Search Results - "Allan, B J"

Mechanistic Development and Recent Applications of the Chan–Lam Amination by West, Matthew J, Fyfe, James W. B, Vantourout, Julien C, Watson, Allan J. B

“…Transition metal-mediated formation of C–N bonds is an essential synthetic methodology. The discovery of the Chan–Lam amination provided a C–N bond forming…”
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Spectroscopic Studies of the Chan–Lam Amination: A Mechanism-Inspired Solution to Boronic Ester Reactivity by Vantourout, Julien C, Miras, Haralampos N, Isidro-Llobet, Albert, Sproules, Stephen, Watson, Allan J. B

“…We report an investigation of the Chan–Lam amination reaction. A combination of spectroscopy, computational modeling, and crystallography has identified the…”
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Chan–Evans–Lam Amination of Boronic Acid Pinacol (BPin) Esters: Overcoming the Aryl Amine Problem by Vantourout, Julien C, Law, Robert P, Isidro-Llobet, Albert, Atkinson, Stephen J, Watson, Allan J. B

“…The Chan–Evans–Lam reaction is a valuable C–N bond forming process. However, aryl boronic acid pinacol (BPin) ester reagents can be difficult coupling partners…”
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Contra‐Thermodynamic, Photocatalytic E→Z Isomerization of Styrenyl Boron Species: Vectors to Facilitate Exploration of Two‐Dimensional Chemical Space by Molloy, John J., Metternich, Jan B., Daniliuc, Constantin G., Watson, Allan J. B., Gilmour, Ryan

“…Designing strategies to access stereodefined olefinic organoboron species is an important synthetic challenge. Despite significant advances, there is a…”
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Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain by Law, Robert P, Atkinson, Stephen J, Bamborough, Paul, Chung, Chun-wa, Demont, Emmanuel H, Gordon, Laurie J, Lindon, Matthew, Prinjha, Rab K, Watson, Allan J. B, Hirst, David J

“…The bromodomain and extra-terminal domain (BET) family of proteins bind acetylated lysine residues on histone proteins. The four BET bromodomainsBRD2, BRD3,…”
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Mechanism of Cu-Catalyzed Aryl Boronic Acid Halodeboronation Using Electrophilic Halogen: Development of a Base-Catalyzed Iododeboronation for Radiolabeling Applications by Molloy, John J, O’Rourke, Kerry M, Frias, Carolina P, Sloan, Nikki L, West, Matthew J, Pimlott, Sally L, Sutherland, Andrew, Watson, Allan J. B

“…An investigation into the mechanism of Cu-catalyzed aryl boronic acid halodeboronation using electrophilic halogen reagents is reported. Evidence is provided…”
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Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol by Caldwell, Nicola, Jamieson, Craig, Simpson, Iain, Watson, Allan J B

“…A catalytic amidation method has been developed, employing 2,2,2-trifluoroethanol to facilitate condensation of unactivated esters and amines, enabling the…”
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Interrogating Pd(II) Anion Metathesis Using a Bifunctional Chemical Probe: A Transmetalation Switch by Molloy, John J, Seath, Ciaran P, West, Matthew J, McLaughlin, Calum, Fazakerley, Neal J, Kennedy, Alan R, Nelson, David J, Watson, Allan J. B

“…Ligand metathesis of Pd­(II) complexes is mechanistically essential for cross-coupling. We present a study of halide→OH anion metathesis of (Ar)­PdII complexes…”
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Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation by Wilson, Kirsty L, Kennedy, Alan R, Murray, Jane, Greatrex, Ben, Jamieson, Craig, Watson, Allan J B

“…Pd-catalysed C-C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar…”
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Tandem Chemoselective Suzuki-Miyaura Cross-Coupling Enabled by Nucleophile Speciation Control by Seath, Ciaran P., Fyfe, James W. B., Molloy, John J., Watson, Allan J. B.

