“Hot Cord” Sign on 18F-FDG PET/CT in a Patient With Acute Myelitis Due to Neuromyelitis Optica Spectrum Disorder

ABSTRACTA 44-year-old woman presented with prolonged low-grade fever, bilateral upper limb weakness, and hyperesthesia. MRI showed hyperintense T2 signal and enhancement of the cervicothoracic spinal cord. F-FDG PET/CT was requested to investigate pyrexia of unknown origin. It demonstrated diffusely...

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Bibliographic Details
Published in:	Clinical nuclear medicine Vol. 46; no. 1; pp. 74 - 75
Main Authors:	Alkhaja, Maryam Ahmed, Cheng, Lenith Tai Jit, Loi, Hoi Yin, Sinha, Arvind Kumar
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins 01-01-2021 Copyright Wolters Kluwer Health, Inc. All rights reserved
Subjects:	Acute Disease Adult Aquaporin 4 - immunology Autoantibodies - blood Autoantibodies - immunology Female Fluorodeoxyglucose F18 Humans Immunoglobulin G - blood Immunoglobulin G - immunology Myelitis - diagnostic imaging Myelitis - etiology Myelitis - immunology Neuromyelitis Optica - complications Positron Emission Tomography Computed Tomography
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Summary:	ABSTRACTA 44-year-old woman presented with prolonged low-grade fever, bilateral upper limb weakness, and hyperesthesia. MRI showed hyperintense T2 signal and enhancement of the cervicothoracic spinal cord. F-FDG PET/CT was requested to investigate pyrexia of unknown origin. It demonstrated diffusely increased FDG uptake along the entire spinal cord, suggestive of extensive acute myelitis. Initial blood work was positive for antinuclear antibodies and anti-Ro/SSA antibodies. Cerebrospinal fluid analysis revealed lymphocytosis and detected the presence of neuromyelitis optica aquaporin-4–immunoglobulin G antibodies, fulfilling the criteria for diagnosis of neuromyelitis optica spectrum disorder.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0363-9762 1536-0229
DOI:	10.1097/RLU.0000000000003367