Search Results - "Allain, H"

Structural basis of the non-coding RNA RsmZ acting as a protein sponge by Duss, Olivier, Michel, Erich, Yulikov, Maxim, Schubert, Mario, Jeschke, Gunnar, Allain, Frédéric H.-T.

“…MicroRNA and protein sequestration by non-coding RNAs (ncRNAs) has recently generated much interest. In the bacterial Csr/Rsm system, which is considered to be…”
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Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA by Theler, Dominik, Dominguez, Cyril, Blatter, Markus, Boudet, Julien, Allain, Frédéric H-T

“…N(6)A methylation is the most abundant RNA modification occurring within messenger RNA. Impairment of methylase or demethylase functions are associated with…”
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RNA‐PROTACs: Degraders of RNA‐Binding Proteins by Ghidini, Alice, Cléry, Antoine, Halloy, François, Allain, Frédéric H. T., Hall, Jonathan

“…Defects in the functions of RNA binding proteins (RBPs) are at the origin of many diseases; however, targeting RBPs with conventional drugs has proven…”
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RNA recognition by double-stranded RNA binding domains: a matter of shape and sequence by Masliah, Grégoire, Barraud, Pierre, Allain, Frédéric H. -T.

“…The double-stranded RNA binding domain (dsRBD) is a small protein domain of 65–70 amino acids adopting an αβββα fold, whose central property is to bind to…”
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SRSF1-Regulated Alternative Splicing in Breast Cancer by Anczuków, Olga, Akerman, Martin, Cléry, Antoine, Wu, Jie, Shen, Chen, Shirole, Nitin H., Raimer, Amanda, Sun, Shuying, Jensen, Mads A., Hua, Yimin, Allain, Frédéric H.-T., Krainer, Adrian R.

“…Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression promotes transformation of mammary cells. Using RNA-seq, we identified…”
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Structural basis of a small molecule targeting RNA for a specific splicing correction by Campagne, Sébastien, Boigner, Sarah, Rüdisser, Simon, Moursy, Ahmed, Gillioz, Laurent, Knörlein, Anna, Hall, Jonathan, Ratni, Hasane, Cléry, Antoine, Allain, Frédéric H.-T.

“…Splicing modifiers promoting SMN2 exon 7 inclusion have the potential to treat spinal muscular atrophy, the leading genetic cause of infantile death. These…”
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Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation by Afroz, Tariq, Hock, Eva-Maria, Ernst, Patrick, Foglieni, Chiara, Jambeau, Melanie, Gilhespy, Larissa A. B., Laferriere, Florent, Maniecka, Zuzanna, Plückthun, Andreas, Mittl, Peer, Paganetti, Paolo, Allain, Frédéric H. T., Polymenidou, Magdalini

“…TDP-43 is a primarily nuclear RNA-binding protein, whose abnormal phosphorylation and cytoplasmic aggregation characterizes affected neurons in patients with…”
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Gac/Rsm signal transduction pathway of γ-proteobacteria: from RNA recognition to regulation of social behaviour by Lapouge, Karine, Schubert, Mario, Allain, Frédéric H.-T, Haas, Dieter

“…In many γ-proteobacteria, the conserved GacS/GacA (BarA/UvrY) two-component system positively controls the expression of one to five genes specifying small…”
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The YTH Domain Is a Novel RNA Binding Domain by Zhang, Zhaiyi, Theler, Dominik, Kaminska, Katarzyna H., Hiller, Michael, de la Grange, Pierre, Pudimat, Rainer, Rafalska, Ilona, Heinrich, Bettina, Bujnicki, Janusz M., Allain, Frédéric H.-T., Stamm, Stefan

“…The YTH (YT521-B homology) domain was identified by sequence comparison and is found in 174 different proteins expressed in eukaryotes. It is characterized by…”
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Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation by Mayer, Daniel, Damberger, Fred F., Samarasimhareddy, Mamidi, Feldmueller, Miki, Vuckovic, Ziva, Flock, Tilman, Bauer, Brian, Mutt, Eshita, Zosel, Franziska, Allain, Frédéric H. T., Standfuss, Jörg, Schertler, Gebhard F. X., Deupi, Xavier, Sommer, Martha E., Hurevich, Mattan, Friedler, Assaf, Veprintsev, Dmitry B.