“…Control of boronic acid speciation is presented as a strategy to achieve nucleophile chemoselectivity in the Suzuki–Miyaura reaction. Combined with…”
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Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature by Castagna, Diana, Budd, David C, Macdonald, Simon J F, Jamieson, Craig, Watson, Allan J B

“…The autotaxin-lysophophatidic acid (ATX-LPA) signaling pathway is implicated in a variety of human disease states including angiogenesis, autoimmune diseases,…”
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A flow platform for degradation-free CuAAC bioconjugation by Hatit, Marine Z. C., Reichenbach, Linus F., Tobin, John M., Vilela, Filipe, Burley, Glenn A., Watson, Allan J. B.

“…The Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a cornerstone method for the ligation of biomolecules. However, undesired Cu-mediated oxidation…”
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Total Synthesis of (±)-Aspidospermidine, (±)-Aspidofractinine, (±)-Limaspermidine, and (±)-Vincadifformine via a Cascade and Common Intermediate Strategy by Cain, David L., Anderson, Niall A., Cordes, David B., Slawin, Alexandra M. Z., Watson, Allan J. B.

“…A concise strategy for the total synthesis of several Aspidosperma alkaloids is reported. A Suzuki–Miyaura cross-coupling provides access to a 2-vinyl indole…”
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Chemoselective Suzuki–Miyaura Cross‐Coupling via Kinetic Transmetallation by Fyfe, James W. B., Fazakerley, Neal J., Watson, Allan J. B.

“…Chemoselective Suzuki–Miyaura cross‐coupling generally requires a designed deactivation of one nucleophile towards transmetallation. Here we show that boronic…”
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Synthesis of 2‑BMIDA Indoles via Heteroannulation: Applications in Drug Scaffold and Natural Product Synthesis by Bell, George E, Fyfe, James W. B, Israel, Eva M, Slawin, Alexandra M. Z, Campbell, Matthew, Watson, Allan J. B

“…A Pd-catalyzed heteroannulation approach for the synthesis of C2 borylated indoles is reported. The process allows access to highly functionalized 2-borylated…”
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Chemoselective Boronic Ester Synthesis by Controlled Speciation by Fyfe, James W. B., Seath, Ciaran P., Watson, Allan J. B.

“…Control of boronic acid solution speciation is presented as a new strategy for the chemoselective synthesis of boronic esters. Manipulation of the solution…”
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Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware by Clohessy, Thomas A, Roberts, Alastair, Manas, Eric S, Patel, Vipulkumar K, Anderson, Niall A, Watson, Allan J. B

“…Functionalized bicyclic amino-azaheterocycles are rapidly accessed in a one-pot cross-coupling/reduction sequence enabled by the use of COware. Incompatible…”
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Strategy for Conditional Orthogonal Sequential CuAAC Reactions Using a Protected Aromatic Ynamine by Hatit, Marine Z. C, Seath, Ciaran P, Watson, Allan J. B, Burley, Glenn A

“…A method for conditional control of orthogonal sequential Cu-catalyzed azide−alkyne cycloaddition (CuAAC) reactions is reported. The inherent reactivity of an…”
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Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators by Keune, Willem-Jan, Potjewyd, Frances, Heidebrecht, Tatjana, Salgado-Polo, Fernando, Macdonald, Simon J. F, Chelvarajan, Lakshman, Abdel Latif, Ahmed, Soman, Sony, Morris, Andrew J, Watson, Allan J. B, Jamieson, Craig, Perrakis, Anastassis

“…Autotaxin produces the bioactive lipid lysophosphatidic acid (LPA) and is a drug target of considerable interest for numerous pathologies. We report the…”
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Catalytic Enantioselective Synthesis of Heterocyclic Vicinal Fluoroamines by Using Asymmetric Protonation: Method Development and Mechanistic Study by Ashford, Matthew W., Xu, Chao, Molloy, John J., Carpenter‐Warren, Cameron, Slawin, Alexandra M. Z., Leach, Andrew G., Watson, Allan J. B.

“…A catalytic enantioselective synthesis of heterocyclic vicinal fluoroamines is reported. A chiral Brønsted acid promotes aza‐Michael addition to fluoroalkenyl…”
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