Search Results - "Alkon, D"

Neuroprotective versus tumorigenic protein kinase C activators by Nelson, T.J., Alkon, D.L.

“…Protein kinase C (PKC) activators possess potent neurotrophic and neuroprotective activity, thus indicating potential applications in treating…”
Get full text

CNS stem and progenitor cell differentiation into functional neuronal circuits in three-dimensional collagen gels by Ma, W., Fitzgerald, W., Liu, Q.-Y., O'Shaughnessy, T.J., Maric, D., Lin, H.J., Alkon, D.L., Barker, J.L.

“…The mammalian central nervous system (CNS) has little capacity for self-repair after injury, and neurons are not capable of proliferating. Therefore, neural…”
Get full text

PKC activators enhance GABAergic neurotransmission and paired-pulse facilitation in hippocampal CA1 pyramidal neurons by Xu, C, Liu, Q.-Y, Alkon, D.L

“…Highlights • Bryostatin enhanced Brown Norway rat spatial learning and memory. • Bryostatin significantly increased the frequency and amplitude of sIPSC. •…”
Get full text

PKC activator therapeutic for mild traumatic brain injury in mice by Zohar, Ofer, Lavy, Rotem, Zi, Xiaomei, Nelson, Thomas J, Hongpaisan, Jarin, Pick, Chaim G, Alkon, D.L

“…Abstract Traumatic brain injury (TBI) is a frequent consequence of vehicle, sport and war related injuries. More than 90% of TBI patients suffer mild injury…”
Get full text

Induced depressive behavior impairs learning and memory in rats by Sun, M.-K., Alkon, D.L.

“…While it is generally accepted that cognitive processes such as learning and memory are affected by emotion, the impact of depression on learning and memory…”
Get full text

Role of insulin and insulin receptor in learning and memory by Zhao, Wei-Qin, Alkon, Daniel L

“…As one of the most extensively studied protein hormones, insulin and its receptor have been known to play key roles in a variety of important biological…”
Get full text

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease by Gasparini, L, Racchi, M, Binetti, G, Trabucchi, M, Solerte, S B, Alkon, D, Etcheberrigaray, R, Gibson, G, Blass, J, Paoletti, R, Govoni, S

“…Alterations in amyloid precursor protein (APP) metabolism, calcium regulation, oxidative metabolism, and transduction systems have been implicated in…”
Get full text

Age-dependent differential expression of BACE splice variants in brain regions of tg2576 mice by Zohar, O., Pick, C.G., Cavallaro, S., Chapman, J., Katzav, A., Milman, A., Alkon, D.L.

“…Plaques found in the brains of patients suffering from Alzheimer's disease (AD) mainly consist of β-amyloid (Aβ), which is produced by sequential cleaving of…”
Get full text

Time domains of neuronal Ca2+ signaling and associative memory : steps through a calexcitin, ryanodine receptor, K+ channel cascade by ALKON, D. L, NELSON, T. J, WEIQIN ZHAO, CAVALLARO, S

“…Synaptic changes that underlie associative learning and memory begin with temporally related activity of two or more independent synaptic inputs to common…”
Get full text

Bryostatin Enhancement of Memory in Hermissenda by Kuzirian, A. M., Epstein, H. T., C. J. Gagliardi, Nelson, T. J., M. Sakakibara, Taylor, C., A. B. Scioletti, Alkon, D. L.

“…Bryostatin, a potent agonist of protein kinase C (PKC), when administered to Hermissenda was found to affect acquisition of an associative learning paradigm…”
Get full text

Internal Ca2+Mobilization is Altered in Fibroblasts from Patients with Alzheimer Disease by Ito, Etsuro, Oka, Kotaro, Etcheberrigaray, Rene, Nelson, Thomas J., McPhie, Donna L., Tofel-Grehl, Beth, Gibson, Gary E., Alkon, Daniel L.

“…The recent demonstration of K+channel dysfunction in fibroblasts from Alzheimer disease (AD) patients and past observations of Ca2+-mediated K+channel…”
Get full text

Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats by Zhao, W, Chen, H, Xu, H, Moore, E, Meiri, N, Quon, M J, Alkon, D L

“…Evidence accumulated from clinical and basic research has indirectly implicated the insulin receptor (IR) in brain cognitive functions, including learning and…”
Get full text

Memory-Specific Temporal Profiles of Gene Expression in the Hippocampus by Cavallaro, Sebastiano, D'Agata, Velia, Manickam, Pachiappan, Dufour, Franck, Alkon, Daniel L.

“…Many experiments in the past have demonstrated the requirement of de novo gene expression during the long-term retention of learning and memory. Although…”
Get full text

Increase of the RNA-Binding Protein HuD and Posttranscriptional Up-Regulation of the GAP-43 Gene during Spatial Memory by Pascale, Alessia, Gusev, Pavel A., Amadio, Marialaura, Dottorini, Tania, Govoni, Stefano, Alkon, Daniel L., Quattrone, Alessandro

“…Neuronal ELAV-like proteins (HuB, HuC, and HuD) are highly conserved RNA-binding proteins able to selectively associate with the 3′ UTR of a subset of target…”
Get full text

Carbonic anhydrase gating of attention: memory therapy and enhancement by Sun, Miao-Kun, Alkon, Daniel L

“…Enhancement of memory acquisition and recall represents an important pharmacological goal in the treatment of cognitive disorders. In addition to its…”
Get full text

Insulin and cholesterol pathways in neuronal function, memory and neurodegeneration by Nelson, T J, Alkon, D L

“…Insulin and cholesterol play important roles in basic metabolic processes in peripheral tissues. Both insulin and cholesterol can also act as signalling…”
Get more information

Accelerating the convergence of the back-propagation method by VOGL, T. P, MANGIS, J. K, RIGLER, A. K, ZINK, W. T, ALKON, D. L

“…The utility of the back-propagation method in establishing suitable weights in a distributed adaptive network has been demonstrated repeatedly. Unfortunately,…”
Get full text

Prevention of β‐Amyloid Neurotoxicity by Blockade of the Ubiquitin—Proteasome Proteolytic Pathway by Favit, Antonella, Grimaldi, Maurizio, Alkon, Daniel L.

“…: In many neurodegenerative disorders, such as Alzheimer's disease, inclusions containing ubiquitinated proteins have been found in the brain, suggesting a…”
Get full text

Dual effects of bryostatin-1 on spatial memory and depression by Sun, Miao-Kun, Alkon, Daniel L.

“…Dementia and depression are clinical symptoms commonly associated in patients. Emerging evidence suggests that the two diseases share many profiles in their…”
Get full text

Management of complex groin wounds: preferred use of the rectus femoris muscle flap by Alkon, Joseph D, Smith, Andrew, Losee, Joseph E, Illig, Karl A, Green, Richard M, Serletti, Joseph M

“…This study reviews our experience with the rectus femoris muscle flap for complex groin wound reconstruction. Over the past 5 years, the rectus femoris has…”
Get full text