Search Results - "Alkon, Daniel L."

Peripheral biomarkers of Alzheimer's disease by Khan, Tapan K, Alkon, Daniel L

“…Currently available diagnostic tests have moved the field closer to early diagnosis of Alzheimer's disease (AD); however, a definitive diagnosis is made only…”
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structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC by Hongpaisan, Jarin, Alkon, Daniel L

“…Using both scanning confocal and electron microscopic morphometric measurements, we analyzed single dendritic spines of CA1 pyramidal cells in the hippocampi…”
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Protein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture by Lim, Chol Seung, Alkon, Daniel L.

“…HuD protein is an RNA‐binding protein involved in post‐transcriptional regulation of gene expression for synaptogenesis, neuronal differentiation, and learning…”
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A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Assessing Safety, Tolerability, and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease by Farlow, Martin R, Thompson, Richard E, Wei, Lee-Jen, Tuchman, Alan J, Grenier, Elaine, Crockford, David, Wilke, Susanne, Benison, Jeffrey, Alkon, Daniel L

“…Bryostatin-activated PKC epsilon pre-clinically induces synaptogenesis, anti-apoptosis, anti-amyloid-β oligomers, and anti-hyperphosphorylated tau. To…”
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PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease by Alkon, Daniel L, Sun, Miao-Kun, Nelson, Thomas J

“…There is strong evidence that protein kinase C (PKC) isozyme signaling pathways are causally involved in associative memory storage. Other observations have…”
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Inhibition of coactivator-associated arginine methyltransferase 1 modulates dendritic arborization and spine maturation of cultured hippocampal neurons by Lim, Chol Seung, Alkon, Daniel L.

“…An improved understanding of the molecular mechanisms in synapse formation provides insight into both learning and memory and the etiology of neurodegenerative…”
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ApoE isoforms differentially regulates cleavage and secretion of BDNF by Sen, Abhik, Nelson, Thomas J, Alkon, Daniel L

“…Apolipoprotein E4 (ApoE4) is a major genetic risk factor for sporadic or late onset Alzheimer's disease (AD). Brain-derived neurotrophic factor (BDNF) is…”
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The ε-Isozyme of Protein Kinase C (PKCε) Is Impaired in ALS Motor Cortex and Its Pulse Activation by Bryostatin-1 Produces Long Term Survival in Degenerating SOD1-G93A Motor Neuron-like Cells by La Cognata, Valentina, D’Amico, Agata Grazia, Maugeri, Grazia, Morello, Giovanna, Guarnaccia, Maria, Magrì, Benedetta, Aronica, Eleonora, Alkon, Daniel L., D’Agata, Velia, Cavallaro, Sebastiano

“…Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and ultimately fatal neurodegenerative disease, characterized by a progressive depletion of upper…”
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Morphometric imaging biomarker identifies Alzheimer’s disease even among mixed dementia patients by Chirila, Florin V., Xu, Guang, Fontaine, Dan, Kern, Grant, Khan, Tapan K., Brandt, Jason, Konishi, Yoshihiro, Nebe-von-Caron, Gerhard, White, Charles L., Alkon, Daniel L.

“…A definitive diagnosis of Alzheimer’s disease (AD), even in the presence of co-morbid neuropathology (occurring in > 50% of AD cases), is a significant unmet…”
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PKC activation during training restores mushroom spine synapses and memory in the aged rat by Hongpaisan, Jarin, Xu, Changqing, Sen, Abhik, Nelson, Thomas J, Alkon, Daniel L

“…Abstract Protein kinase C (PKC) ε and α activation has been implicated in synaptogenesis. We used aged rats to test whether the PKCε/α activator bryostatin and…”
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Common mechanisms of Alzheimer's disease and ischemic stroke: the role of protein kinase C in the progression of age-related neurodegeneration by Lucke-Wold, Brandon P, Turner, Ryan C, Logsdon, Aric F, Simpkins, James W, Alkon, Daniel L, Smith, Kelly E, Chen, Yi-Wen, Tan, Zhenjun, Huber, Jason D, Rosen, Charles L

“…Ischemic stroke and Alzheimer's disease (AD), despite being distinct disease entities, share numerous pathophysiological mechanisms such as those mediated by…”
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Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice by Cogram, Patricia, Alkon, Daniel L., Crockford, David, Deacon, Robert M. J., Hurley, Michael J., Altimiras, Francisco, Sun, Miao-Kun, Tranfaglia, Michael

“…Fragile X syndrome (FXS), an X-chromosome linked intellectual disability, is the leading monogenetic cause of autism spectrum disorder (ASD), a…”
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Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair by Nelson, Thomas. J., Sun, Miao-Kun, Hongpaisan, Jarin, Alkon, Daniel L.

“…Protein kinase C (PKC) is involved in synaptic remodeling, induction of protein synthesis, and many other processes important in learning and memory…”
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Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brains by Sun, Miao-Kun, Hongpaisan, Jarin, Nelson, Thomas J, Alkon, Daniel L

“…Global cerebral ischemia/hypoxia, as can occur during human stroke, damages brain neural networks and synaptic functions. The recently demonstrated protein…”
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Insulin and the insulin receptor in experimental models of learning and memory by Zhao, Wei-Qin, Chen, Hui, Quon, Michael J., Alkon, Daniel L.

“…Insulin is best known for its action on peripheral insulin target tissues such as the adipocyte, muscle and liver to regulate glucose homeostasis. In the…”
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Postischemic PKC Activation Rescues Retrograde and Anterograde Long-Term Memory by Sun, Miao-Kun, Hongpaisan, Jarin, Alkon, Daniel L., Witkop, Bernhard

“…Therapeutics for cerebral ischemia/hypoxia, which often results in ischemie stroke in humans, are a global unmet medical need. Here, we report that…”
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Therapeutic Effects of PKC Activators in Alzheimer's Disease Transgenic Mice by Etcheberrigaray, René, Tan, Mathew, Dewachter, Ilse, Kuipéri, Cuno, Van der Auwera, Ingrid, Wera, Stefaan, Qiao, Lixin, Bank, Barry, Nelson, Thomas J., Kozikowski, Alan P., Van Leuven, Fred, Alkon, Daniel L., Witkop, Bernhard

“…Alzheimer's disease (AD) characteristically presents with early memory loss. Regulation of K+channels, calcium homeostasis, and protein kinase C (PKC)…”
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Role of insulin and insulin receptor in learning and memory by Zhao, Wei-Qin, Alkon, Daniel L

“…As one of the most extensively studied protein hormones, insulin and its receptor have been known to play key roles in a variety of important biological…”
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Insulin Receptor Signaling in Long-Term Memory Consolidation Following Spatial Learning by Dou, Jing-Tao, Chen, Min, Dufour, Franck, Alkon, Daniel L, Zhao, Wei-Qin

“…Evidence has shown that the insulin and insulin receptor (IR) play a role in cognitive function. However, the detailed mechanisms underlying insulin's action…”
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Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer's disease peripheral biomarker by Khan, Tapan Kumar, Alkon, Daniel L

“…Abstract Treatment of Alzheimer's disease (AD) and the discovery of promising drug candidates depend on early diagnosis. Few currently available diagnostic…”
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