Search Results - "Allam, Mayar"

Multiplex bioimaging of single-cell spatial profiles for precision cancer diagnostics and therapeutics by Allam, Mayar, Cai, Shuangyi, Coskun, Ahmet F.

“…Cancers exhibit functional and structural diversity in distinct patients. In this mass, normal and malignant cells create tumor microenvironment that is…”
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Single-cell spatial metabolomics with cell-type specific protein profiling for tissue systems biology by Hu, Thomas, Allam, Mayar, Cai, Shuangyi, Henderson, Walter, Yueh, Brian, Garipcan, Aybuke, Ievlev, Anton V., Afkarian, Maryam, Beyaz, Semir, Coskun, Ahmet F.

“…Metabolic reprogramming in cancer and immune cells occurs to support their increasing energy needs in biological tissues. Here we propose Single Cell Spatially…”
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COVID-19 Diagnostics, Tools, and Prevention by Allam, Mayar, Cai, Shuangyi, Ganesh, Shambavi, Venkatesan, Mythreye, Doodhwala, Saurabh, Song, Zexing, Hu, Thomas, Kumar, Aditi, Heit, Jeremy, Study Group, Covid, Coskun, Ahmet F

“…The Coronavirus Disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), outbreak from Wuhan City, Hubei province,…”
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Spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease by Allam, Mayar, Hu, Thomas, Cai, Shuangyi, Laxminarayanan, Krishnan, Hughley, Robert B., Coskun, Ahmet F.

“…Deep molecular profiling of biological tissues is an indicator of health and disease. We used imaging mass cytometry (IMC) to acquire spatially resolved…”
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Spatially variant immune infiltration scoring in human cancer tissues by Allam, Mayar, Hu, Thomas, Lee, Jeongjin, Aldrich, Jeffrey, Badve, Sunil S., Gökmen-Polar, Yesim, Bhave, Manali, Ramalingam, Suresh S., Schneider, Frank, Coskun, Ahmet F.

“…The Immunoscore is a method to quantify the immune cell infiltration within cancers to predict the disease prognosis. Previous immune profiling approaches…”
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The Role of Desmoplasia and Stromal Fibroblasts on Anti-cancer Drug Resistance in a Microengineered Tumor Model by Saini, Harpinder, Rahmani Eliato, Kiarash, Silva, Casey, Allam, Mayar, Mouneimne, Ghassan, Ros, Robert, Nikkhah, Mehdi

“…Introduction Cancer associated fibroblasts (CAFs) are known to participate in anti-cancer drug resistance by upregulating desmoplasia and pro-survival…”
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Multiplexed protein profiling reveals spatial subcellular signaling networks by Cai, Shuangyi, Hu, Thomas, Venkatesan, Mythreye, Allam, Mayar, Schneider, Frank, Ramalingam, Suresh S., Sun, Shi-Yong, Coskun, Ahmet F.

“…Protein-protein interaction networks are altered in multi-gene dysregulations in many disorders. Image-based protein multiplexing sheds light on signaling…”
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Combining spatial metabolomics and proteomics profiling of single cells by Allam, Mayar, Coskun, Ahmet F.

“…In this Tools of the Trade article, Mayar Allam and Ahmet Coskun describe how they combined spatial metabolomics and proteomics profiling — in a framework they…”
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Single-Cell and Spatial Analysis of Emergent Organoid Platforms by Kumar, Aditi, Cai, Shuangyi, Allam, Mayar, Henderson, Samuel, Ozbeyler, Melissa, Saiontz, Lilly, Coskun, Ahmet F

“…Organoids have emerged as a promising advancement of the two-dimensional (2D) culture systems to improve studies in organogenesis, drug discovery, precision…”
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The role of tumor-stroma interactions on desmoplasia and tumorigenicity within a microengineered 3D platform by Saini, Harpinder, Rahmani Eliato, Kiarash, Veldhuizen, Jaimeson, Zare, Azadeh, Allam, Mayar, Silva, Casey, Kratz, Alex, Truong, Danh, Mouneimne, Ghassan, LaBaer, Joshua, Ros, Robert, Nikkhah, Mehdi

