Biaxial flexure testing of calcium phosphate bioceramics for use in tissue engineering

Biaxial flexure testing of calcium phosphate bioceramics for use in tissue engineering

This study analyzes data from 206 CaP specimens (68 HA, 70 BCP, and 68 β‐TCP) fractured via biaxial flexure testing. Specimens were divided into four groups: (a) Group I, dry; (b) Group II, wet (day 0, immersion time ∼ 5–10 s); (c) Group III, after immersion in media for 21 days (day 21); and (d) Gr...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A Vol. 72A; no. 1; pp. 115 - 126
Main Authors: Meganck, Jeffrey A., Baumann, Melissa J., Case, Eldon D., McCabe, Laura R., Allar, Jaclyn N.
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-01-2005
Subjects:
Animals
biaxial flexure testing
Calcium Phosphates
Cell Line
Ceramics
Durapatite
grain boundary grooving
hydroxyapatite
Materials Testing
Mechanics
Mice
Microscopy, Electron
Osteoblasts - cytology
slow crack growth
Tissue Engineering
Weibull modulus
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Summary:This study analyzes data from 206 CaP specimens (68 HA, 70 BCP, and 68 β‐TCP) fractured via biaxial flexure testing. Specimens were divided into four groups: (a) Group I, dry; (b) Group II, wet (day 0, immersion time ∼ 5–10 s); (c) Group III, after immersion in media for 21 days (day 21); and (d) Group IV, after culturing osteoblasts (OBs) on the surface for 21 days (day 21 with cells). X‐ray diffraction verified the presence of minor second phases in HA and β‐TCP while BCP was a biphasic mixture of HA and β‐TCP with minor phases present. The statistical significance (p < 0.05) of differences in the measured biaxial flexure fracture strength, S, between groups was assessed via one‐way ANOVA with Tukey's test. Also, a two‐parameter Weibull analysis assessed the mechanical reliability of each group. Osteoblasts increase the biaxial flexure fracture strength in a statistically significant way compared to both the HA discs in Groups II and III. Scanning electron microscope examination revealed grain boundary grooving on the sintered surfaces and with thermal expansion anisotropy, likely leads to the observed rapid strength decline upon exposure to media found in Groups II, III and IV. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 72A: 115–126, 2005
Bibliography:ark:/67375/WNG-3WR7CJ94-J
MSU Foundation
ArticleID:JBM30213
National Science Foundation - No. DMR0074439
istex:A609DE2D3A7E8B28BAE1945FB138483C12D410C2
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.30213