Search Results - "Allegaert, K"

Neonatal drug therapy: The first frontier of therapeutics for children by Allegaert, K, van den Anker, J

“…Knowledge about the safe and effective use of medicines in neonates has increased substantially but has resulted in few label changes. Drugs developed for use…”
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Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species by van Groen, B D, Nicolaï, J, Kuik, A C, Van Cruchten, S, van Peer, E, Smits, A, Schmidt, S, de Wildt, S N, Allegaert, K, De Schaepdrijver, L, Annaert, P, Badée, J

“…The liver represents a major eliminating and detoxifying organ, determining exposure to endogenous compounds, drugs, and other xenobiotics. Drug transporters…”
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Determinants of drug absorption in different ECMO circuits by Wildschut, E. D., Ahsman, M. J., Allegaert, K., Mathot, R. A. A., Tibboel, D.

“…Purpose The aim of this in vitro study was to evaluate potential determinants of drug loss in different ECMO circuits. Methods Midazolam, morphine, fentanyl,…”
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Paracetamol to close the patent ductus arteriosus: From serendipity toward evidence based medicine by Allegaert, K

“…[...]there is a need for alternative treatments that result in better closure rates or fewer adverse effects. [...]the peripheral PGH2 inhibition of PGH2…”
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Analgesics and Sedatives in Critically Ill Newborns and Infants: The Impact on Long‐Term Neurodevelopment by Schiller, R.M., Allegaert, K., Hunfeld, Maayke, den Bosch, G.E., den Anker, John, Tibboel, D.

“…Inadequate pain and/or stress management in preterm‐ and term‐born infants has been associated with increased morbidity and even mortality. However, exposure…”
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Observed to expected lung area to head circumference ratio in the prediction of survival in fetuses with isolated diaphragmatic hernia by Jani, J., Nicolaides, K. H., Keller, R. L., Benachi, A., Peralta, C. F. A., Favre, R., Moreno, O., Tibboel, D., Lipitz, S., Eggink, A., Vaast, P., Allegaert, K., Harrison, M., Deprest, J.

“…Objective To assess the value of antenatally determined observed to expected fetal lung area to head circumference ratio (LHR) in the prediction of postnatal…”
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Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: the CDH EURO Consortium consensus by Reiss, I, Schaible, T, van den Hout, L, Capolupo, I, Allegaert, K, van Heijst, A, Gorett Silva, M, Greenough, A, Tibboel, D

“…Congenital diaphragmatic hernia (CDH) is associated with high mortality and morbidity. To date, there are no standardized protocols for the treatment of…”
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Prenatal prediction of survival in isolated diaphragmatic hernia using observed to expected total fetal lung volume determined by magnetic resonance imaging based on either gestational age or fetal body volume by Cannie, M., Jani, J., Meersschaert, J., Allegaert, K., Done', E., Marchal, G., Deprest, J., Dymarkowski, S.

“…Objectives To compare the predictive value of the prenatal observed to expected (o/e) lung volume as measured by fetal magnetic resonance imaging (MRI), based…”
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Inter-individual variability in propofol pharmacokinetics in preterm and term neonates by Allegaert, K., Peeters, M.Y., Verbesselt, R., Tibboel, D., Naulaers, G., de Hoon, J.N., Knibbe, C.A.

“…To document covariates which contribute to inter-individual variability in propofol pharmacokinetics in preterm and term neonates. Population pharmacokinetics…”
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Population pharmacokinetic modelling of intravenous paracetamol in fit older people displays extensive unexplained variability by Mian, P., Esdonk, M. J., Olkkola, K. T., Winter, B. C. M., Liukas, A., Spriet, I., Tibboel, D., Petrovic, M., Koch, B. C. P., Allegaert, K.

