Search Results - "Allain, Frederic H‐T"

Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa by Sonnleitner, Elisabeth, Wulf, Alexander, Campagne, Sébastien, Pei, Xue-Yuan, Wolfinger, Michael T, Forlani, Giada, Prindl, Konstantin, Abdou, Laetitia, Resch, Armin, Allain, Frederic H -T, Luisi, Ben F, Urlaub, Henning, Bläsi, Udo

“…Abstract In Pseudomonas aeruginosa the RNA chaperone Hfq and the catabolite repression control protein (Crc) act as post-transcriptional regulators during…”
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Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2 by Schütz, Sabina, Michel, Erich, Damberger, Fred F., Oplová, Michaela, Peña, Cohue, Leitner, Alexander, Aebersold, Ruedi, Allain, Frederic H.-T., Panse, Vikram Govind

“…Disordered extensions at the termini and short internal insertions distinguish eukaryotic ribosomal proteins (r-proteins) from their anucleated archaeal…”
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Orthogonal Tyrosine and Cysteine Site-Directed Spin Labeling for Dipolar Pulse EPR Spectroscopy on Proteins by Gmeiner, Christoph, Klose, Daniel, Mileo, Elisabetta, Belle, Valérie, Marque, Sylvain R. A, Dorn, Georg, Allain, Frédéric H. T, Guigliarelli, Bruno, Jeschke, Gunnar, Yulikov, Maxim

“…Site-directed spin labeling of native tyrosine residues in isolated domains of the protein PTBP1, using a Mannich-type reaction, was combined with conventional…”
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Systematic Identification of Protein–Metabolite Interactions in Complex Metabolite Mixtures by Ligand-Detected Nuclear Magnetic Resonance Spectroscopy by Nikolaev, Yaroslav V, Kochanowski, Karl, Link, Hannes, Sauer, Uwe, Allain, Frederic H.-T

“…Protein–metabolite interactions play a vital role in the regulation of numerous cellular processes. Consequently, identifying such interactions is a key…”
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Prokaryotic ubiquitin-like protein remains intrinsically disordered when covalently attached to proteasomal target proteins by Barandun, Jonas, Damberger, Fred F, Delley, Cyrille L, Laederach, Juerg, Allain, Frédéric H T, Weber-Ban, Eilika

“…The post-translational modification pathway referred to as pupylation marks proteins for proteasomal degradation in Mycobacterium tuberculosis and other…”
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SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition by Kim, Eunhee, Ilagan, Janine O., Liang, Yang, Daubner, Gerrit M., Lee, Stanley C.-W., Ramakrishnan, Aravind, Li, Yue, Chung, Young Rock, Micol, Jean-Baptiste, Murphy, Michele E., Cho, Hana, Kim, Min-Kyung, Zebari, Ahmad S., Aumann, Shlomzion, Park, Christopher Y., Buonamici, Silvia, Smith, Peter G., Deeg, H. Joachim, Lobry, Camille, Aifantis, Iannis, Modis, Yorgo, Allain, Frederic H.-T., Halene, Stephanie, Bradley, Robert K., Abdel-Wahab, Omar

“…Mutations affecting spliceosomal proteins are the most common mutations in patients with myelodysplastic syndromes (MDS), but their role in MDS pathogenesis…”
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Loss of TDP‐43 oligomerization or RNA binding elicits distinct aggregation patterns by Pérez‐Berlanga, Manuela, Wiersma, Vera I, Zbinden, Aurélie, De Vos, Laura, Wagner, Ulrich, Foglieni, Chiara, Mallona, Izaskun, Betz, Katharina M, Cléry, Antoine, Weber, Julien, Guo, Zhongning, Rigort, Ruben, de Rossi, Pierre, Manglunia, Ruchi, Tantardini, Elena, Sahadevan, Sonu, Stach, Oliver, Hruska‐Plochan, Marian, Allain, Frederic H‐T, Paganetti, Paolo, Polymenidou, Magdalini

“…Aggregation of the RNA‐binding protein TAR DNA‐binding protein 43 (TDP‐43) is the key neuropathological feature of neurodegenerative diseases, including…”
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Structural basis of siRNA recognition by TRBP double‐stranded RNA binding domains by Masliah, Gregoire, Maris, Christophe, König, Sebastian LB, Yulikov, Maxim, Aeschimann, Florian, Malinowska, Anna L, Mabille, Julie, Weiler, Jan, Holla, Andrea, Hunziker, Juerg, Meisner‐Kober, Nicole, Schuler, Benjamin, Jeschke, Gunnar, Allain, Frederic H‐T

“…The accurate cleavage of pre‐micro(mi)RNAs by Dicer and mi/siRNA guide strand selection are important steps in forming the RNA‐induced silencing complex…”
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Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA by Theler, Dominik, Dominguez, Cyril, Blatter, Markus, Boudet, Julien, Allain, Frédéric H-T

“…N(6)A methylation is the most abundant RNA modification occurring within messenger RNA. Impairment of methylase or demethylase functions are associated with…”
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Structural basis for −10 promoter element melting by environmentally induced sigma factors by Campagne, Sébastien, Marsh, May E, Capitani, Guido, Vorholt, Julia A, Allain, Frédéric H-T

“…Bacteria use alternative sigma factors to direct transcription initiation from new sets of gene promoters in response to environmental stress. Complementary…”
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Structural basis of the non-coding RNA RsmZ acting as a protein sponge by Duss, Olivier, Michel, Erich, Yulikov, Maxim, Schubert, Mario, Jeschke, Gunnar, Allain, Frédéric H.-T.

