Search Results - "Allay, E"

Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo by PERSONS, D. A, ALLAY, J. A, ALLAY, E. R, SMEYNE, R. J, ASHMUN, R. A, SORRENTINO, B. P, NIENHUIS, A. W

“…We have investigated the utility of the green fluorescent protein (GFP) to serve as a marker to assess retroviral gene transfer into hematopoietic cells and as…”
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Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis by PERSONS, D. A, ALLAY, J. A, ALLAY, E. R, ASHMUN, R. A, ORLIC, D, JANE, S. M, CUNNINGHAM, J. M, NIENHUIS, A. W

“…The zinc finger transcription factor GATA-2 is highly expressed in immature hematopoietic cells and declines with blood cell maturation. To investigate its…”
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Functional requirements for phenotypic correction of murine β-thalassemia: implications for human gene therapy by Persons, Derek A., Allay, Esther R., Sabatino, Denise E., Kelly, Patrick, Bodine, David M., Nienhuis, Arthur W.

“…As initial human gene therapy trials for β-thalassemia are contemplated, 2 critical questions important to trial design and planning have emerged. First, what…”
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Determinants of O6-alkylguanine-DNA alkyltransferase activity in human colon cancer by GERSON, S. L, ALLAY, E, VITANTONIO, K, DUMENCO, L. L

“…The DNA repair protein O6-alkylguanine-DNA alkyltransferase (alkyltransferase) repairs cytotoxic DNA O6-alkylguanine adducts induced by the nitrosoureas,…”
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The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase by DUMENCO, L. L, ALLAY, E, NORTON, K, GERSON, S. L

“…Nitrosoureas form O6-alkylguanine-DNA adducts that are converted to G to A transitions, the mutation found in the activated ras oncogenes of…”
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Overexpression of human O super(6)-alkylguanine DNA alkyltransferase (AGT) prevents MNU induced lymphomas in heterozygous p53 deficient mice by Reese, J S, Allay, E, Gerson, S L

“…O super(6)-alkylguanine DNA alkyltransferase (AGT) is a key mechanism in the prevention against MNU induced malignant transformation by removal of O super(6)…”
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Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea by Allay, E, Veigl, M, Gerson, S L

“…While it is well known that MNU induces thymic lymphomas in the mouse, it remains unclear which pre-mutagenic lesions are responsible for lymphomagenic…”
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Mice over-expressing human O super(6)alkylguanine-DNA alkyltransferase selectively reduce O super(6)methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea by Allay, E, Veigl, M, Gerson, S L

“…While it is well known that MNU induces thymic lymphomas in the mouse, it remains unclear which premutagenic lesions are responsible for lymphomagenic…”
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Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon by Zaidi, N H, Pretlow, T P, O'Riordan, M A, Dumenco, L L, Allay, E, Gerson, S L

“…Transgenic mice over-expressing MGMT, which codes for the human protein O6-alkylguanine-DNA alkyltransferase, are protected from methylating agent-induced…”
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Overexpression of human O6-alkylguanine DNA alkyltransferase (AGT) prevents MNU induced lymphomas in heterozygous p53 deficient mice by REESE, J. S, ALLAY, E, GERSON, S. L

“…O6-alkylguanine DNA alkyltransferase (AGT) is a key mechanism in the prevention against MNU induced malignant transformation by removal of O6 methyl guanine…”
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The degree of phenotypic correction of murine β-thalassemia intermedia following lentiviral-mediated transfer of a human γ-globin gene is influenced by chromosomal position effects and vector copy number by Persons, Derek A., Hargrove, Phillip W., Allay, Esther R., Hanawa, Hideki, Nienhuis, Arthur W.

“…Increased fetal hemoglobin (HbF) levels diminish the clinical severity of β-thalassemia and sickle cell anemia. A treatment strategy using autologous stem…”
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Successful treatment of murine β-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells by Persons, Derek A., Allay, Esther R., Sawai, Nobukuni, Hargrove, Phillip W., Brent, Thomas P., Hanawa, Hideki, Nienhuis, Arthur W., Sorrentino, Brian P.

“…Successful gene therapy of β-thalassemia will require replacement of the abnormal erythroid compartment with erythropoiesis derived from genetically corrected,…”
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Mice over-expressing human O6alkylguanine-DNA alkyltransferase selectively reduce O6methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea by ALLAY, E, VEIGL, M, GERSON, S. L

“…While it is well known that MNU induces thymic lymphomas in the mouse, it remains unclear which pre-mutagenic lesions are responsible for lymphomagenic…”
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Enforced Expression of the GATA-2 Transcription Factor Blocks Normal Hematopoiesis by Persons, Derek A., Allay, James A., Allay, Esther R., Ashmun, Richard A., Orlic, Donald, Jane, Stephen M., Cunningham, John M., Nienhuis, Arthur W.

“…The zinc finger transcription factor GATA-2 is highly expressed in immature hematopoietic cells and declines with blood cell maturation. To investigate its…”
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Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O super(6)-alkylguanine DNA-alkyltransferase by Allay, E, Reese, J S, McGuire, E A, Koc, ON, Sedransk, N, Gerson, S L

“…We evaluated induction of lymphomas by the methylating carcinogen, N-methylnitrosourea [MNU], in transgenic mice expressing both LMO1 and the DNA repair gene,…”
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Rapid repair of O super(6)-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas by Liu, L, Allay, E, Dumenco, L L, Gerson, S L

“…The methylating agent N-methylnitrosourea (MNU) is biased, surprisingly, in its carcinogenic potential toward the mouse thymus. Previous studies have shown…”
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Rapid repair of O6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thyrmic lymphomas by LIU, L, ALLAY, E, DUMENCO, L; L, GERSON, S; L

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Evolutionary divergence of the cytochrome b5 gene of Drosophila by Kula, M E, Allay, E R, Rozek, C E

“…Cytochrome proteins perform a broad spectrum of biological functions ranging from oxidative metabolism to electron transport and are thus essential to all…”
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Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase by ALLAY, E, REESE, J. S, MCGUIRE, E. A, KOC, O. N, SEDRANSK, N, GERSON, S. L

“…We evaluated induction of lymphomas by the methylating carcinogen, N-methylnitrosourea [MNU], in transgenic mice expressing both LMO1 and the DNA repair gene,…”
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The prevention of thymic lymphomas in transgenic mice by human O super(6)-alkylguanine-DNA alkyltransferase by Dumenco, L L, Allay, E, Norton, K, Gerson, S L

“…Nitrosoureas form O super(6)-alkylguanine-DNA adducts that are converted to G to A transitions, the mutation found in the activated ras oncogenes of…”
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