Search Results - "Alkema, Manon"

Quantifying Reductions in Plasmodium falciparum Infectivity to Mosquitos: A Sample Size Calculator to Inform Clinical Trials on Transmission-Reducing Interventions by Ramjith, Jordache, Alkema, Manon, Bradley, John, Dicko, Alassane, Drakeley, Chris, Stone, Will, Bousema, Teun

“…Malaria transmission depends on the presence of mature transmission stages (gametocytes) that may render blood-feeding mosquitos infectious…”
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The effect of anticoagulants in blood collection tubes on Plasmodium falciparum transmission in direct membrane feeding assays by Graumans, Wouter, Lanke, Kjerstin, van Gemert, Geert-Jan, Alkema, Manon, van de Vegte-Bolmer, Marga, Bousema, Teun, Collins, Katharine A

“…Abstract Background Direct membrane feeding assays assess the transmission potential of malaria-infected individuals using whole blood collected in…”
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Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment by Abdi, Abdirahman I, Achcar, Fiona, Sollelis, Lauriane, Silva-Filho, João Luiz, Mwikali, Kioko, Muthui, Michelle, Mwangi, Shaban, Kimingi, Hannah W, Orindi, Benedict, Andisi Kivisi, Cheryl, Alkema, Manon, Chandrasekar, Amrita, Bull, Peter C, Bejon, Philip, Modrzynska, Katarzyna, Bousema, Teun, Marti, Matthias

“…The malaria parasite life cycle includes asexual replication in human blood, with a proportion of parasites differentiating to gametocytes required for…”
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Whole sporozoite immunization with Plasmodium falciparum strain NF135 in a randomized trial by van der Boor, Saskia C, Alkema, Manon, van Gemert, Geert-Jan, Teelen, Karina, van de Vegte-Bolmer, Marga, Walk, Jona, van Crevel, Reinout, de Mast, Quirijn, Ockenhouse, Christian F, Sauerwein, Robert W, McCall, Matthew B B

“…Whole sporozoite immunization under chemoprophylaxis (CPS regime) induces long-lasting sterile homologous protection in the controlled human malaria infection…”
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The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections by de Jong, Roos M, Alkema, Manon, Oulton, Tate, Dumont, Elin, Teelen, Karina, Nakajima, Rie, de Assis, Rafael Ramiro, Press, Kathleen W Dantzler, Ngotho, Priscilla, Tetteh, Kevin K A, Felgner, Phil, Marti, Matthias, Collins, Katharine A, Drakeley, Chris, Bousema, Teun, Stone, Will J R

“…Individuals infected with develop antibody responses to intra-erythrocytic gametocyte proteins and exported gametocyte proteins present on the surface of…”
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Controlled human malaria infections by mosquito bites induce more severe clinical symptoms than asexual blood-stage challenge infections by Alkema, Manon, Yap, X. Zen, de Jong, Gerdie M., Reuling, Isaie J., de Mast, Quirijn, van Crevel, Reinout, Ockenhouse, Christian F., Collins, Katharine A., Bousema, Teun, McCall, Matthew B.B., Sauerwein, Robert W.

“…Fever and inflammation are a hallmark of clinical Plasmodium falciparum (Pf) malaria induced by circulating asexual parasites. Although clinical manifestations…”
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A Randomized Clinical Trial to Compare Plasmodium falciparum Gametocytemia and Infectivity After Blood-Stage or Mosquito Bite–Induced Controlled Malaria Infection by Alkema, Manon, Reuling, Isaie J, de Jong, Gerdie M, Lanke, Kjerstin, Coffeng, Luc E, van Gemert, Geert-Jan, van de Vegte-Bolmer, Marga, de Mast, Quirijn, van Crevel, Reinout, Ivinson, Karen, Ockenhouse, Christian F, McCarthy, James S, Sauerwein, Robert, Collins, Katharine A, Bousema, Teun

“…Abstract Background For malaria elimination efforts, it is important to better understand parasite transmission to mosquitoes and develop models for…”
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Corrigendum to: A Randomized Clinical Trial to Compare Plasmodium falciparum Gametocytemia and Infectivity After Blood-Stage or Mosquito Bite–Induced Controlled Malaria Infection by Alkema, Manon, Reuling, Isaie J, de Jong, Gerdie M, Lanke, Kjerstin, Coffeng, Luc E, van Gemert, Geert-Jan, van de Vegte-Bolmer, Marga, de Mast, Quirijn, van Crevel, Reinout, Ivinson, Karen, Ockenhouse, Christian F, McCarthy, James S, Sauerwein, Robert, Collins, Katharine A, Bousema, Teun

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Abstract A65: Unraveling the rhabdomyosarcoma genome using mouse mosaicism by McKinnon, Timothy, Venier, Rosemarie, Alkema, Manon, Kabaroff, Leah, Khan, Javed, Dickson, Brendan, Gladdy, Rebecca

“…Introduction: Rhabdomyosarcoma (RMS) represents the most common pediatric soft tissue sarcoma. Despite advances in multimodality therapy, outcomes in…”
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Abstract B15: Optimization of an oncogenomics-based in vivo screen to validate candidate sarcoma genes by McKinnon, Timothy, Venier, Rosemarie, Alkema, Manon, Kabaroff, Leah, Dickson, Brendan, Gladdy, Rebecca

“…Animal models are a powerful means to dissect the molecular events regulating carcinogenesis and also serve as pre-clinical models for drug development…”
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Loss Of Tumor Suppressor BTG1 Enhances ATF4 Function and Promotes Cell Survival by van der Meer, Laurens T., Yuniati, Laurensia, Tijchon, Esther J.H., van Emst, Liesbeth, Alkema, Manon, Rodenbach, Caroline, Scheijen, Blanca, Hoogerbrugge, Peter M., van Leeuwen, Frank N.

“…We and others have shown that the B cell Translocation Gene 1 (BTG1) locus is affected by genomic deletions in 9% of pediatric acute lymphoblastic leukemia…”
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Kras activation in p53-deficient myoblasts results in high-grade sarcoma formation with impaired myogenic differentiation by McKinnon, Timothy, Venier, Rosemarie, Dickson, Brendan C, Kabaroff, Leah, Alkema, Manon, Chen, Li, Shern, Jack F, Yohe, Marielle E, Khan, Javed, Gladdy, Rebecca A

“…While genomic studies have improved our ability to classify sarcomas, the molecular mechanisms involved in the formation and progression of many sarcoma…”
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