“…Aims Paracetamol is the analgesic most used by older people. The physiological changes occurring with ageing influence the pharmacokinetics (PK) of paracetamol…”
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Larger Dose Reductions of Vancomycin Required in Neonates with Patent Ductus Arteriosus Receiving Indomethacin versus Ibuprofen by Cristea, S, Allegaert, K, Falcao, A C, Falcao, F, Silva, R, Smits, A, Knibbe, C A J, Krekels, E H J

“…Ibuprofen and indomethacin are commonly used to induce ductus arteriosus closure in preterm neonates. Our group previously reported that ibuprofen decreased…”
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Prospective Evaluation of a Model-Based Dosing Regimen for Amikacin in Preterm and Term Neonates in Clinical Practice by Smits, A, De Cock, R F W, Allegaert, K, Vanhaesebrouck, S, Danhof, M, Knibbe, C A J

“…Based on a previously derived population pharmacokinetic model, a novel neonatal amikacin dosing regimen was developed. The aim of the current study was to…”
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Predictors of neonatal morbidity in fetuses with severe isolated congenital diaphragmatic hernia undergoing fetoscopic tracheal occlusion by Doné, E., Gratacos, E., Nicolaides, K. H., Allegaert, K., Valencia, C., Castañon, M., Martinez, J.‐M., Jani, J., Van Mieghem, T., Greenough, A., Gomez, O., Lewi, P., Deprest, J.

“…ABSTRACT Objectives To investigate neonatal morbidity in fetuses with severe congenital diaphragmatic hernia (CDH) treated with fetoscopic endoluminal tracheal…”
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Antenatal therapy with sildenafil: don't throw the baby out with the bathwater by Russo, F. M., Hooper, S., Tibboel, D., DeKoninck, P., Benachi, A., Tréluyer, J.‐M., Allegaert, K., Kumar, S., Deprest, J.

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Highly Variable Paracetamol Pharmacokinetics After Multiple Oral Dosing in Frail Older People: A Population Pharmacokinetic Analysis by van der Heijden, L. T., Mian, P., Hias, J., de Winter, B. C. M., Tournoy, J., Van der Linden, L., Tibboel, D., Walgraeve, K., Flamaing, J., Koch, B. C. P., Allegaert, K., Spriet, I.

“…Introduction Paracetamol pharmacokinetics (PK) is highly variable in older fit adults after intravenous administration. Frailty and oral administration likely…”
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Improved pathogen detection in neonatal sepsis to boost antibiotic stewardship by Keij, F M, Kornelisse, R F, Tramper-Stranders, G A, Allegaert, K

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The development of the Belgian paediatric clinical trial network by Degraeuwe, E, Persijn, L, Nuytinck, L, Allegaert, K, De Taeye, L, Gasthuys, E, Christiaens, D, Karamaria, S, Raes, A, Turner, M, Vande Walle, J

“…Paediatric clinical trials are critical to ensure that medications prescribed to children are safe and effective. However, evidence-based dosing and labelling…”
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Prospective assessment of short-term propylene glycol tolerance in neonates by Allegaert, Karel, Vanhaesebrouck, Sophie, Kulo, Aida, Cosaert, Katrien, Verbesselt, Rene, Debeer, Anne, de Hoon, Jan

“…Introduction Propylene glycol (PG) is an unintentional frequently administered solvent in neonates despite the fact that PG accumulation potentially results in…”
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Prenatal prediction of neonatal morbidity in survivors with congenital diaphragmatic hernia: a multicenter study by Jani, J. C., Benachi, A., Nicolaides, K. H., Allegaert, K., Gratacós, E., Mazkereth, R., Matis, J., Tibboel, D., Van Heijst, A., Storme, L., Rousseau, V., Greenough, A., Deprest, J. A.

“…Objectives To investigate the value of the observed to expected fetal lung area to head circumference ratio (o/e LHR) and liver position in the prediction of…”
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The bioavailability and maturing clearance of doxapram in preterm infants by Flint, Robert B., Simons, Sinno H. P., Andriessen, Peter, Liem, Kian D., Degraeuwe, Pieter L. J., Reiss, Irwin K. M., Ter Heine, Rob, Engbers, Aline G. J., Koch, Birgit C. P., Groot, Ronald de, Burger, David M., Knibbe, Catherijne A. J., Völler, Swantje

“…Background Doxapram is used for the treatment of apnea of prematurity in dosing regimens only based on bodyweight, as pharmacokinetic data are limited. This…”
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