“…Cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind…”
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Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8 by Pröpster, Johannes M., Yang, Fan, Rabbani, Said, Ernst, Beat, Allain, Frédéric H.-T., Schubert, Mario

“…Siglec-8 is a human immune-inhibitory receptor that, when engaged by specific self-glycans, triggers eosinophil apoptosis and inhibits mast cell degranulation,…”
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Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43 by Lukavsky, Peter J, Daujotyte, Dalia, Tollervey, James R, Ule, Jernej, Stuani, Cristiana, Buratti, Emanuele, Baralle, Francisco E, Damberger, Fred F, Allain, Frédéric H-T

“…TDP-43 regulates alternative splicing of the cystic fibrosis transmembrane regulator (CFTR) and is found in cytosolic granules associated with several…”
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Non-specific adhesive forces between filaments and membraneless organelles by Böddeker, Thomas J., Rosowski, Kathryn A., Berchtold, Doris, Emmanouilidis, Leonidas, Han, Yaning, Allain, Frédéric H. T., Style, Robert W., Pelkmans, Lucas, Dufresne, Eric R.

“…Many membraneless organelles are liquid-like domains that form inside the active, viscoelastic environment of living cells through phase separation. To…”
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Sequence-specific binding of single-stranded RNA: is there a code for recognition by Auweter, Sigrid D, Oberstrass, Florian C, Allain, Frédéric H.-T

“…A code predicting the RNA sequence that will be bound by a certain protein based on its amino acid sequence or its structure would provide a useful tool for…”
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The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity by Loughlin, Fionna E., Lukavsky, Peter J., Kazeeva, Tamara, Reber, Stefan, Hock, Eva-Maria, Colombo, Martino, Von Schroetter, Christine, Pauli, Phillip, Cléry, Antoine, Mühlemann, Oliver, Polymenidou, Magdalini, Ruepp, Marc-David, Allain, Frédéric H.-T.

“…Fused in sarcoma (FUS) is an RNA binding protein involved in regulating many aspects of RNA processing and linked to several neurodegenerative diseases…”
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Structural basis for Cas9 off-target activity by Pacesa, Martin, Lin, Chun-Han, Cléry, Antoine, Saha, Aakash, Arantes, Pablo R, Bargsten, Katja, Irby, Matthew J, Allain, Frédéric H-T, Palermo, Giulia, Cameron, Peter, Donohoue, Paul D, Jinek, Martin

“…The target DNA specificity of the CRISPR-associated genome editor nuclease Cas9 is determined by complementarity to a 20-nucleotide segment in its guide RNA…”
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Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers by Sivaramakrishnan, Manaswini, McCarthy, Kathleen D., Campagne, Sébastien, Huber, Sylwia, Meier, Sonja, Augustin, Angélique, Heckel, Tobias, Meistermann, Hélène, Hug, Melanie N., Birrer, Pascale, Moursy, Ahmed, Khawaja, Sarah, Schmucki, Roland, Berntenis, Nikos, Giroud, Nicolas, Golling, Sabrina, Tzouros, Manuel, Banfai, Balazs, Duran-Pacheco, Gonzalo, Lamerz, Jens, Hsiu Liu, Ying, Luebbers, Thomas, Ratni, Hasane, Ebeling, Martin, Cléry, Antoine, Paushkin, Sergey, Krainer, Adrian R., Allain, Frédéric H.-T., Metzger, Friedrich

“…Small molecule splicing modifiers have been previously described that target the general splicing machinery and thus have low specificity for individual genes…”
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Specific inhibition of splicing factor activity by decoy RNA oligonucleotides by Denichenko, Polina, Mogilevsky, Maxim, Cléry, Antoine, Welte, Thomas, Biran, Jakob, Shimshon, Odelia, Barnabas, Georgina D., Danan-Gotthold, Miri, Kumar, Saran, Yavin, Eylon, Levanon, Erez Y., Allain, Frédéric H., Geiger, Tamar, Levkowitz, Gil, Karni, Rotem

“…Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up- or…”
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Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM by Ripin, Nina, Boudet, Julien, Duszczyk, Malgorzata M., Hinniger, Alexandra, Faller, Michael, Krepl, Miroslav, Gadi, Abhilash, Schneider, Robert J., Šponer, Jiří, Meisner-Kober, Nicole C., Allain, Frédéric H.-T.

“…Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate–rich elements (AU-rich elements; AREs). These are a major class of…”
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NMR and EPR reveal a compaction of the RNA-binding protein FUS upon droplet formation by Emmanouilidis, Leonidas, Esteban-Hofer, Laura, Damberger, Fred F., de Vries, Tebbe, Nguyen, Cristina K. X., Ibáñez, Luis Fábregas, Mergenthal, Simon, Klotzsch, Enrico, Yulikov, Maxim, Jeschke, Gunnar, Allain, Frédéric H.-T.

“…Many RNA-binding proteins undergo liquid–liquid phase separation, which underlies the formation of membraneless organelles, such as stress granules and…”
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