“…The tumor microenvironment has been demonstrated to play a crucial role in modulating cancer progression. Amongst various cell types within the tumor…”
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Spatial immunophenotyping using multiplexed imaging of immune follicles in secondary lymphoid tissues by Allam, Mayar, Hu, Thomas, Fang, Zhou, Pi, Michelle, Singh, Ankur, Coskun, Ahmet F

“…Secondary lymphoid organs (SLOs), including tonsils (TS), lymph nodes (LN), and Peyer's Patches, exhibit complementary immune functions. However, little is…”
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Multiplex bioimaging of single-cell spatial profiles for precision cancer diagnostics and therapeutics by Allam, Mayar, Cai, Shuangyi, Coskun, Ahmet F

“…Cancers exhibit functional and structural diversity in distinct patients. In this mass, normal and malignant cells create tumor microenvironment that is…”
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Abstract PO5-23-09: Metabolic alterations in Estrogen Receptor-positive breast cancer contributing to CDK4/6 resistance by Allam, Mayar, Coskun, Ahmet, Hu, Thomas, Gu, Yuan, Badve, Sunil, Gokmen-Polar, Yesim

“…Abstract Background CDK4/6 inhibitors (CDK4/6i) are potent FDA-approved agents for the treatment of metastatic and for high-risk early estrogen receptor…”
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Spatially resolved 3D metabolomic profiling in tissues by Ganesh, Shambavi, Hu, Thomas, Woods, Eric, Allam, Mayar, Cai, Shuangyi, Henderson, Walter, Coskun, Ahmet F

“…Spatially resolved RNA and protein molecular analyses have revealed unexpected heterogeneity of cells. Metabolic analysis of individual cells complements these…”
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Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas by Shah, Shivem B., Carlson, Christopher R., Lai, Kristine, Zhong, Zhe, Marsico, Grazia, Lee, Katherine M., Félix Vélez, Nicole E., Abeles, Elisabeth B., Allam, Mayar, Hu, Thomas, Walter, Lauren D., Martin, Karen E., Gandhi, Khanjan, Butler, Scott D., Puri, Rishi, McCleary-Wheeler, Angela L., Tam, Wayne, Elemento, Olivier, Takata, Katsuyoshi, Steidl, Christian, Scott, David W., Fontan, Lorena, Ueno, Hideki, Cosgrove, Benjamin D., Inghirami, Giorgio, García, Andrés J., Coskun, Ahmet F., Koff, Jean L., Melnick, Ari, Singh, Ankur

“…Activated B-cell-like diffuse large B-cell lymphomas (ABC-DLBCLs) are characterized by constitutive activation of nuclear factor κB driven by the B-cell…”
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Human immune organoids to decode B cell response in healthy donors and patients with lymphoma by Zhong, Zhe, Quiñones-Pérez, Manuel, Dai, Zhonghao, Juarez, Valeria M., Bhatia, Eshant, Carlson, Christopher R., Shah, Shivem B., Patel, Anjali, Fang, Zhou, Hu, Thomas, Allam, Mayar, Hicks, Sakeenah L., Gupta, Mansi, Gupta, Sneh Lata, Weeks, Ethan, Vagelos, Stephanie D., Molina, Alejandro, Mulero-Russe, Adriana, Mora-Boza, Ana, Joshi, Devyani J., Sekaly, Rafick P., Sulchek, Todd, Goudy, Steven L., Wrammert, Jens, Roy, Krishnendu, Boss, Jeremy M., Coskun, Ahmet F., Scharer, Christopher D., García, Andrés J., Koff, Jean L., Singh, Ankur

“…Antibodies are produced when naive B cells differentiate into plasma cells within germinal centres (GCs) of lymphoid tissues. Patients with B cell lymphoma on…”
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Development of Machine Learning Regression Model for COVID-19 Drug Target Prediction by Zamitalo, Alexandra, Xie, Qingtong, Allam, Mayar, Philip, Phinu, Shi, Wenqi, Giuste, Felipe, Marteau, Benoit, Murakoso, Mio, Wang, May D.

“…There is a perennial need to identify novel, effective therapeutic agents to combat rising infections. Recently, prediction of therapeutic targets to decrease…”
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