Protective effect of metformin on D-galactose-induced aging model in mice

Protective effect of metformin on D-galactose-induced aging model in mice

Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactos...

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Published in:Iranian journal of basic medical sciences Vol. 21; no. 1; pp. 19 - 25
Main Authors: Fatemi, Iman, Khaluoi, Amin, Kaeidi, Ayat, Shamsizadeh, Ali, Heydari, Sara, Allahtavakoli, Mohammad Aa
Format: Journal Article
Language:English
Published: Iran Mashhad University of Medical Sciences 01-01-2018
Subjects:
Aging
Antidiabetics
Brain-derived neurotrophic factor
D-galactose
Metformin
Mouse
Original
Oxidative stress
Rodents
Aging
Oxidative stress
D-galactose
Metformin
Mouse
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Summary:Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. Met (1 and 10 mg/kg/p.o.), was administrated daily in D-gal-received (500 mg/kg/p.o.) mice model of aging for six weeks. Anxiety-like behavior, cognitive function, and physical power were evaluated by the elevated plus-maze, novel object recognition task (NORT), and forced swimming capacity test, respectively. The brains were analyzed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF). Met decreased the anxiety-like behavior in D-gal-treated mice. Also, Met treated mice showed significantly improved learning and memory ability in NORT compared to the D-gal-treated mice. Furthermore, Met increased the physical power as well as the activity of SOD and BDNF level in D-gal-treated mice. Our results suggest that the use of Met can be an effective strategy for prevention and treatment of D-gal-induced aging in animal models. This effect seems to be mediated by attenuation of oxidative stress and enhancement of the neurotrophic factors.
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ISSN:2008-3866
2008-3874
DOI:10.22038/IJBMS.2017.24331.6071