Radiation-modifying abilities of Nigella sativa and Thymoquinone on radiation-induced nitrosative stress in the brain tissue

Radiation-modifying abilities of Nigella sativa and Thymoquinone on radiation-induced nitrosative stress in the brain tissue

To investigate Nigella sativa oil (NSO) and Thymoquinone (TQ) for their antioxidant effects on the brain tissue of rats exposed to ionizing radiation. Fifty-four male albino Wistar rats, divided into six groups, were designed as group I (normal control group) did not receive NSO, TQ or irradiation;...

Full description

Saved in:
Bibliographic Details
Published in:Phytomedicine (Stuttgart) Vol. 21; no. 5; pp. 740 - 744
Main Authors: Ahlatci, Adem, Kuzhan, Abdurahman, Taysi, Seyithan, Demirtas, Omer Can, Alkis, Hilal Eryigit, Tarakcioglu, Mehmet, Demirci, Ali, Caglayan, Derya, Saricicek, Edibe, Cinar, Kadir
Format: Journal Article
Language:English
Published: Germany Elsevier GmbH 15-04-2014
Urban & Fischer Verlag
Subjects:
Animals
Antioxidants
Benzoquinones - pharmacology
Benzoquinones - therapeutic use
Biomarkers - metabolism
Brain
Brain - metabolism
Brain damage
Brain Injuries - chemically induced
Brain Injuries - metabolism
Brain Injuries - prevention & control
Care and treatment
Drug Evaluation, Preclinical
Health aspects
Ionizing radiation
Male
Medical research
Medicinal plants
Medicine, Experimental
Nigella sativa
Nitric oxide
Nitrosative stress
Phytotherapy
Plant Oils - pharmacology
Plant Oils - therapeutic use
Radiation Injuries, Experimental - chemically induced
Radiation Injuries, Experimental - metabolism
Radiation Injuries, Experimental - prevention & control
Random Allocation
Rats, Wistar
Reactive Nitrogen Species - adverse effects
Thymoquinone
Brain
Ionizing radiation
Nigella sativa
Nitrosative stress
Nitric oxide
Thymoquinone
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate Nigella sativa oil (NSO) and Thymoquinone (TQ) for their antioxidant effects on the brain tissue of rats exposed to ionizing radiation. Fifty-four male albino Wistar rats, divided into six groups, were designed as group I (normal control group) did not receive NSO, TQ or irradiation; group II (control group of TQ) received dimethyl sulfoxide and sham irradiation; group III (control group of NSO) received saline and sham irradiation; group IV (irradiation plus NSO group) received both 5 Gray of gamma irradiation to total cranium and NSO; group V (irradiation plus TQ group) received both irradiation and TQ; group VI (irradiation alone group) received irradiation plus saline. Alterations in nitric oxide (NO) and peroxynitrite (ONOO−) levels, and nitric oxide synthase (NOS) enzyme activity were measured by biochemical methods in homogenized brain tissue of rats. Levels of NO and ONOO−, and enzyme activity of NOS in brain tissue of the rats treated with NSO or TQ were found to be lower than in received IR alone (p<0.002) Nigella sativa oil (NSO) and its active component, TQ, clearly protect brain tissue from radiation-induced nitrosative stress.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2013.10.023