Search Results - "Allard, M F"

Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts by Allard, M F, Schönekess, B O, Henning, S L, English, D R, Lopaschuk, G D

“…The contribution of glycolysis and oxidative metabolism to ATP production was determined in isolated working hypertrophied hearts perfused with Krebs-Henseleit…”
Get full text

Glycolysis and pyruvate oxidation in cardiac hypertrophy—Why so unbalanced? by Leong, H.S., Brownsey, R.W., Kulpa, J.E., Allard, M.F.

“…Cardiac hypertrophy, induced by chronic pressure or volume overload, is associated with abnormalities in energy metabolism as well as characteristic increases…”
Get full text

Heterogeneity of gut capillary transit times and impaired gut oxygen extraction in endotoxemic pigs by Humer, M F, Phang, P T, Friesen, B P, Allard, M F, Goddard, C M, Walley, K R

“…We tested the hypothesis that endotoxin increases the heterogeneity of gut capillary transit times and impairs oxygen extraction. The gut critical oxygen…”
Get more information

Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice by BROUND, Michael J, ASGHARI, Parisa, ALLARD, Michael F, JOHNSON, James D, WAMBOLT, Rich B, BOHUNEK, Lubos, SMITS, Claire, PHILIT, Marjolaine, KIEFFER, Timothy J, LAKATTA, Edward G, BOHELER, Kenneth R, MOORE, Edwin D. W

“…The molecular mechanisms controlling heart function and rhythmicity are incompletely understood. While it is widely accepted that the type 2 ryanodine receptor…”
Get full text

Regulation of myocardial fatty acid oxidation by substrate supply by Longnus, S L, Wambolt, R B, Barr, R L, Lopaschuk, G D, Allard, M F

“…We tested the hypothesis that myocardial substrate supply regulates fatty acid oxidation independent of changes in acetyl-CoA carboxylase (ACC) and…”
Get more information

The c-myc proto-oncogene regulates cardiac development in transgenic mice by JACKSON, T, ALLARD, M. F, SREENAN, C. M, DOSS, L. K, BISHOP, S. P, SWAIN, J. L

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Marginated pool of neutrophils in rabbit lungs by Doerschuk, C M, Allard, M F, Martin, B A, MacKenzie, A, Autor, A P, Hogg, J C

“…The size and location of the marginated pool of neutrophils (PMNs) in rabbit lungs were evaluated, and the rate of exchange of the PMNs with the circulating…”
Get more information

Prolonged leukocyte transit time in coronary microcirculation of endotoxemic pigs by Goddard, C M, Allard, M F, Hogg, J C, Herbertson, M J, Walley, K R

“…We quantified the timing and extent of leukocyte retention by the coronary microcirculation in a pig model of hyperdynamic sepsis in three ways. First, the…”
Get full text

Contribution of glycogen to aerobic myocardial glucose utilization by HENNING, S. L, WAMBOLT, R. B, SCHÖNEKESS, B. O, LOPASCHUK, G. D, ALLARD, M. F

“…We determined glycogen turnover and the contribution of glycogen as a source of glucose for aerobic myocardial glycolysis and glucose oxidation in parallel…”
Get full text

Propionyl L-Carnitine Improvement of Hypertrophied Heart Function Is Accompanied by an Increase in Carbohydrate Oxidation by Schonekess, Brett O, Allard, Michael F, Lopaschuk, Gary D

“…Propionyl L-carnitine (PLC) is a naturally occurring derivative of L-carnitine that can improve hemodynamic function of hypertrophied rat hearts. The…”
Get full text

Increased Ischemic Injury but Decreased Hypoxic Injury in Hypertrophied Rat Hearts by Anderson, Peter G, Allard, Michael F, Thomas, Gary D, Bishop, Sanford P, Digerness, Stanley B

“…The purpose of this study was to compare the degree of ischemic and hypoxic injury in normal versus hypertrophied rat hearts to investigate basic mechanisms…”
Get full text

Myocardial morphometric changes related to decreased contractility after endotoxin by Goddard, C M, Allard, M F, Hogg, J C, Walley, K R

“…Decreased ventricular contractility during sepsis lasts much longer than the half-lives of inflammatory mediators that have been suggested to be myocardial…”
Get full text

Recovery of glycolysis and oxidative metabolism during postischemic reperfusion of hypertrophied rat hearts by Schönekess, B O, Allard, M F, Lopaschuk, G D

“…We investigated the source and extent of recovery of ATP production during postischemic reperfusion of isolated working hearts from abdominal aortic-banded…”
Get full text

Preischemic glycogen reduction or glycolytic inhibition improves postischemic recovery of hypertrophied rat hearts by Allard, M F, Emanuel, P G, Russell, J A, Bishop, S P, Digerness, S B, Anderson, P G

“…The purpose of this study was to determine whether metabolites produced by glycolysis during ischemia significantly contribute to myocardial injury of…”
Get full text

Leukocytes and decreased left-ventricular contractility during endotoxemia in rabbits by Granton, J T, Goddard, C M, Allard, M F, van Eeden, S, Walley, K R

“…We hypothesized that leukocytes contribute to decreased myocardial contractility following endotoxin infusion. To test this hypothesis, we administered…”
Get more information

Glycogen metabolism in the aerobic hypertrophied rat heart by ALLARD, M. F, HENNING, S. L, WAMBOLT, R. B, GRANLEESE, S. R, ENGLISH, D. R, LOPASCHUK, G. D

“…Rates of glycolysis from exogenous glucose are accelerated in hypertrophied hearts. In this study, we determined whether alterations in the metabolism of…”
Get full text

Neutrophil kinetics in rabbits during infusion of zymosan-activated plasma by Doerschuk, C M, Allard, M F, Hogg, J C

“…Complement activation in vivo produces neutropenia and pulmonary sequestration of neutrophils (PMNs) whereas in vitro activation increases PMN adherence and…”
Get more information

Glycation of Hepatocyte Cytosolic Proteins in Streptozotocin-Induced Diabetic Rats by Gugliucci, A., Allard, M-F.

“…A role for glycation in diabetic pathology appears beyond doubt and one of the present trends is to focus the poorly explored field of intracellular glycation…”
Get full text

Contribution of Glycogen and Exogenous Glucose to Glucose Metabolism During Ischemia in the Hypertrophied Rat Heart by Schonekess, Brett O, Allard, Michael F, Henning, Sarah L, Wambolt, Richard B, Lopaschuk, Gary D

“…Although hypertrophied hearts have increased rates of glycolysis under aerobic conditions, it is controversial as to whether glucose metabolism during ischemia…”
Get full text

Accelerated glycolysis and greater postischemic dysfunction in hypertrophied rat hearts are independent of coronary flow by Wambolt, R B, Grist, M, Bondy, G P, Allard, M F

“…After ischemia, glycolysis and dysfunction are greater, while coupling of glucose oxidation to glycolysis is lower in hypertrophied hearts than in…”
Get more information