Comparison of the efficacy of Tacrolimus 0.1% ointment and Tacrolimus 0.1% plus topical pseudocatalase/superoxide dismutase gel in children with limited vitiligo: a randomized controlled trial

Comparison of the efficacy of Tacrolimus 0.1% ointment and Tacrolimus 0.1% plus topical pseudocatalase/superoxide dismutase gel in children with limited vitiligo: a randomized controlled trial

The pathogenesis of vitiligo is complex and multifactorial, accumulating evidence of increased oxidative stress and reduction in catalase levels in vitiligo patients has been shown, hence, pseudocatalase/superoxide dismutase (PSD) gel has been used as treatment option for vitiligo. To assesses the s...

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Bibliographic Details
Published in:The Journal of dermatological treatment Vol. 33; no. 1; pp. 146 - 149
Main Authors: Alshiyab, Diala M., Al-qarqaz, Firas A., Muhaidat, Jihan M., Alkhader, Yousef S., Al-sheyab, Ruba F., Jafaar, Sala I.
Format: Journal Article
Language:English
Published: England Taylor & Francis 02-01-2022
Subjects:
Adolescent
Catalase
Child
Child, Preschool
Humans
Immunosuppressive Agents - therapeutic use
Ointments
pseudocatalase/superoxide dismutase (PSD)
Superoxide Dismutase
Tacrolimus - therapeutic use
Tacrolimus 0.1
Treatment Outcome
Vitiligo
Vitiligo - drug therapy
pseudocatalase/superoxide dismutase (PSD)
Vitiligo
Tacrolimus 0.1
catalase
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Summary:The pathogenesis of vitiligo is complex and multifactorial, accumulating evidence of increased oxidative stress and reduction in catalase levels in vitiligo patients has been shown, hence, pseudocatalase/superoxide dismutase (PSD) gel has been used as treatment option for vitiligo. To assesses the synergic effect of PSD when combines with Tacrolimus 0.1% ointment versus Tacrolimus 0.1% alone. A randomized controlled trial that included 49 children with vitiligo with limited area (10% or less). Patients were randomized into two groups: Group 1 (24 patients) were treated only with Tacrolimus 0.1% ointment whereas Group 2 (25 patients) were treated with Tacrolimus 0.1% ointment plus PSD. Degree of repigmentation compared to baseline was assessed at 3, 6, and 9 months. The median age was 10.05 years (range 2-18). The percentages of pigmentation on 3, 6, and 9 months for Group 1 were 23.9%, 40.4%, and 60%, respectively and for Group 2 were 23.2%, 40.7%, and 62.4%, respectively. There was no significant difference according to repigmentation percentages between the two groups (p > .86, p > .97, and p > .78, respectively). The results showed that the addition of PSD to Tacrolimus ointment in children with limited vitiligo was not associated with any therapeutic benefit.
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content type line 23
ISSN:0954-6634
1471-1753
DOI:10.1080/09546634.2020.1729952