Search Results - "Allan, Andrea M."

The Effects of Arsenic Exposure on Neurological and Cognitive Dysfunction in Human and Rodent Studies: A Review by Tyler, Christina R., Allan, Andrea M.

“…Arsenic toxicity is a worldwide health concern as several millions of people are exposed to this toxicant via drinking water, and exposure affects almost every…”
Get full text

Adult hippocampal neurogenesis and mRNA expression are altered by perinatal arsenic exposure in mice and restored by brief exposure to enrichment by Tyler, Christina R, Allan, Andrea M

“…Arsenic is a common and pervasive environmental contaminant found in drinking water in varying concentrations depending on region. Exposure to arsenic induces…”
Get full text

Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms by Guo, Weixiang, Polich, Eric D., Su, Juan, Gao, Yu, Christopher, Devin M., Allan, Andrea M., Wang, Min, Wang, Feifei, Wang, Guangfu, Zhao, Xinyu

“…Fragile X mental retardation protein (FMRP) and its autosomal paralog FXR2P are selective neuronal RNA-binding proteins, and mice that lack either protein…”
Get full text

Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning by Guo, Weixiang, Allan, Andrea M, Zong, Ruiting, Zhang, Li, Johnson, Eric B, Schaller, Eric G, Murthy, Adeline C, Goggin, Samantha L, Eisch, Amelia J, Oostra, Ben A, Nelson, David L, Jin, Peng, Zhao, Xinyu

“…Fragile X mental retardation is caused by mutations in the FMRP gene. Now, Xinyu Zhao and her colleagues show that deletion of Fmrp specifically in adult…”
Get full text

Hyperhomocysteinemia leads to exacerbation of ischemic brain damage: Role of GluN2A NMDA receptors by Jindal, Ankur, Rajagopal, Sathyanarayanan, Winter, Lucas, Miller, Joshua W., Jacobsen, Donald W., Brigman, Jonathan, Allan, Andrea M., Paul, Surojit, Poddar, Ranjana

“…Hyperhomocysteinemia has been implicated in several neurodegenerative disorders including ischemic stroke. However, the pathological consequences of ischemic…”
Get full text

Prenatal alcohol exposure alters mRNA expression for stress peptides, glucocorticoid receptor function and immune factors in acutely stressed neonatal brain by Ruffaner-Hanson, Chaselyn D, Fernandez-Oropeza, Annette K, Sun, Melody S, Caldwell, Kevin K, Allan, Andrea M, Savage, Daniel D, Valenzuela, C Fernando, Noor, Shahani, Milligan, Erin D

“…The amygdala, hippocampus and hypothalamus are critical stress regulatory areas that undergo functional maturation for stress responding initially established…”
Get full text

Prenatal alcohol exposure modifies glucocorticoid receptor subcellular distribution in the medial prefrontal cortex and impairs frontal cortex-dependent learning by Allan, Andrea M, Goggin, Samantha L, Caldwell, Kevin K

“…Prenatal alcohol exposure (PAE) has been shown to impair learning, memory and executive functioning in children. Perseveration, or the failure to respond…”
Get full text

A novel method for the normalization of ChIP-qPCR data by Solomon, Elizabeth R, Caldwell, Kevin K, Allan, Andrea M

“…ChIP-qPCR permits the study of protein and chromatin interactions. The general technique can apply to the study of the interactions of protein with RNA, and…”
Get full text

Prenatal alcohol exposure results in brain region- and sex-specific changes in circHomer1 expression in adult mouse brain by Papageorgiou, Grigorios, Amoah, Stephen K, Pierotti, Caroline, Otero, Madison, Eckel, Sophie, Coffey, Kacie, Allan, Andrea M, Caldwell, Kevin K, Mellios, Nikolaos

“…Circular RNAs (circRNAs) are a novel category of covalently-closed non-coding RNAs mainly derived from the back-splicing of exons or introns of protein-coding…”
Get full text

Prenatal Alcohol Exposure Results in Sex-Specific Alterations in Circular RNA Expression in the Developing Mouse Brain by Paudel, Praveen, Pierotti, Caroline, Lozano, Evelyn, Amoah, Stephen K, Gardiner, Amy S, Caldwell, Kevin K, Allan, Andrea M, Mellios, Nikolaos

“…Fetal alcohol spectrum disorders (FASD) are heterogeneous disorders associated with alcohol exposure to the developing fetus that are characterized by a range…”
Get full text

