Search Results - "Allday, M J"

Two Epstein-Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma by Anderton, E, Yee, J, Smith, P, Crook, T, White, R E, Allday, M J

“…Epstein–Barr virus (EBV) contributes to the development of several human cancers including the endemic form of Burkitt's lymphoma (BL). In culture, EBV induces…”
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A common polymorphism acts as an intragenic modifier of mutant p53 behaviour by Kaelin, William G, Marin, Maria Carmen, Jost, Christine A, Brooks, Louise A, Irwin, Meredith S, O'Nions, Jenny, Tidy, John A, James, Nick, McGregor, Jane M, Harwood, Catherine A, Yulug, Isik G, Vousden, Karen H, Allday, Martin J, Gusterson, Barry, Ikawa, Shuntaro, Hinds, Philip W, Crook, Tim

“…The p73 protein, a homologue of the tumour-suppressor protein p53, can activate p53-responsive promoters and induce apoptosis in p53-deficient cells. Here we…”
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Epstein-Barr virus nuclear antigen (EBNA)3C is an immortalizing oncoprotein with similar properties to adenovirus E1A and papillomavirus E7 by Parker, G A, Crook, T, Bain, M, Sara, E A, Farrell, P J, Allday, M J

“…Epstein-Barr virus (EBV) requires six genes to efficiently immortalize human B cells. We have shown that one of these, EBNA3C, can cooperate with activated…”
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Physical and Functional Interactions between the Corepressor CtBP and the Epstein-Barr Virus Nuclear Antigen EBNA3C by Touitou, R, Hickabottom, M, Parker, G, Crook, T, Allday, M J

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Epstein-Barr virus EBNA3C can disrupt multiple cell cycle checkpoints and induce nuclear division divorced from cytokinesis by PARKER, G. A, TOUITOU, R, ALLDAY, M. J

“…Expression of EBNA3C is essential for the immortalization of B cells by EBV in vitro and, in co-operation with activated ras, EBNA3C has oncogenic activity in…”
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Epstein-Barr virus nuclear antigen EBNA3C/6 expression maintains the level of latent membrane protein 1 in G1-arrested cells by ALLDAY, M. J, FARRELL, P. J

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TGF-β induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-XL by Spender, L C, O'Brien, D I, Simpson, D, Dutt, D, Gregory, C D, Allday, M J, Clark, L J, Inman, G J

“…Transforming growth factor- β (TGF- β ) potently induces apoptosis in Burkitt's lymphoma (BL) cell lines and in explanted primary human B lymphocytes. The…”
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Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions by SMITH, P. D, CROSSLAND, S, CROOK, T, PARKER, G, OSIN, P, BROOKS, L, WALLER, J, PHILP, E, CROMPTON, M. R, GUSTERSON, B. A, ALLDAY, M. J

“…Inheritance of germ-line mutant alleles of BRCA1 and BRCA2 confers a markedly increased risk of breast cancer and we have previously reported a higher…”
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Activators of the Epstein-Barr Virus Lytic Program Concomitantly Induce Apoptosis, but Lytic Gene Expression Protects from Cell Death by Inman, Gareth J., Binné, Ulrich K., Parker, Gillian A., Farrell, Paul J., Allday, Martin J.

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Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21 by Radkov, S A, Bain, M, Farrell, P J, West, M, Rowe, M, Allday, M J

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Epstein--Barr virus (EBV) nuclear antigen 6 induces expression of the EBV latent membrane protein and an activated phenotype in Raji cells by Allday, M. J, Crawford, D. H, Thomas, J. A

“…Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K. Epstein—Barr virus (EBV) nuclear antigen…”
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Epstein-Barr Virus Latent Gene Expression during the Initiation of B Cell Immortalization by Allday, M. J, Crawford, D. H, Griffin, B. E

“…Department of Virology, Royal Postgraduate Medical School, Du Cane Road, London W12 0NN, U.K. Epstein-Barr virus (EBV) has the capacity to immortalize a…”
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Epstein-Barr virus nuclear antigen 3C is a powerful repressor of transcription when tethered to DNA by Bain, M, Watson, R J, Farrell, P J, Allday, M J

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EBV gene expression in an NPC‐related tumour by Hitt, M.M., Allday, M.J., Hara, T., Karran, L., Jones, M.D., Busson, P., Tursz, T., Ernberg, I., Griffin, B.E.

“…A nasopharyngeal carcinoma tumour (designated C15) propagated in nude mice has been used to generate a large cDNA library that we have analysed for…”
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Role of epithelium in EBV persistence and pathogenesis of B-cell tumours by Allday, M J, Crawford, D H

“…EBV has long been thought to be primarily a B-lymphotropic virus. A manifestation of this tropism is the association of the virus with a variety of B-cell…”
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A transforming p53 mutant, which binds DNA, transactivates and induces apoptosis reveals a nuclear:cytoplasmic shuttling defect by CROOK, T, PARKER, G. A, ROZYCKA, M, CROSSLAND, S, ALLDAY, M. J

“…The DG75 Burkitt lymphoma-derived human B cell line is heterozygous for p53, carrying wild type (WT) and mutant (Arg283His) alleles. The cells constitutively…”
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High level expression of ΔN-p63 : a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)? by CROOK, T, NICHOLLS, J. M, BROOKS, L, O'NIONS, J, ALLDAY, M. J

“…Undifferentiated nasopharyngeal carcinoma (NPC) is an epithelial malignancy that is consistently associated with Epstein-Barr virus (EBV) but which very rarely…”
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Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent by Inman, G J, Allday, M J

“…TGF-beta is a potent inducer of apoptosis in many Burkitt's lymphoma (BL) cell lines. In this study, we characterize this apoptotic process in the EBV-negative…”
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Epstein-Barr virus suppresses a G(2)/M checkpoint activated by genotoxins by Wade, M, Allday, M J

“…Several Epstein-Barr virus (EBV)-negative Burkitt lymphoma-derived cell lines (for example, BL41 and Ramos) are extremely sensitive to genotoxic drugs despite…”
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CpG methylation of viral DNA in EBV-associated tumours by Allday, M J, Kundu, D, Finerty, S, Griffin, B E

“…In EBV-immortalized lymphoblastoid cell lines (LCLs) a small number of "latent" proteins are expressed. These are the EBV nuclear antigens, EBNAs 1-6, and a…”
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