“…MicroRNA and protein sequestration by non-coding RNAs (ncRNAs) has recently generated much interest. In the bacterial Csr/Rsm system, which is considered to be…”
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RNA‐PROTACs: Degraders of RNA‐Binding Proteins by Ghidini, Alice, Cléry, Antoine, Halloy, François, Allain, Frédéric H. T., Hall, Jonathan

“…Defects in the functions of RNA binding proteins (RBPs) are at the origin of many diseases; however, targeting RBPs with conventional drugs has proven…”
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RNA recognition by double-stranded RNA binding domains: a matter of shape and sequence by Masliah, Grégoire, Barraud, Pierre, Allain, Frédéric H. -T.

“…The double-stranded RNA binding domain (dsRBD) is a small protein domain of 65–70 amino acids adopting an αβββα fold, whose central property is to bind to…”
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SRSF1-Regulated Alternative Splicing in Breast Cancer by Anczuków, Olga, Akerman, Martin, Cléry, Antoine, Wu, Jie, Shen, Chen, Shirole, Nitin H., Raimer, Amanda, Sun, Shuying, Jensen, Mads A., Hua, Yimin, Allain, Frédéric H.-T., Krainer, Adrian R.

“…Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression promotes transformation of mammary cells. Using RNA-seq, we identified…”
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Stabilization of Branched Oligosaccharides: Lewisx Benefits from a Nonconventional C–H···O Hydrogen Bond by Zierke, Mirko, Smieško, Martin, Rabbani, Said, Aeschbacher, Thomas, Cutting, Brian, Allain, Frédéric H.-T., Schubert, Mario, Ernst, Beat

“…Although animal lectins usually show a high degree of specificity for glycan structures, their single-site binding affinities are typically weak, a drawback…”
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Structural basis of a small molecule targeting RNA for a specific splicing correction by Campagne, Sébastien, Boigner, Sarah, Rüdisser, Simon, Moursy, Ahmed, Gillioz, Laurent, Knörlein, Anna, Hall, Jonathan, Ratni, Hasane, Cléry, Antoine, Allain, Frédéric H.-T.

“…Splicing modifiers promoting SMN2 exon 7 inclusion have the potential to treat spinal muscular atrophy, the leading genetic cause of infantile death. These…”
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Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation by Afroz, Tariq, Hock, Eva-Maria, Ernst, Patrick, Foglieni, Chiara, Jambeau, Melanie, Gilhespy, Larissa A. B., Laferriere, Florent, Maniecka, Zuzanna, Plückthun, Andreas, Mittl, Peer, Paganetti, Paolo, Allain, Frédéric H. T., Polymenidou, Magdalini

“…TDP-43 is a primarily nuclear RNA-binding protein, whose abnormal phosphorylation and cytoplasmic aggregation characterizes affected neurons in patients with…”
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Gac/Rsm signal transduction pathway of γ-proteobacteria: from RNA recognition to regulation of social behaviour by Lapouge, Karine, Schubert, Mario, Allain, Frédéric H.-T, Haas, Dieter

“…In many γ-proteobacteria, the conserved GacS/GacA (BarA/UvrY) two-component system positively controls the expression of one to five genes specifying small…”
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High-Resolution Structural Analysis Shows How Tah1 Tethers Hsp90 to the R2TP Complex by Back, Régis, Dominguez, Cyril, Rothé, Benjamin, Bobo, Claude, Beaufils, Chrystel, Moréra, Solange, Meyer, Philippe, Charpentier, Bruno, Branlant, Christiane, Allain, Frédéric H.-T., Manival, Xavier

“…The ubiquitous Hsp90 chaperone participates in snoRNP and RNA polymerase assembly through interaction with the R2TP complex. This complex includes the proteins…”
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Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43 by Lukavsky, Peter J, Daujotyte, Dalia, Tollervey, James R, Ule, Jernej, Stuani, Cristiana, Buratti, Emanuele, Baralle, Francisco E, Damberger, Fred F, Allain, Frédéric H-T

“…TDP-43 regulates alternative splicing of the cystic fibrosis transmembrane regulator (CFTR) and is found in cytosolic granules associated with several…”
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