Behavioral Teratogenicity Induced by Nonforced Maternal Nicotine Consumption by PAZ, Rodrigo, BARSNESS, Brigg, MARTENSON, Trevor, TANNER, Daniel, ALLAN, Andrea M

“…Prenatal nicotine exposure (PNE) has been associated with increased prevalence of attention deficit hyperactivity disorder (ADHD), major depressive disorder…”
Get full text

Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia by Deb, Ishani, Manhas, Namratta, Poddar, Ranjana, Rajagopal, Sathyanarayanan, Allan, Andrea M, Lombroso, Paul J, Rosenberg, Gary A, Candelario-Jalil, Eduardo, Paul, Surojit

“…The striatal-enriched phosphatase (STEP) is a component of the NMDA-receptor-mediated excitotoxic signaling pathway, which plays a key role in ischemic brain…”
Get full text

Learning deficits in C57BL/6J mice following perinatal arsenic exposure: Consequence of lower corticosterone receptor levels? by Martinez-Finley, Ebany J., Ali, Abdul-Mehdi S., Allan, Andrea M.

“…Most studies on arsenic as a drinking water contaminant have focused on its carcinogenic potential but a few suggest that arsenic can adversely affect…”
Get full text

Sex-Dependent Effects of the Histone Deacetylase Inhibitor, Sodium Valproate, on Reversal Learning After Developmental Arsenic Exposure by Tyler, Christina R Steadman, Smoake, Jane J W, Solomon, Elizabeth R, Villicana, Estrella, Caldwell, Kevin K, Allan, Andrea M

“…Several studies have demonstrated that exposure to arsenic in drinking water adversely affects brain development and cognitive function in adulthood. While the…”
Get full text

KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization by Olguin, Sarah L., Patel, Priyanka, Buchanan, Courtney N., Dell’Orco, Michela, Gardiner, Amy S., Cole, Robert, Vaughn, Lauren S., Sundararajan, Anitha, Mudge, Joann, Allan, Andrea M., Ortinski, Pavel, Brigman, Jonathan L., Twiss, Jeffery L., Perrone-Bizzozero, Nora I.

“…The KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein linked to decay of mRNAs with AU-rich elements. KHSRP was previously shown to…”
Get full text

Hippocampal N-Methyl-d-Aspartate Receptor Subunit Expression Profiles in a Mouse Model of Prenatal Alcohol Exposure by Samudio-Ruiz, Sabrina L., Allan, Andrea M., Sheema, Sheema, Caldwell, Kevin K.

“…Background:  Although several reports have been published showing prenatal ethanol exposure is associated with alterations in N‐methyl‐d‐aspartate (NMDA)…”
Get full text

Sex-Dependent effects of developmental arsenic exposure on methylation capacity and methylation regulation of the glucocorticoid receptor system in the embryonic mouse brain by Allan, Andrea M, Hafez, Alexander K, Labrecque, Matthew T, Solomon, Elizabeth R, Shaikh, M Nabil, Zheng, Xianyun, Ali, Abdulmehdi

“…Previously we have shown that prenatal moderate arsenic exposure (50 ppb) disrupts glucocorticoid receptor (GR) programming and that these changes continue…”
Get full text

A Mouse Model of Prenatal Ethanol Exposure Using a Voluntary Drinking Paradigm by Allan, Andrea M., Chynoweth, Julie, Tyler, Lani A., Caldwell, Kevin K.

“…Background: The incidence of fetal alcohol spectrum disorders is estimated to be as high as 1 in 100 births. Efforts to better understand the basis of prenatal…”
Get full text

A peptide mimetic of tyrosine phosphatase STEP as a potential therapeutic agent for treatment of cerebral ischemic stroke by Poddar, Ranjana, Rajagopal, Sathyanarayanan, Winter, Lucas, Allan, Andrea M, Paul, Surojit

“…Extensive research over the last two decades has advanced our understanding of the pathophysiology of ischemic stroke. However, current pharmacologic therapies…”
Get full text

MicroRNA‐150‐5p is upregulated in the brain microvasculature during prenatal alcohol exposure and inhibits the angiogenic factor Vezf1 by Perales, Gabriela, Westenskow, Marissa, Gutierrez, Roxana, Caldwell, Kevin K., Allan, Andrea M., Gardiner, Amy S.

“…Background Fetal alcohol spectrum disorders (FASD) occur in children who were exposed to alcohol in utero and are manifested in a wide range of neurocognitive…”
Get full text