Search Results - "Allen, Bruce"

Isolation and culture of adult murine cardiac atrial and ventricular fibroblasts and myofibroblasts by Sahadevan, Pramod, Allen, Bruce G.

“…•Fibroblasts can be isolated from mouse or rat cardiac ventricles or atria.•Yield sufficient to study the effects of pharmacological or molecular…”
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Role of the lysyl oxidase enzyme family in cardiac function and disease by Al-u’datt, Doa’a, Allen, Bruce G, Nattel, Stanley

“…Abstract Heart diseases are a major cause of morbidity and mortality world-wide. Lysyl oxidase (LOX) and related LOX-like (LOXL) isoforms play a vital role in…”
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Gravitational wave stochastic background from cosmological particle decay by Allen, Bruce

“…We assume that the cosmological dark matter is composed of massive neutral scalar particles that decay into two massless particles. The decay produces a…”
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Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus by Villanueva, Eneida, Yalavarthi, Srilakshmi, Berthier, Celine C, Hodgin, Jeffrey B, Khandpur, Ritika, Lin, Andrew M, Rubin, Cory J, Zhao, Wenpu, Olsen, Stephen H, Klinker, Matthew, Shealy, David, Denny, Michael F, Plumas, Joel, Chaperot, Laurence, Kretzler, Matthias, Bruce, Allen T, Kaplan, Mariana J

“…An abnormal neutrophil subset has been identified in the PBMC fractions from lupus patients. We have proposed that these low-density granulocytes (LDGs) play…”
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BMDExpress: a software tool for the benchmark dose analyses of genomic data by Yang, Longlong, Allen, Bruce C, Thomas, Russell S

“…Dose-dependent processes are common within biological systems and include phenotypic changes following exposures to both endogenous and xenobiotic molecules…”
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Benchmark dose (BMD) modeling: current practice, issues, and challenges by Haber, Lynne T., Dourson, Michael L., Allen, Bruce C., Hertzberg, Richard C., Parker, Ann, Vincent, Melissa J., Maier, Andrew, Boobis, Alan R.

“…Benchmark dose (BMD) modeling is now the state of the science for determining the point of departure for risk assessment. Key advantages include the fact that…”
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Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis by Lin, Andrew M, Rubin, Cory J, Khandpur, Ritika, Wang, Jennifer Y, Riblett, MaryBeth, Yalavarthi, Srilakshmi, Villanueva, Eneida C, Shah, Parth, Kaplan, Mariana J, Bruce, Allen T

“…IL-17 and IL-23 are known to be absolutely central to psoriasis pathogenesis because drugs targeting either cytokine are highly effective treatments for this…”
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Cardiac remodelling patterns and proteomics: the keys to move beyond ejection fraction in heart failure? by O'Meara, Eileen, Allen, Bruce G.

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Meta-regression analysis of the effects of dietary cholesterol intake on LDL and HDL cholesterol by Vincent, Melissa J, Allen, Bruce, Palacios, Orsolya M, Haber, Lynne T, Maki, Kevin C

“…Elevated low-density lipoprotein (LDL) cholesterol is a major risk factor for cardiovascular disease. Dietary guidance recommends reducing saturated fatty…”
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The WIL to learn: students' perspectives on the impact of work-integrated learning placements on their professional readiness by Aprile, Kerry Therese, Knight, Bruce Allen

“…Work-integrated learning (WIL) has assumed life as a central feature of higher education curriculum design in a wide range of disciplines with the ultimate…”
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MK5: A novel regulator of cardiac fibroblast function? by Sahadevan, Pramod, Allen, Bruce G.

“…MAP kinase‐activated protein kinases (MKs), protein serine/threonine kinases downstream of the MAPKs, regulate a number of biological functions. MK5 was…”
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Current knowledge into the role of the peptidylarginine deiminase (PAD) enzyme family in cardiovascular disease by Al-U'datt, Doa'a G.F., Allen, Bruce G., Hiram, Roddy, Alrabadi, Nasr

“…Peptidylarginine deiminase (PAD) family members have a vital role in maintaining the stability of the extracellular matrix (ECM) during remodelling in several…”
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Molecular Dissection of Psoriasis: Integrating Genetics and Biology by Elder, James T., Bruce, Allen T., Gudjonsson, Johann E., Johnston, Andrew, Stuart, Philip E., Tejasvi, Trilokraj, Voorhees, John J., Abecasis, Gonçalo R., Nair, Rajan P.

“…Psoriasis is a common and debilitating disease of the skin, nails, and joints, with an acknowledged but complex genetic basis. Early genome-wide linkage…”
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Temporal concordance between apical and transcriptional points of departure for chemical risk assessment by Thomas, Russell S, Wesselkamper, Scott C, Wang, Nina Ching Y, Zhao, Q Jay, Petersen, Dan D, Lambert, Jason C, Cote, Ila, Yang, Longlong, Healy, Eric, Black, Michael B, Clewell, 3rd, Harvey J, Allen, Bruce C, Andersen, Melvin E

“…The number of legacy chemicals without toxicity reference values combined with the rate of new chemical development is overwhelming the capacity of the…”
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Vascular CaMKII: heart and brain in your arteries by Toussaint, Fanny, Charbel, Chimène, Allen, Bruce G, Ledoux, Jonathan

“…First characterized in neuronal tissues, the multifunctional calcium/calmodulin-dependent protein kinase II (CaMKII) is a key signaling component in several…”
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A model of functional thyroid disease status over the lifetime by Dzierlenga, Michael W, Allen, Bruce C, Ward, Peyton L, Clewell, 3rd, Harvey J, Longnecker, Matthew P

“…Mathematical models of the natural history of disease can predict incidence rates based on prevalence data and support simulations of populations where thyroid…”
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Impact of updated BMD modeling methods on perchlorate and chlorate assessments of human health hazard by Haber, Lynne T., Schoeny, Rita S., Allen, Bruce C.

“…•BMR defined based on definition of RAIU considered abnormal in medical literature.•Bayesian hierarchical modeling was used to account for the repeated…”
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G protein‐coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function by Tadevosyan, Artavazd, Vaniotis, George, Allen, Bruce G., Hébert, Terence E., Nattel, Stanley

“…G protein‐coupled receptors (GPCRs) play key physiological roles in numerous tissues, including the heart, and their dysfunction influences a wide range of…”
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Understanding the impact of nuclear-localized GPCRs on cellular signalling by Allen, Bruce G., Merlen, Clémence, Branco, Ana F., Pétrin, Darlaine, Hébert, Terence E.

“…G protein-coupled receptors (GPCRs) have historically been associated with signalling events driven from the plasma membrane. More recently, signalling from…”
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Pharmacokinetic bias analysis of an association between clinical thyroid disease and two perfluoroalkyl substances by Dzierlenga, Michael W., Allen, Bruce C., Clewell, Harvey J., Longnecker, Matthew P.

“…•Bias was quantified in an association of clinical thyroid disease with PFAS.•A PBPK model was used to link thyroid disease, renal function and PFAS…”
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