allen, C., Skiniotis, Georgios, Aldrich, Courtney C., Gulick, Andrew M.

“…X-ray crystal structures of two distinct steps in the catalytic cycle of non-ribosomal peptide synthetases are described, offering the potential to generate…”
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Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis by Hanna, Carol B, Mudaliar, Deepti, John, Kristen, Allen, C. Leigh, Sun, Luxin, Hawkinson, Jon E, Schönbrunn, Ernst, Georg, Gunda I, Jensen, Jeffrey T

“…WEE2 oocyte meiosis inhibiting kinase is a well-conserved oocyte specific kinase with a dual regulatory role during meiosis. Active WEE2 maintains immature,…”
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N -Butyldeoxygalactonojirimycin Induces Reversible Infertility in Male CD Rats by Gupta, Vijayalaxmi, Hild, Sheri A, Jakkaraj, Sudhakar R, Carlson, Erick J, Wong, Henry L, Allen, C. Leigh, Georg, Gunda I, Tash, Joseph S

“…This study shows for the first time that an iminosugar exerts anti-spermiogenic effect, inducing reversible infertility in a species that is not related to…”
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Biomedical, socio-behavioral, and implementation science gaps in multipurpose prevention technology research by Cummins, James E., Allen, C. Leigh, Lee, Sonia, Senn, Theresa E.

“…There is strong global need for the development of Multipurpose Prevention Technologies (MPTs) that prevent HIV, pregnancy, and/or other sexually transmitted…”
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Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections by Draughn, G Logan, Allen, C Leigh, Routh, Patricia A, Stone, Maria R, Kirker, Kelly R, Boegli, Laura, Schuchman, Ryan M, Linder, Keith E, Baynes, Ronald E, James, Garth, Melander, Christian, Pollard, Angela, Cavanagh, John

“…2-Aminoimidazole (2-AI)-based compounds have been shown to efficiently disrupt biofilm formation, disperse existing biofilms, and resensitize numerous…”
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The Role of Phosphate in a Multistep Enzymatic Reaction: Reactions of the Substrate and Intermediate in Pieces by Kholodar, Svetlana A, Allen, C. Leigh, Gulick, Andrew M, Murkin, Andrew S

“…Several mechanistically unrelated enzymes utilize the binding energy of their substrate’s nonreacting phosphoryl group to accelerate catalysis. Evidence for…”
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Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2‐aminoimidazole‐based compounds by Milton, Morgan E., Allen, C. Leigh, Feldmann, Erik A., Bobay, Benjamin G., Jung, David K., Stephens, Matthew D., Melander, Roberta J., Theisen, Kelly E., Zeng, Daina, Thompson, Richele J., Melander, Christian, Cavanagh, John

“…Summary With antibiotic resistance increasing at alarming rates, targets for new antimicrobial therapies must be identified. A particularly promising target is…”
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Structural and bioinformatic characterization of an Acinetobacter baumannii type II carrier protein by Allen, C. Leigh, Gulick, Andrew M.

“…Microorganisms produce a variety of natural products via secondary metabolic biosynthetic pathways. Two of these types of synthetic systems, the nonribosomal…”
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Alteration of the Flexible Loop in 1‑Deoxy‑d‑xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by Fosmidomycin by Kholodar, Svetlana A, Tombline, Gregory, Liu, Juan, Tan, Zhesen, Allen, C. Leigh, Gulick, Andrew M, Murkin, Andrew S

“…1-Deoxy-d-xylulose-5-phosphate reductoisomerase (DXR), which catalyzes the first committed step in the 2-C-methyl-d-erythritol 4-phosphate pathway of…”
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Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds: Inhibition of response regulator QseB by antibiofilm compounds by Milton, Morgan E., Allen, C. Leigh, Feldmann, Erik A., Bobay, Benjamin G., Jung, David K., Stephens, Matthew D., Melander, Roberta J., Theisen, Kelly E., Zeng, Daina, Thompson, Richele J., Melander, Christian, Cavanagh, John

“…With antibiotic resistance increasing at alarming rates, targets for new antimicrobial therapies must be identified. A particularly promising target is the…”
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Structures of Two Distinct Conformations of holo-Nonribosomal Peptide Synthetases by Drake, Eric J., Miller, Bradley R., Shi, Ce, Tarrasch, Jeffrey T., Sundlov, Jesse A., Allen, C. Leigh, Skiniotis, Georgios, Aldrich, Courtney C., Gulick, Andrew M.

“…Many important natural products are produced by multidomain nonribosomal peptide synthetases (NRPSs) 1 – 4 . During synthesis, intermediates are covalently…”
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A convenient method for the synthesis of N-hydroxyureas by Parrish, Dennis A., Zou, Zhou, Allen, C. Leigh, Day, Cynthia S., King, S. Bruce

“…Treatment of amines with 1-(4-nitrophenol)- N-( O-benzylhydroxy)carbamate yields the O-benzyl protected N-hydroxyureas. Hydrogenation of the O-benzyl protected…”
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