Search Results - "Allcock, Robert W"

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules by Andrews, Paul D, Becroft, Melissa, Aspegren, Anders, Gilmour, Jane, James, Martyn J, McRae, Scott, Kime, Robert, Allcock, Robert W, Abraham, Achamma, Jiang, Zhong, Strehl, Raimund, Mountford, Joanne C, Milligan, Graeme, Houslay, Miles D, Adams, David R, Frearson, Julie A

“…The propensity of human embryonic stem cells to die upon enzymatic disaggregation or low-density plating is an obstacle to their isolation and routine use in…”
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Phosphodiesterase inhibitors. Part 1: Synthesis and structure–activity relationships of pyrazolopyridine–pyridazinone PDE inhibitors developed from ibudilast by Allcock, Robert W., Blakli, Haakon, Jiang, Zhong, Johnston, Karen A., Morgan, Keith M., Rosair, Georgina M., Iwase, Kazuhiko, Kohno, Yasushi, Adams, David R.

“…Ibudilast [1-(2-isopropylpyrazolo[1,5- a]pyridin-3-yl)-2-methylpropan-1-one] is a nonselective phosphodiesterase inhibitor used clinically to treat asthma…”
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Elucidation of a Structural Basis for the Inhibitor-Driven, p62 (SQSTM1)-Dependent Intracellular Redistribution of cAMP Phosphodiesterase-4A4 (PDE4A4) by Day, Jonathan P, Lindsay, Barbara, Riddell, Tracy, Jiang, Zhong, Allcock, Robert W, Abraham, Achamma, Sookup, Sebastian, Christian, Frank, Bogum, Jana, Martin, Elisabeth K, Rae, Robert L, Anthony, Diana, Rosair, Georgina M, Houslay, Daniel M, Huston, Elaine, Baillie, George S, Klussmann, Enno, Houslay, Miles D, Adams, David R

“…A survey of PDE4 inhibitors reveals that some compounds trigger intracellular aggregation of PDE4A4 into accretion foci through association with the…”
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Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases by Omar, Faisa, Findlay, Jane E., Carfray, Gemma, Allcock, Robert W., Jiang, Zhong, Moore, Caitlin, Muir, Amy L., Lannoy, Morgane, Fertig, Bracy A., Mai, Deborah, Day, Jonathan P., Bolger, Graeme, Baillie, George S., Schwiebert, Erik, Klussmann, Enno, Pyne, Nigel J., Ong, Albert C. M., Bowers, Keith, Adam, Julia M., Adams, David R., Houslay, Miles D., Henderson, David J. P.

“…Cyclic AMP (cAMP) phosphodiesterase-4 (PDE4) enzymes degrade cAMP and underpin the compartmentalization of cAMP signaling through their targeting to particular…”
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Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells by Burton, Peter, Adams, David R, Abraham, Achamma, Allcock, Robert W, Jiang, Zhong, McCahill, Angela, Gilmour, Jane, McAbney, John, Kaupisch, Alexandra, Kane, Nicole M, Baillie, George S, Baker, Andrew H, Milligan, Graeme, Houslay, Miles D, Mountford, Joanne C

“…hESCs (human embryonic stem cells) have enormous potential for use in pharmaceutical development and therapeutics; however, to realize this potential, there is…”
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Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells by Burton, Peter, Adams, David R, Abraham, Achamma, Allcock, Robert W, Jiang, Zhong, McCahill, Angela, Gilmour, Jane, McAbney, John, Kane, Nicole M, Baillie, George S, McKenzie, Fergus R, Baker, Andrew H, Houslay, Miles D, Mountford, Joanne C, Milligan, Graeme

“…hESCs (human embryonic stem cells) offer great potential for pharmaceutical research and development and, potentially, for therapeutic use. However,…”
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Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure–activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity by Ochiai, Koji, Takita, Satoshi, Eiraku, Tomohiko, Kojima, Akihiko, Iwase, Kazuhiko, Kishi, Tetsuya, Fukuchi, Kazunori, Yasue, Tokutaro, Adams, David R., Allcock, Robert W., Jiang, Zhong, Kohno, Yasushi

“…(−)-6-(7-Methoxy-2-trifluoromethylpyrazolo[1,5-a]pyridin-4-yl)-5-methyl-4,5-dihydro-3-(2H)-pyridazinone (KCA-1490) is a dual PDE3/4 inhibitor that exhibits…”
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Novel synthetic approaches to the palmarumycin skeleton by Coutts, Ian G.C, Allcock, Robert W, Scheeren, Hans W

“…Oxidation of readily available aminonaphthols 7a and 7b with activated manganese dioxide gives palmarumycin analogues 8a and 8b in good yield. The related…”
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Concise routes to pyrazolo[1,5-a]pyridin-3-yl pyridazin-3-ones by Johnston, Karen A, Allcock, Robert W, Jiang, Zhong, Collier, Ian D, Blakli, Haakon, Rosair, Georgina M, Bailey, Patrick D, Morgan, Keith M, Kohno, Yasushi, Adams, David R

“…Cycloaddition of pyridine N-imine with 6-alkyl-4-oxohex-5-ynoates followed by condensation with hydrazine provides concise access to pharmacologically active…”
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